Bone Morphogenetic Proteins

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  Subject Areas on Research

  • A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 
  • A P(E)RM(I)T for BMP signaling. 
  • A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion. 
  • A novel mutation in the gene encoding noggin is not causative in human neural tube defects. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. 
  • An essential role of Bmp4 in the atrioventricular septation of the mouse heart. 
  • Are recombinant human bone morphogenetic protein-7 and tobramycin compatible? An experiment in rats. 
  • Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. 
  • BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. 
  • BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. 
  • BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. 
  • BMP ligands act redundantly to pattern the dorsal telencephalic midline. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 
  • BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 
  • BMP signaling in the development of the mouse esophagus and forestomach. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Bmp signaling is required for intestinal growth and morphogenesis. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bmps: multifunctional regulators of mammalian embryonic development. 
  • Bone Graft Options in Upper-Extremity Surgery. 
  • Bone Morphogenetic Proteins Are Expressed by Both Bone-Forming and Non-Bone-Forming Lesions. 
  • Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation. 
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. 
  • Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. 
  • Bone morphogenetic protein induces bone in the squirrel monkey, but bone matrix does not. 
  • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. 
  • Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. 
  • Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland. 
  • Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. 
  • Bone morphogenetic proteins and cancer: review of the literature. 
  • Bone morphogenetic proteins and degenerative disk disease. 
  • Bone morphogenetic proteins in development. 
  • Bone morphogenetic proteins in total hip arthroplasty, osteonecrosis and trauma surgery. 
  • Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2. 
  • Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor. 
  • Bone morphogenetic proteins: multifunctional regulators of vertebrate development. 
  • Cancer after spinal fusion: the role of bone morphogenetic protein. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. 
  • Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene. 
  • Chordin and noggin promote organizing centers of forebrain development in the mouse. 
  • Chordin is required for neural but not axial development in sea urchin embryos. 
  • Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development. 
  • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. 
  • DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Degenerative lumbar scoliosis. 
  • Developmental biology: decisions, decisions! 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Does bone morphogenetic protein increase the incidence of perioperative complications in spinal fusion? A comparison of 55,862 cases of spinal fusion with and without bone morphogenetic protein. 
  • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. 
  • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. 
  • Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. 
  • Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. 
  • Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Evidence supporting the use of bone morphogenetic proteins for spinal fusion surgery. 
  • Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. 
  • Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. 
  • Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. 
  • Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Fgf8 is required for anterior heart field development. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. 
  • Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. 
  • Growth factors in development: the role of TGF-beta related polypeptide signalling molecules in embryogenesis. 
  • Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. 
  • Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism. 
  • High expression of BMP pathway genes distinguishes a subset of atypical teratoid/rhabdoid tumors associated with shorter survival. 
  • Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. 
  • Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment. 
  • Immediate Effects of Use of Recombinant Bone Morphogenetic Protein in Children Having Spinal Fusion and Refusion Procedures in United States. 
  • In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts. 
  • Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle. 
  • Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture. 
  • Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. 
  • Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Left-right asymmetry in the sea urchin embryo: BMP and the asymmetrical origins of the adult. 
  • Long-Segment Fusion for Adult Spinal Deformity Correction Using Low-Dose Recombinant Human Bone Morphogenetic Protein-2: A Retrospective Review of Fusion Rates. 
  • Long-term healing of bone using recombinant human bone morphogenetic protein 2. 
  • LvTbx2/3, a T-box Family Transcription Factor Involved in Formation of the Oral/Aboral Axis of the Sea Urchin Embryo 
  • Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth. 
  • Mice lacking Bmp6 function. 
  • Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. 
  • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. 
  • Molecular morphogens. Upside-down ideas vindicated. 
  • Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. 
  • Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton. 
  • Multiple-day drainage when using bone morphogenic protein for long-segment thoracolumbar fusions is associated with low rates of wound complications. 
  • Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling. 
  • Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. 
  • New treatment approaches for osteonecrosis of the femoral head: an overview. 
  • Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan. 
  • Nonvascularized bone grafting defers joint arthroplasty in hip osteonecrosis. 
  • Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. 
  • Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A). 
  • Outcomes of bone morphogenetic protein-2 in mature adults: posterolateral non-instrument-assisted lumbar decompression and fusion. 
  • Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. 
  • Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. 
  • Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia. 
  • Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer. 
  • Regeneration of fat cells from myofibroblasts during wound healing. 
  • Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. 
  • Roles of bone morphogenetic protein signaling and its antagonism in holoprosencephaly. 
  • Roles of organizer factors and BMP antagonism in mammalian forebrain establishment. 
  • Scaffold-based rhBMP-2 therapy in a rat alveolar defect model: implications for human gingivoperiosteoplasty. 
  • Signaling cross-talk between TGF-beta/BMP and other pathways. 
  • Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. 
  • Structure and sequence of the mouse Bmp6 gene. 
  • Symptomatic calcified perineural cyst after use of bone morphogenetic protein in transforaminal lumbar interbody fusion: a case report. 
  • TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. 
  • TGF-beta related genes in development. 
  • TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. 
  • TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice. 
  • The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. 
  • The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. 
  • The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target. 
  • The DVR gene family in embryonic development. 
  • The balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells. 
  • The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. 
  • The elusive philosopher's stone in young blood. 
  • The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. 
  • The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. 
  • The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. 
  • The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. 
  • The mammalian twisted gastrulation gene functions in foregut and craniofacial development. 
  • The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. 
  • The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. 
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. 
  • Tissue interactions pattern the mesenchyme of the embryonic mouse lung. 
  • Transcriptomic analysis of Nodal- and BMP-associated genes during juvenile development of the sea urchin Heliocidaris erythrogramma. 
  • Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. 
  • Trends in the use of bone morphogenetic protein as a substitute to autologous iliac crest bone grafting for spinal fusion procedures in the United States. 
  • Twist is an integrator of SHH, FGF, and BMP signaling. 
  • Vitamin D Levels and 1-Year Fusion Outcomes in Elective Spine Surgery: A Prospective Observational Study. 
  • Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery