Arrestin

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  Subject Areas on Research

  • A role for myocilin in receptor-mediated endocytosis. 
  • Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. 
  • An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. 
  • Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. 
  • Beyond desensitization: physiological relevance of arrestin-dependent signaling. 
  • Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. 
  • Desensitization of G protein-coupled receptors. 
  • Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. 
  • Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1. 
  • Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). 
  • Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. 
  • G Protein and β-arrestin signaling bias at the ghrelin receptor. 
  • G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors. 
  • G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins. 
  • G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. 
  • GPCR signaling: conformational activation of arrestins. 
  • Histologic development of the human fovea from midgestation to maturity. 
  • Identification of a novel locus on 2q for autosomal dominant high-grade myopia. 
  • Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. 
  • Novel adamantyl cannabinoids as CB1 receptor probes. 
  • Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. 
  • Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation. 
  • Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. 
  • Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. 
  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. 
  • Structure and function of the visual arrestin oligomer. 
  • The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors. 
  • beta-Arrestin: a protein that regulates beta-adrenergic receptor function. 
  • mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse.