Body Patterning

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  Subject Areas on Research

  • A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 
  • A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. 
  • A non-canonical Raf function is required for dorsal-ventral patterning during Drosophila embryogenesis. 
  • A reversible color polyphenism in American peppered moth (Biston betularia cognataria) caterpillars. 
  • A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation. 
  • A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. 
  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. 
  • Accessories to Limb Regeneration. 
  • An itch for things remote: The journey of Wnts. 
  • Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease. 
  • Archenteron precursor cells can organize secondary axial structures in the sea urchin embryo. 
  • Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. 
  • Arrays in rays: terminal addition in echinoderms and its correlation with gene expression. 
  • BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. 
  • BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. 
  • BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. 
  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem. 
  • Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation. 
  • Branching morphogenesis of the lung: new models for a classical problem. 
  • Branching out: origins of the sea urchin larval skeleton in development and evolution. 
  • Building and maintaining the epithelium of the lung. 
  • Cell signalling by microRNA165/6 directs gene dose-dependent root cell fate. 
  • Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. 
  • Chordin and noggin promote organizing centers of forebrain development in the mouse. 
  • Chordin is required for neural but not axial development in sea urchin embryos. 
  • Competition among body parts in the development and evolution of insect morphology. 
  • Conditional specification of endomesoderm. 
  • Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin. 
  • Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation. 
  • Developing pressures: fluid forces driving morphogenesis. 
  • Development of a straight vertebrate body axis. 
  • Developmental origin of peripheral ciliary band neurons in the sea urchin embryo. 
  • Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube. 
  • Ectoderm cell--ECM interaction is essential for sea urchin embryo skeletogenesis. 
  • Evolution of the gene network underlying wing polyphenism in ants. 
  • Expression of genes and proteins of the pax-six-eya-dach network in the metamorphic sea urchin: Insights into development of the enigmatic echinoderm body plan and sensory structures. 
  • FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Flying at the head of the pack: Wnt biology in Drosophila. 
  • Focus on butterfly eyespot development. 
  • Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. 
  • Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling. 
  • Genes with high penetrance for syndromic and non-syndromic autism typically function within the nucleus and regulate gene expression. 
  • Genetic divergence causes parallel evolution of flower color in Chilean Mimulus. 
  • Genetic network identification using convex programming. 
  • Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis. 
  • Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. 
  • Heterochrony in somitogenesis rate in a model marsupial, Monodelphis domestica. 
  • How does the mouse get its trunk? 
  • How the cytoskeleton helps build the embryonic body plan: models of morphogenesis from Drosophila. 
  • How the zebrafish gets its stripes. 
  • Hydra. 
  • Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone. 
  • Interspecific scaling patterns of talar articular surfaces within primates and their closest living relatives. 
  • Keeping at arm's length during regeneration. 
  • Left-right asymmetry in the sea urchin embryo: BMP and the asymmetrical origins of the adult. 
  • Lineage-specific laminar organization of cortical GABAergic interneurons. 
  • Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. 
  • Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems. 
  • Morphogenesis. 
  • Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. 
  • Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. 
  • Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. 
  • Multiple roles for Sox2 in the developing and adult mouse trachea. 
  • Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. 
  • Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. 
  • NIEHS/EPA Workshops. Pattern formation. 
  • Neonatal exposure to short days and low temperatures blunts stress response and yields low fluctuating asymmetry in Siberian hamsters. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan. 
  • Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. 
  • Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. 
  • PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos. 
  • Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression. 
  • Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway. 
  • Primary mesenchyme cell patterning during the early stages following ingression. 
  • RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. 
  • Radical alterations in the roles of homeobox genes during echinoderm evolution. 
  • Reconstruction and deconstruction of human somitogenesis in vitro. 
  • Regulatory logic and pattern formation in the early sea urchin embryo. 
  • Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo. 
  • Requirement for the vasa RNA helicase in gurken mRNA localization. 
  • Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. 
  • Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes. 
  • Root layers: complex regulation of developmental patterning. 
  • SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. 
  • Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm. 
  • Smad5 induces ventral fates in Xenopus embryo. 
  • Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase. 
  • Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. 
  • Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth. 
  • Spine Patterning Is Guided by Segmentation of the Notochord Sheath. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition. 
  • Synthetic Pattern Formation. 
  • Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. 
  • The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. 
  • The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity. 
  • The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish. 
  • The canonical Wnt pathway in embryonic axis polarity. 
  • The evolution of embryonic patterning mechanisms in animals. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. 
  • The genetic regulation of pigment cell development. 
  • The primary cilium as a Hedgehog signal transduction machine. 
  • The tardigrade Hypsibius dujardini, a new model for studying the evolution of development. 
  • The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. 
  • The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. 
  • Tissue interactions pattern the mesenchyme of the embryonic mouse lung. 
  • To branch or not to branch: the role of pre-patterning in lateral root formation. 
  • Toward a systems analysis of the root. 
  • Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. 
  • Transcriptomic analysis of the highly derived radial body plan of a sea urchin. 
  • Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. 
  • Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterning. 
  • Waves in Embryonic Development. 
  • Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis. 
  • Wingless signaling generates pattern through two distinct mechanisms. 
  • Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function. 
  • cDermo-1 misexpression induces dense dermis, feathers, and scales. 
  • mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. 
  • mirror encodes a novel PBX-class homeoprotein that functions in the definition of the dorsal-ventral border in the Drosophila eye. 
  • p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos. 
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  Keywords of People

  • Baugh, L. Ryan, Associate Professor of Biology, Biology
  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology