Area Under Curve

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  Subject Areas on Research

  • 2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects. 
  • A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss From Optic Disc Photographs. 
  • A Molecular Model for Predicting Overall Survival in Patients with Metastatic Clear Cell Renal Carcinoma: Results from CALGB 90206 (Alliance). 
  • A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM). 
  • A Phase 3 Study of Micafungin Versus Amphotericin B Deoxycholate in Infants With Invasive Candidiasis. 
  • A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma. 
  • A Phase I, Open-Label, Single-Dose Safety, Pharmacokinetic, and Tolerability Study of the Sumatriptan Iontophoretic Transdermal System in Adolescent Migraine Patients. 
  • A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents. 
  • A Regression Model for Prediction of Cesarean-Associated Blood Transfusion. 
  • A Simple Score That Predicts Paroxysmal Atrial Fibrillation on Outpatient Cardiac Monitoring after Embolic Stroke of Unknown Source. 
  • A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function. 
  • A blood-based gene expression test for obstructive coronary artery disease tested in symptomatic nondiabetic patients referred for myocardial perfusion imaging the COMPASS study. 
  • A challenge to the therapeutic nihilism of ESPAC-1. 
  • A combined index of structure and function for staging glaucomatous damage. 
  • A formalin-fixed paraffin-embedded (FFPE)-based prognostic signature to predict metastasis in clinically low risk stage I/II microsatellite stable colorectal cancer. 
  • A genetic algorithm for variable selection in logistic regression analysis of radiotherapy treatment outcomes. 
  • A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies. 
  • A machine learning approach to radiogenomics of breast cancer: a study of 922 subjects and 529 DCE-MRI features. 
  • A multi-dose pharmacokinetic study of dalteparin in haemodialysis patients. 
  • A national assessment of the epidemiology of severe fever with thrombocytopenia syndrome, China. 
  • A phase I study of estramustine, weekly docetaxel, and carboplatin chemotherapy in patients with hormone-refractory prostate cancer. 
  • A phase I study of the safety and pharmacokinetics of edotecarin (J-107088), a novel topoisomerase I inhibitor, in patients with advanced solid tumors. 
  • A phase I surrogate endpoint study of SU6668 in patients with solid tumors. 
  • A phase II trial of carboplatin/vinorelbine with pegfilgrastim support for the treatment of patients with advanced non-small cell lung cancer. 
  • A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans. 
  • A prospective, open-label study of single-dose ciprofloxacin absorption after chemotherapy in patients with malignancy. 
  • A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. 
  • A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis. 
  • A randomized, crossover phase 1 study to assess the effects of formulation (capsule vs tablet) and meal consumption on the bioavailability of dovitinib (TKI258). 
  • A risk calculator to predict adult attention-deficit/hyperactivity disorder: generation and external validation in three birth cohorts and one clinical sample. 
  • A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative. 
  • Absolute lymphocyte counts as prognostic indicators for immune thrombocytopenia outcomes in children. 
  • Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population. 
  • Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis. 
  • American Chinese glaucoma imaging study: a comparison of the optic disc and retinal nerve fiber layer in detecting glaucomatous damage. 
  • An adjusted two one-sided t-test for the assessment of bioequivalence with multiple doses. 
  • An expanded risk prediction model for lung cancer. 
  • Analysis of weight change and Borg rating of perceived exertion as measurements of runner health and safety during a 6-day, multistage, remote ultramarathon. 
  • Anidulafungin for neonatal hematogenous Candida meningoencephalitis: identification of candidate regimens for humans using a translational pharmacological approach. 
  • Antifungal pharmacodynamics: review of the literature and clinical applications. 
  • Artificial intelligence using deep learning to screen for referable and vision-threatening diabetic retinopathy in Africa: a clinical validation study. 
  • Assessing Ganglion Cell Layer Topography in Human Albinism Using Optical Coherence Tomography. 
  • Assessment of a new self-rating scale for post-traumatic stress disorder. 
  • Assessment of upper esophageal sphincter function on high-resolution manometry: identification of predictors of globus symptoms. 
  • Association between CK-MB Area Under the Curve and Tranexamic Acid Utilization in Patients Undergoing Coronary Artery Bypass Surgery. 
  • Association of high-dose cyclophosphamide, cisplatin, and carmustine pharmacokinetics with survival, toxicity, and dosing weight in patients with primary breast cancer. 
  • Associations between Cardiac Magnetic Resonance T1 Mapping Parameters and Ventricular Arrhythmia in Patients with Chagas Disease. 
  • Associations of cortisol/testosterone and cortisol/sex hormone-binding globulin ratios with atherosclerosis in middle-age women. 
  • Asymptotic distribution of ∆AUC, NRIs, and IDI based on theory of U-statistics. 
  • Automatic annotation of spatial expression patterns via sparse Bayesian factor models. 
  • Automatic diagnosis of pathological myopia from heterogeneous biomedical data. 
  • Automatic glaucoma diagnosis through medical imaging informatics. 
  • Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle. 
  • Bioavailability of IgG administered by the subcutaneous route. 
  • Bioequivalence review for drug interchangeability. 
  • Biological and analytical stability of a peripheral blood gene expression score for obstructive coronary artery disease in the PREDICT and COMPASS studies. 
  • Biomarker guided therapy for heart failure: focus on natriuretic peptides. 
  • Building knowledge in a complex preterm birth problem domain. 
  • CMR First-Pass Perfusion for Suspected Inducible Myocardial Ischemia. 
  • CRISP: Catheterization RISk score for Pediatrics: A Report from the Congenital Cardiac Interventional Study Consortium (CCISC). 
  • CT-Defined Prosthesis-Patient Mismatch Downgrades Frequency and Severity, and Demonstrates No Association With Adverse Outcomes After Transcatheter Aortic Valve Replacement. 
  • Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features? 
  • Can algorithmically assessed MRI features predict which patients with a preoperative diagnosis of ductal carcinoma in situ are upstaged to invasive breast cancer? 
  • Cardiac toxicity following high-dose cyclophosphamide, cisplatin, and BCNU (STAMP-I) for breast cancer. 
  • Cardiac troponin I for prediction of clinical outcomes and cardiac function through 3-month follow-up after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. 
  • Case-based reasoning computer algorithm that uses mammographic findings for breast biopsy decisions. 
  • Caspofungin: first approved agent in a new class of antifungals. 
  • Cell-free DNA analysis for noninvasive examination of trisomy. 
  • Characterization of adrenal lesions: comparison of 2D and 3D dual gradient-echo MR imaging at 3 T--preliminary results. 
  • Classification algorithms based on anterior segment optical coherence tomography measurements for detection of angle closure. 
  • Classification models for the prediction of clinicians' information needs. 
  • Clinical implications of referral bias in the diagnostic performance of exercise testing for coronary artery disease. 
  • Combining multiple features for error detection and its application in brain-computer interface. 
  • Comparative pharmacokinetics of voriconazole administered orally as either crushed or whole tablets. 
  • Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging. 
  • Comparing the value of mammographic features and genetic variants in breast cancer risk prediction. 
  • Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs. 
  • Comparison of PBTK model and biomarker based estimates of the internal dosimetry of acrylamide. 
  • Comparison of Scheimpflug imaging and spectral domain anterior segment optical coherence tomography for detection of narrow anterior chamber angles. 
  • Comparison of algorithms for detection of localised nerve fibre layer defects using scanning laser polarimetry. 
  • Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma. 
  • Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis. 
  • Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. 
  • Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles. 
  • Comparison of the diagnostic accuracies of the Spectralis, Cirrus, and RTVue optical coherence tomography devices in glaucoma. 
  • Comparison of the efficacy and safety of arformoterol 15 microg twice daily and arformoterol 30 microg once daily in COPD: a single-dose, multicenter, randomized, modified-blind, two-way crossover study. 
  • Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers. 
  • Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. 
  • Conditioning therapy with intravenous busulfan and cyclophosphamide (IV BuCy2) for hematologic malignancies prior to allogeneic stem cell transplantation: a phase II study. 
  • Creatinine versus cystatin C for renal function-based mortality prediction in an elderly cohort: The Northern Manhattan Study. 
  • Cross-sectional area for the calculation of carotid artery stenosis on computed tomographic angiography. 
  • Crowd-Sourced Assessment of Technical Skills for Validation of Basic Laparoscopic Urologic Skills Tasks. 
  • Cumulative exposure to CD8+ granzyme Bhi T cells is associated with reduced lung function early after lung transplantation. 
  • Cytokine profiles of preterm neonates with fungal and bacterial sepsis. 
  • Daily pain variations among patients with hand, hip, and knee osteoarthritis. 
  • Dalbavancin Pharmacokinetics and Safety in Children 3 Months to 11 Years of Age. 
  • Defining potency: a comparison of the International Index of Erectile Function short version and the Expanded Prostate Cancer Index Composite. 
  • Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. 
  • Detecting Retinal Nerve Fibre Layer Segmentation Errors on Spectral Domain-Optical Coherence Tomography with a Deep Learning Algorithm. 
  • Detecting glaucoma using automated pupillography. 
  • Determining the Threshold for HbA1c as a Predictor for Adverse Outcomes After Total Joint Arthroplasty: A Multicenter, Retrospective Study. 
  • Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes. 
  • Development and Validation of a Mortality Prediction Model for Patients Receiving 14 Days of Mechanical Ventilation. 
  • Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease. 
  • Development of a preoperative predictive model for major complications following adult spinal deformity surgery. 
  • Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid. 
  • Development of predictive models for all individual questions of SRS-22R after adult spinal deformity surgery: a step toward individualized medicine. 
  • Development, reliability and validation of a neurogenic bowel dysfunction score in pediatric patients with spina bifida. 
  • Developmental pharmacokinetic changes of Lamivudine in infants and children. 
  • Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography. 
  • Diagnostic ability of Heidelberg Retina Tomography in detecting glaucoma in a population setting: the Singapore Malay Eye Study. 
  • Diagnostic ability of macular ganglion cell inner plexiform layer measurements in glaucoma using swept source and spectral domain optical coherence tomography. 
  • Diagnostic accuracy of Fischer Senoscan Digital Mammography versus screen-film mammography in a diagnostic mammography population. 
  • Diagnostic accuracy of digital mammography in patients with dense breasts who underwent problem-solving mammography: effects of image processing and lesion type. 
  • Diagnostic accuracy of translucency rendering to differentiate polyps from pseudopolyps at 3D endoluminal CT colonography: a feasibility study. 
  • Diagnostic efficiency of the AUDIT-C in U.S. veterans with military service since September 11, 2001. 
  • Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. 
  • Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein. 
  • Differential immunoglobulin class-mediated responses to components of the U1 small nuclear ribonucleoprotein particle in systemic lupus erythematosus and mixed connective tissue disease. 
  • Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. 
  • Discrimination slope and integrated discrimination improvement - properties, relationships and impact of calibration. 
  • Discriminative value of inflammatory biomarkers for suspected sepsis. 
  • Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity. 
  • Disposition of vessel dilator and long-acting natriuretic peptide in healthy humans after a one-hour infusion. 
  • Diuretic strategies in patients with acute decompensated heart failure. 
  • Dosimetric Predictors of Patient-Reported Xerostomia and Dysphagia With Deintensified Chemoradiation Therapy for HPV-Associated Oropharyngeal Squamous Cell Carcinoma. 
  • Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters. 
  • Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study. 
  • Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. 
  • Effect of Multi Drug Resistance Protein 4 (MRP4) Inhibition on the Pharmacokinetics and Pharmacodynamics of Ciprofloxacin in Normal and Rats with LPS-Induced Inflammation. 
  • Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103). 
  • Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast. 
  • Effect of cyclosporin pharmacokinetics on renal allograft outcome in African-Americans. 
  • Effect of disease severity and optic disc size on diagnostic accuracy of RTVue spectral domain optical coherence tomograph in glaucoma. 
  • Effect of disease severity on the performance of Cirrus spectral-domain OCT for glaucoma diagnosis. 
  • Effect of dose reduction on the detection of mammographic lesions: a mathematical observer model analysis. 
  • Effect of patient history data on the prediction of breast cancer from mammographic findings with artificial neural networks. 
  • Effect of pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to fibrinolysis in acute myocardial infarction: the COMPlement inhibition in myocardial infarction treated with thromboLYtics (COMPLY) trial. 
  • Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris. 
  • Effects of pyridoxal-5'-phosphate (MC-1) in patients undergoing high-risk coronary artery bypass surgery: results of the MEND-CABG randomized study. 
  • Efficacy and safety of unfractionated heparin versus enoxaparin: a pooled analysis of ASSENT-3 and -3 PLUS data. 
  • Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. 
  • Elacytarabine, a novel 5'-elaidic acid derivative of cytarabine, and idarubicin combination is active in refractory acute myeloid leukemia. 
  • Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates. 
  • Enterohepatic recirculation model of irinotecan (CPT-11) and metabolite pharmacokinetics in patients with glioma. 
  • Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. 
  • Establishing magnetic resonance imaging as an accurate and reliable tool to diagnose and monitor esophageal cancer in a rat model. 
  • Evaluating iterative reconstruction performance in computed tomography. 
  • Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. 
  • Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study. 
  • Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision. 
  • Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography. 
  • Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events. 
  • Exposure Matching of Pediatric Anti-infective Drugs: Review of Drugs Submitted to the Food and Drug Administration for Pediatric Approval. 
  • External Validation for Acute Kidney Injury Severity Scores: A Multicenter Retrospective Study in 14 Japanese ICUs. 
  • Fluconazole dosing for the prevention or treatment of invasive candidiasis in young infants. 
  • Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma. 
  • Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. 
  • Genomic and molecular profiling predicts response to temozolomide in melanoma. 
  • Glucose and lipid effects of the ileal apical sodium-dependent bile acid transporter inhibitor GSK2330672: double-blind randomized trials with type 2 diabetes subjects taking metformin. 
  • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. 
  • Graphical assessment of incremental value of novel markers in prediction models: From statistical to decision analytical perspectives. 
  • Grid Binary LOgistic REgression (GLORE): building shared models without sharing data. 
  • Group-constrained sparse fMRI connectivity modeling for mild cognitive impairment identification. 
  • High Dimensional Variable Selection with Error Control. 
  • High-resolution mapping and characterization of open chromatin across the genome. 
  • How to interpret a small increase in AUC with an additional risk prediction marker: decision analysis comes through. 
  • Human Versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs. 
  • IMPROVED SPECIFICITY OF POLYPOIDAL CHOROIDAL VASCULOPATHY DIAGNOSIS USING A MODIFIED EVEREST CRITERIA. 
  • Identifying Nonalcoholic Fatty Liver Disease Advanced Fibrosis in the Veterans Health Administration. 
  • Identifying frailty in hospitalized older adults with significant coronary artery disease. 
  • Impact of missing data in evaluating artificial neural networks trained on complete data. 
  • Improving on the diagnostic characteristics of echocardiography for pulmonary hypertension. 
  • In-Depth Characterization and Validation of Human Urine Metabolomes Reveal Novel Metabolic Signatures of Lower Urinary Tract Symptoms. 
  • In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration. 
  • Incorporation of a Laguerre-Gauss channelized Hotelling observer for false-positive reduction in a mammographic mass CAD system. 
  • Incremental value of echocardiographic assessment beyond clinical evaluation for prediction of death and development of heart failure after high-risk myocardial infarction. 
  • Individual prediction of heart failure among childhood cancer survivors. 
  • Induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for regionally advanced unresectable stage III Non-small-cell lung cancer: Cancer and Leukemia Group B. 
  • Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate. 
  • Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. 
  • Inhibition of delta-protein kinase C by delcasertib as an adjunct to primary percutaneous coronary intervention for acute anterior ST-segment elevation myocardial infarction: results of the PROTECTION AMI Randomized Controlled Trial. 
  • Integrating factor analysis and a transgenic mouse model to reveal a peripheral blood predictor of breast tumors. 
  • Interfrontal angle for characterization of trigonocephaly: part 1: development and validation of a tool for diagnosis of metopic synostosis. 
  • Internal Validation of the Sepsis in Obstetrics Score to Identify Risk of Morbidity From Sepsis in Pregnancy. 
  • Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction. 
  • Is there a definition of remission in late-life depression that predicts later relapse? 
  • Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor. 
  • Large-scale identification of patients with cerebral aneurysms using natural language processing. 
  • Lens vault, thickness, and position in Chinese subjects with angle closure. 
  • Levels of office blood pressure and their operating characteristics for detecting masked hypertension based on ambulatory blood pressure monitoring. 
  • Limitations in the conventional assessment of the incremental value of predictors of cardiovascular risk. 
  • Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial. 
  • MRMR optimized classification for automatic glaucoma diagnosis. 
  • Machine-learning prediction of cancer survival: a retrospective study using electronic administrative records and a cancer registry. 
  • Measuring disease-free survival and cancer relapse using Medicare claims from CALGB breast cancer trial participants (companion to 9344). 
  • Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance. 
  • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. 
  • Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy. 
  • Misuse of DeLong test to compare AUCs for nested models. 
  • Model-based CT performance assessment and optimization for iodinated and noniodinated imaging tasks as a function of kVp and body size. 
  • Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR. 
  • Mouse handling limits the impact of stress on metabolic endpoints. 
  • Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer. 
  • Multicenter imaging outcomes study of The Cancer Genome Atlas glioblastoma patient cohort: imaging predictors of overall and progression-free survival. 
  • Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria. 
  • Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. 
  • Multicompartmental pharmacokinetic model of tenofovir delivery by a vaginal gel. 
  • Natural history of paclitaxel-associated acute pain syndrome: prospective cohort study NCCTG N08C1. 
  • Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease--dermatitis herpetiformis. 
  • Net reclassification index at event rate: properties and relationships. 
  • Nonpredictable pharmacokinetic behavior of high-dose cyclophosphamide in combination with cisplatin and 1,3-bis(2-chloroethyl)-1-nitrosourea. 
  • Novel Method Using Baseline Normalization and Area Under the Curve to Evaluate Differences in Outcome Between Treatment Groups and Application to Patients With Cervical Spondylotic Myelopathy Undergoing Anterior Versus Posterior Surgery. 
  • Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors. 
  • Novel model for predicting inpatient mortality after emergency admission to hospital in Singapore: retrospective observational study. 
  • Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures. 
  • Objective Assessment of the Interfrontal Angle for Severity Grading and Operative Decision-Making in Metopic Synostosis. 
  • Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios. 
  • Optimal weight in estimating and comparing areas under the receiver operating characteristic curve using longitudinal data. 
  • Optimized image acquisition for breast tomosynthesis in projection and reconstruction space. 
  • Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. 
  • Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial. 
  • Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. 
  • Pattern electroretinogram and psychophysical tests of visual function for discriminating between healthy and glaucoma eyes. 
  • Performance of current guidelines for coronary heart disease prevention: optimal use of the Framingham-based risk assessment. 
  • Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. 
  • Performance of the Paediatric Index of Mortality 3 and Paediatric Logistic Organ Dysfunction 2 Scores in Critically Ill Children. 
  • Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction: the COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial. 
  • Pharmacodynamics and pharmacokinetics of higher-dose, double-bolus eptifibatide in percutaneous coronary intervention. 
  • Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis. 
  • Pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients. 
  • Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant. 
  • Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects. 
  • Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects. 
  • Pharmacokinetic profile of ganciclovir after its oral administration and from its prodrug, valganciclovir, in solid organ transplant recipients. 
  • Pharmacokinetics and Safety of Micafungin in Infants Supported With Extracorporeal Membrane Oxygenation. 
  • Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease. 
  • Pharmacokinetics and clinical effects of sublingual triazolam in pediatric dental patients. 
  • Pharmacokinetics and clinical impact of all-trans retinoic acid in metastatic breast cancer: a phase II trial. 
  • Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia. 
  • Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints. 
  • Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection. 
  • Pharmacokinetics of Clindamycin in Obese and Nonobese Children. 
  • Pharmacokinetics of a new 10% intravenous immunoglobulin in patients receiving replacement therapy for primary immunodeficiency. 
  • Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection. 
  • Pharmacokinetics of doxorubicin administered i.v. as Myocet (TLC D-99; liposome-encapsulated doxorubicin citrate) compared with conventional doxorubicin when given in combination with cyclophosphamide in patients with metastatic breast cancer. 
  • Pharmacokinetics of once-daily IV busulfan as part of pretransplantation preparative regimens: a comparison with an every 6-hour dosing schedule. 
  • Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice. 
  • Phase 1 Study of Accelerated Hypofractionated Radiation Therapy With Concurrent Chemotherapy for Stage III Non-Small Cell Lung Cancer: CALGB 31102 (Alliance). 
  • Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies. 
  • Phase I and pharmacokinetic study of lonafarnib, SCH 66336, using a 2-week on, 2-week off schedule in patients with advanced solid tumors. 
  • Phase I clinical and plasma and cellular pharmacological study of topotecan without and with granulocyte colony-stimulating factor. 
  • Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis. 
  • Phase I study of the farnesyltransferase inhibitor lonafarnib with weekly paclitaxel in patients with solid tumors. 
  • Phase I study to determine the safety and pharmacokinetics of oral administration of TAS-102 in patients with solid tumors. 
  • Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study. 
  • Phase I/II Trial of Dose-Escalated Busulfan Delivered by Prolonged Continuous Infusion in Allogeneic Transplant Patients. 
  • Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma. 
  • Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. 
  • Phase II study of irinotecan plus cisplatin in patients with advanced non-small-cell lung cancer. 
  • Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. 
  • Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia. 
  • Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO. 
  • Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants. 
  • Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased. 
  • Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease. 
  • Polycyclic aromatic hydrocarbon and hypoxia exposures result in mitochondrial dysfunction in zebrafish. 
  • Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei. 
  • Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children. 
  • Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationships. 
  • Population pharmacokinetics of micafungin in neonates and young infants. 
  • Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. 
  • Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery. 
  • Predicting Emergency Visits and Hospital Admissions During Radiation and Chemoradiation: An Internally Validated Pretreatment Machine Learning Algorithm. 
  • Predicting cognitive decline in subjects at risk for Alzheimer disease by using combined cerebrospinal fluid, MR imaging, and PET biomarkers. 
  • Predicting error in detecting mammographic masses among radiology trainees using statistical models based on BI-RADS features. 
  • Predicting recurrent mitral regurgitation after mitral valve repair for severe ischemic mitral regurgitation. 
  • Predicting survival for metastatic spine disease: a comparison of nine scoring systems. 
  • Predicting the Risk of Readmission From Dehydration After Ileostomy Formation: The Dehydration Readmission After Ileostomy Prediction Score. 
  • Prediction of incident heart failure in general practice: the Atherosclerosis Risk in Communities (ARIC) Study. 
  • Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study. 
  • Predictive ability of perioperative atrial fibrillation risk indices in cardiac surgery patients: a retrospective cohort study. 
  • Predictive accuracy in the neuroprediction of rearrest. 
  • Predictive multivariate regression to increase the specificity of carotid duplex ultrasound for high-grade stenosis in asymptomatic patients. 
  • Predictors of adverse smoking outcomes in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. 
  • Prognostic model predicting metastatic castration-resistant prostate cancer survival in men treated with second-line chemotherapy. 
  • Prognostic usefulness of white blood cell count and temperature in acute myocardial infarction (from the CARDINAL Trial). 
  • Prognostic value of Rb-82 positron emission tomography myocardial perfusion imaging in coronary artery bypass patients. 
  • Prospective and External Evaluation of a Machine Learning Model to Predict In-Hospital Mortality of Adults at Time of Admission. 
  • Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia. 
  • Pulmonary toxicity in Stage III non-small cell lung cancer patients treated with high-dose (74 Gy) 3-dimensional conformal thoracic radiotherapy and concurrent chemotherapy following induction chemotherapy: a secondary analysis of Cancer and Leukemia Group B (CALGB) trial 30105. 
  • Quantitative classification of eyes with and without intermediate age-related macular degeneration using optical coherence tomography. 
  • Quantitative iris parameters and association with narrow angles. 
  • Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl. 
  • ROC methodology within a monitoring framework. 
  • RR-interval irregularity precedes ventricular fibrillation in ST elevation acute myocardial infarction. 
  • Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir. 
  • Rates of progressive retinal nerve fiber layer loss in glaucoma measured by scanning laser polarimetry. 
  • Real-time, computer-assisted quantification of plus disease in retinopathy of prematurity at the bedside. 
  • Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly. 
  • Recovery Kinetics: Comparison of Patients Undergoing Primary or Revision Procedures for Adult Cervical Deformity Using a Novel Area Under the Curve Methodology. 
  • Regulation of islet hormone release and gastric emptying by endogenous glucagon-like peptide 1 after glucose ingestion. 
  • Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD). 
  • Relationships of plasma C-peptide and gender to the urinary excretion of inositols in older people. 
  • Relevance vector machine and support vector machine classifier analysis of scanning laser polarimetry retinal nerve fiber layer measurements. 
  • Renal function with cyclosporine C2 monitoring, enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipients. 
  • Results of a phase II study of weekly paclitaxel plus carboplatin in advanced carcinoma of unknown primary origin: a reasonable regimen for the community-based clinic? 
  • Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor. 
  • Retinal nerve fiber layer reflectance for early glaucoma diagnosis. 
  • Risk Assessment in Patients with a Left Ventricular Assist Device Across INTERMACS Profiles Using Bayesian Analysis. 
  • Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci. 
  • Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine. 
  • Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. 
  • SW1PerS: Sliding windows and 1-persistence scoring; discovering periodicity in gene expression time series data. 
  • Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial. 
  • Safety and pharmacokinetics of multiple-dose anidulafungin in infants and neonates. 
  • Screening for narrow angles in the singapore population: evaluation of new noncontact screening methods. 
  • Selecting cases for whom additional tests can improve prognostication. 
  • Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. 
  • Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. 
  • Sequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer. 
  • Serum markers, myocardial marker content, and infarct size. 
  • Should we be anxious when assessing anxiety using the Beck Anxiety Inventory in clinical insomnia patients? 
  • Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities. 
  • Single Measurements of Carboxy-Terminal Fibroblast Growth Factor 23 and Clinical Risk Prediction of Adverse Outcomes in CKD. 
  • Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. 
  • Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam. 
  • Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation. 
  • Small-bowel obstruction: coronal reformations from isotropic voxels at 16-section multi-detector row CT. 
  • Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents. 
  • Spatial-temporal [¹⁸F]FDG-PET features for predicting pathologic response of esophageal cancer to neoadjuvant chemoradiation therapy. 
  • Steady-state pharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with end-stage renal disease receiving chronic dialysis. 
  • Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity. 
  • Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes. 
  • Superpixel classification based optic disc and optic cup segmentation for glaucoma screening. 
  • System for High-Intensity Evaluation During Radiation Therapy (SHIELD-RT): A Prospective Randomized Study of Machine Learning-Directed Clinical Evaluations During Radiation and Chemoradiation. 
  • The American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator Has a Role in Predicting Discharge to Post-Acute Care in Total Joint Arthroplasty. 
  • The ability of the electrocardiogram in left bundle branch block to detect myocardial scar determined by cardiovascular magnetic resonance. 
  • The bootstrap procedure in individual bioequivalence. 
  • The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases. 
  • The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients. 
  • The effect of draft DSM-V criteria on posttraumatic stress disorder prevalence. 
  • The effect of formulation and food consumption on the bioavailability of dovitinib (TKI258) in patients with advanced solid tumors. 
  • The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone. 
  • The effects of ambient lighting in chest radiology reading rooms. 
  • The effects of study design and spectrum bias on the evaluation of diagnostic accuracy of confocal scanning laser ophthalmoscopy in glaucoma. 
  • The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study. 
  • The use of Bowman's layer vertical topographic thickness map in the diagnosis of keratoconus. 
  • Time-dependent classification accuracy curve under marker-dependent sampling. 
  • Type 2 Diabetes Genetic Variants and Risk of Diabetic Retinopathy. 
  • Understanding increments in model performance metrics. 
  • Understanding indocyanine green angiography in polypoidal choroidal vasculopathy: the group experience with digital fundus photography and confocal scanning laser ophthalmoscopy. 
  • Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. 
  • Urinary-cell mRNA profile and acute cellular rejection in kidney allografts. 
  • Use of Machine Learning on Contact Lens Sensor-Derived Parameters for the Diagnosis of Primary Open-angle Glaucoma. 
  • Use of Population Pharmacokinetics and Electronic Health Records to Assess Piperacillin-Tazobactam Safety in Infants. 
  • Use of the complete blood cell count in late-onset neonatal sepsis. 
  • Using computer-extracted image features for modeling of error-making patterns in detection of mammographic masses among radiology residents. 
  • Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis. 
  • Validation of serum progesterone <35nmol/L as a predictor of miscarriage among women with threatened miscarriage. 
  • Validation of the American College of Surgeons National Surgical Quality Improvement Program Risk Model for Patients Undergoing Panniculectomy. 
  • Validation of the Cepstral Spectral Index of Dysphonia (CSID) as a Screening Tool for Voice Disorders: Development of Clinical Cutoff Scores. 
  • Validity of a new computer-aided diagnosis imaging program to quantify nuclear cataract from slit-lamp photographs. 
  • Validity, reliability and cut-offs of the Patient Health Questionnaire-9 as a screening tool for depression among patients living with epilepsy in Rwanda. 
  • Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome: CALGB 10105 (Alliance). 
  • Viability assessment by delayed enhancement cardiovascular magnetic resonance: will low-dose dobutamine dull the shine? 
  • Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial. 
  • WebGLORE: a web service for Grid LOgistic REgression. 
  • Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck. 
  • What Risk Factors Are Associated With Musculoskeletal Injury in US Army Rangers? A Prospective Prognostic Study. 
  • What to expect from net reclassification improvement with three categories. 
  • White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities. 
  • [Performance measures for prediction models and markers: evaluation of predictions and classifications]. 
• 

  Keywords of People

  • Allori, Alexander C, Assistant Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Cohen-Wolkowiez, Michael, Professor of Pediatrics, Pediatrics, Infectious Diseases
  • Craciunescu, Oana, Professor of Radiation Oncology, Radiation Oncology
  • Farsiu, Sina, Professor in the Department of Biomedical Engineering, Electrical and Computer Engineering
  • Halabi, Susan, Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Levy, Jerrold Henry, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Swaminathan, Madhav, Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • Tsalik, Ephraim, Associate Professor of Medicine, Molecular Genetics and Microbiology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology