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Subject Areas on Research
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A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.
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A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.
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A mutant PTH/PTHrP type I receptor in enchondromatosis.
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A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.
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A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
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A role for myocilin in receptor-mediated endocytosis.
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A second leaky splice-site mutation in the spastin gene.
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A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules.
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ABCs of erythroid mitochondrial iron uptake.
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ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.
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ALK1 regulates the internalization of endoglin and the type III TGF-β receptor.
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ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.
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Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis.
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Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
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Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
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Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.
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Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway.
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Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells.
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Allelic and locus heterogeneity in inherited venous malformations.
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Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death.
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Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells.
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Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.
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Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling.
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Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1.
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Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization.
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Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.
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Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.
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Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.
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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
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Beta-arrestin-mediated signaling regulates protein synthesis.
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Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.
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Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.
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Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling.
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Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor.
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Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight.
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CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis.
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CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.
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COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness.
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Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling.
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Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations.
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Cellular immune response to cryptic epitopes during therapeutic gene transfer.
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Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.
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Characterization of PDK2 activity against protein kinase B gamma.
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Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
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Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins.
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Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor.
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Coiled-coil targeting of myocilin to intracellular membranes.
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Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function.
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Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564.
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Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
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Conversion of Bcl-2 to a Bax-like death effector by caspases.
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Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.
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De novo mutations in ATP1A3 cause alternating hemiplegia of childhood.
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Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.
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Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.
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Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.
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Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex.
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Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
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Disruption of the toxic conformation of the expanded polyglutamine stretch leads to suppression of aggregate formation and cytotoxicity.
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Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection.
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Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking.
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Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.
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Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
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Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.
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Dual kinase-mediated regulation of PITK by CaMKII and GSK3.
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EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
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ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells.
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Endocytosis of the type III transforming growth factor-beta (TGF-beta) receptor through the clathrin-independent/lipid raft pathway regulates TGF-beta signaling and receptor down-regulation.
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Endoglin interacts with VEGFR2 to promote angiogenesis.
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Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors.
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Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding.
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Erbin suppresses the MAP kinase pathway.
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Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network.
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Expanded polyglutamine stretches form an 'aggresome'.
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Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1.
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Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain.
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Expression of alpha(2)-adrenergic receptor subtypes in prenatal rat spinal cord.
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Factor VIII Arg2304 --> His binds to phosphatidylserine and is a functional cofactor in the factor X-ase complex.
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Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB.
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Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.
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Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling.
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G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.
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G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
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G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR.
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GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation.
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Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
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Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation.
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Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments.
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HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions.
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HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.
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HIV vaccines. Magic of the occult?
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HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system.
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High-resolution mapping of intracellular fluctuations using carbon nanotubes.
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Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.
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Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.
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Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity.
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Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
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Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.
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Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.
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Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation.
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Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-1alpha.
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Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3.
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Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences.
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Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.
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Identification of novel murine- and human-specific RPGRIP1 splice variants with distinct expression profiles and subcellular localization.
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Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the V1/2 and V3 regions.
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In vitro pharmacology of clinically used central nervous system-active drugs as inverse H(1) receptor agonists.
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In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations.
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In vivo selection of tumor-targeting RNA motifs.
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Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1.
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Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor.
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Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.
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Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain.
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Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening.
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Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant.
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Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.
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Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.
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Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection.
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Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.
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Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
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L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity.
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L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1.
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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
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Light-Triggered Myosin Activation for Probing Dynamic Cellular Processes
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Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis.
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Localization of the activation gate for small conductance Ca2+-activated K+ channels.
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Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression.
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Metabolic Labeling of Inositol Phosphates and Phosphatidylinositols in Yeast and Mammalian Cells.
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Microtubule-driven multimerization recruits ase1p onto overlapping microtubules.
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MinK-dependent internalization of the IKs potassium channel.
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Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.
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Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis.
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Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity.
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Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.
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Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.
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Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit.
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Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain.
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N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.
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Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity.
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Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors.
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Neuronal ceroid lipofuscinosis: a common pathway?
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Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.
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New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties.
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Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation.
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Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells.
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Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
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PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.
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Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
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Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400.
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Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex.
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Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.
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Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.
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Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.
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Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.
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Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection.
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Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation.
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Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways.
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Prostaglandin F2 alpha receptors in the human trabecular meshwork.
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Protection from pathogenic SIV challenge using multigenic DNA vaccines.
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Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking.
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Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin.
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Proteomic identification of the cerebral cavernous malformation signaling complex.
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RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells.
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Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.
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Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
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Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.
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Regulation of ALK-1 signaling by the nuclear receptor LXRbeta.
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Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.
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Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.
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Regulation of TGF-β receptor hetero-oligomerization and signaling by endoglin.
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Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination.
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Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.
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Regulation of arrestin-3 phosphorylation by casein kinase II.
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Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.
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Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.
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Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
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Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism.
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Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells.
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Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
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Regulator of G-protein signalling expression and function in ovarian cancer cell lines.
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RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
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Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.
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Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
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Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP.
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Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90.
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Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.
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Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum.
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Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.
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Smads bind directly to the Jun family of AP-1 transcription factors.
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Spatial frequency-domain multiplexed microscopy for simultaneous, single-camera, one-shot, fluorescent, and quantitative-phase imaging
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Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.
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Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.
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Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.
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Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum.
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Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant.
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Studies of the neutralizing activity and avidity of anti-human immunodeficiency virus type 1 Env antibody elicited by DNA priming and protein boosting.
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Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia.
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Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery.
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Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.
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Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.
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Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription.
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TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
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TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
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Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
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Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
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Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.
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Terminal N-linked galactose is the primary receptor for adeno-associated virus 9.
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The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.
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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.
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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor.
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The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.
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The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.
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The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.
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The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions.
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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.
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The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2.
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The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors.
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The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish.
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Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.
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Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination.
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Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
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Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin.
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Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
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Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3.
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Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation.
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Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
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Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales.
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Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.
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beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.
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beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation.
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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
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Keywords of People
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Integrative Immunobiology
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McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology