Integrases

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  Subject Areas on Research

  • A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells. 
  • A mitotic recombination system for mouse chromosome 17. 
  • A mosaic analysis system with Cre or Tomato expression in the mouse. 
  • A mouse model of adult-onset anaemia due to erythropoietin deficiency. 
  • A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme. 
  • A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. 
  • Ager-CreERT2: A New Genetic Tool for Studying Lung Alveolar Development, Homeostasis, and Repair. 
  • An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. 
  • Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. 
  • Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Cre-dependent adeno-associated virus preparation and delivery for labeling neurons in the mouse brain. 
  • Cre/LoxP-HBV plasmids generating recombinant covalently closed circular DNA genome upon transfection. 
  • Development and use of SIV-based Integrase defective lentiviral vector for immunization. 
  • Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis. 
  • Factors Associated With Systemic Immune Activation Indices in a Global Primary Cardiovascular Disease Prevention Cohort of People With Human Immunodeficiency Virus on Antiretroviral Therapy. 
  • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. 
  • Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing. 
  • Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. 
  • Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. 
  • Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma. 
  • Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Going green in Cryptococcus neoformans: the recycling of a selectable drug marker. 
  • High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing. 
  • High-resolution labeling and functional manipulation of specific neuron types in mouse brain by Cre-activated viral gene expression. 
  • Hypothalamic CaMKK2 contributes to the regulation of energy balance. 
  • Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques. 
  • Improved Survival After Liver Transplantation for Patients With Human Immunodeficiency Virus (HIV) and HIV/Hepatitis C Virus Coinfection in the Integrase Strand Transfer Inhibitor and Direct-Acting Antiviral Eras. 
  • Injury promotes sarcoma development in a genetically and temporally restricted manner. 
  • Integrase-defective lentiviral-vector-based vaccine: a new vector for induction of T cell immunity. 
  • Integration specificities of two lambdoid phages (21 and e14) that insert at the same attB site. 
  • Intersectional Cre driver lines generated using split-intein mediated split-Cre reconstitution. 
  • Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives. 
  • Long-term survival of influenza virus infected club cells drives immunopathology. 
  • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. 
  • Methods to generate genetically engineered mouse models of soft tissue sarcoma. 
  • Multiple gene deletion in Cryptococcus neoformans using the Cre-lox system. 
  • Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component. 
  • Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice. 
  • National Landscape of Human Immunodeficiency Virus-Positive Deceased Organ Donors in the United States. 
  • Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion. 
  • Novel integrase-defective lentiviral episomal vectors for gene transfer. 
  • Oligodendroglial and pan-neural crest expression of Cre recombinase directed by Sox10 enhancer. 
  • Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. 
  • Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector. 
  • Optimized regimen for expression of heat-inducible Cre in mice. 
  • Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. 
  • Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. 
  • Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. 
  • Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line. 
  • Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. 
  • Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. 
  • Retina- and ventral forebrain-specific Cre recombinase activity in transgenic mice. 
  • Retroviral DNA integration: viral and cellular determinants of target-site selection. 
  • Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. 
  • Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet. 
  • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. 
  • Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. 
  • Successful immunization with a single injection of non-integrating lentiviral vector. 
  • Supratrigeminal Bilaterally Projecting Neurons Maintain Basal Tone and Enable Bilateral Phasic Activation of Jaw-Closing Muscles. 
  • Synthesis of programmable integrases. 
  • TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function. 
  • Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene. 
  • Targeting cells with single vectors using multiple-feature Boolean logic. 
  • Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination. 
  • Temporal control of gene deletion in sensory ganglia using a tamoxifen-inducible Advillin-Cre-ERT2 recombinase mouse. 
  • Tissue-specific inactivation of murine M6P/IGF2R. 
  • Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. 
  • Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells. 
  • Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments. 
  • VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. 
  • p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. 
  • p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. 
  • p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. 
  • rAAV-compatible MiniPromoters for restricted expression in the brain and eye. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology