Insect Proteins

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  Subject Areas on Research

  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A proteomic analysis of human cilia: identification of novel components. 
  • A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. 
  • Activated armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila. 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. 
  • Analysis of the action of lidocaine on insect sodium channels. 
  • Ant Olfaction: Smells Like an Insect, Develops Like a Mammal. 
  • Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 
  • Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests. 
  • Cell adhesion molecule L1 in folded (horseshoe) and extended conformations. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Chaperones rescue luciferase folding by separating its domains. 
  • Charge substitutions at the voltage-sensing module of domain III enhance actions of site-3 and site-4 toxins on an insect sodium channel. 
  • Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti. 
  • Concentration-Independent Multivalent Targeting of Cancer Cells by Genetically Encoded Core-Crosslinked Elastin/Resilin-like Polypeptide Micelles. 
  • Contrasting Roles of Transcription Factors Spineless and EcR in the Highly Dynamic Chromatin Landscape of Butterfly Wing Metamorphosis. 
  • Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins. 
  • Correlating notch signaling with thymocyte maturation. 
  • Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control. 
  • Developmental mechanisms of body size and wing-body scaling in insects. 
  • Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides. 
  • Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin 
  • Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. 
  • Drosophila Tcf and Groucho interact to repress Wingless signalling activity. 
  • Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. 
  • Evolution of the gene network underlying wing polyphenism in ants. 
  • Fine scale spatial investigation of multiple insecticide resistance and underlying target-site and metabolic mechanisms in Anopheles gambiae in central Côte d'Ivoire. 
  • Focus on butterfly eyespot development. 
  • Genome-based identification of spliceosomal proteins in the silk moth Bombyx mori. 
  • Heat-shock-specific phosphorylation and transcriptional activity of RNA polymerase II. 
  • IAP proteins: blocking the road to death's door. 
  • Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. 
  • Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. 
  • Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel. 
  • Improving the odorant sensitivity of olfactory receptor-expressing yeast with accessory proteins. 
  • Insight into the Mode of Action of Haedoxan A from Phryma leptostachya. 
  • Mechanism of threshold size assessment: Metamorphosis is triggered by the TGF-beta/Activin ligand Myoglianin. 
  • Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides. 
  • Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions. 
  • Molecular and functional characterization of a novel sodium channel TipE-like auxiliary subunit from the American cockroach Periplaneta americana. 
  • Molecular basis of selective resistance of the bumblebee BiNa_v 1 sodium channel to tau-fluvalinate. 
  • Molecular characterization of a sodium channel gene from the Silkworm Bombyx mori. 
  • Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato. 
  • Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics. 
  • Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance. 
  • Negative regulation of Armadillo, a Wingless effector in Drosophila. 
  • Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Proper function of the Drosophila trp gene product during pupal development is important for normal visual transduction in the adult. 
  • Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes. 
  • Reaper is regulated by IAP-mediated ubiquitination. 
  • Requirement for the vasa RNA helicase in gurken mRNA localization. 
  • Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel. 
  • Scythe: a novel reaper-binding apoptotic regulator. 
  • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Sodium channel activation underlies transfluthrin repellency in Aedes aegypti. 
  • Stem cells: A tale of two kingdoms. 
  • Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). 
  • Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. 
  • The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. 
  • The IAP proteins: caspase inhibitors and beyond. 
  • The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides. 
  • The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. 
  • The genetic basis of a plant-insect coevolutionary key innovation. 
  • The insecticidal potential of scorpion beta-toxins. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids. 
  • Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. 
  • Ultrabithorax function in butterfly wings and the evolution of insect wing patterns. 
  • Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila. 
  • Visualization of replication initiation and elongation in Drosophila. 
  • Wnt signalling shows its versatility. 
  • mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. 
  • optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology