Dose Fractionation

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  Subject Areas on Research

  • 73.6 Gy and beyond: hyperfractionated, accelerated radiotherapy for non-small-cell lung cancer. 
  • A limited-angle intrafraction verification (LIVE) system for radiation therapy. 
  • A phase III trial evaluating the combination of cisplatin, etoposide, and radiation therapy with or without tamoxifen in patients with limited-stage small cell lung cancer: Cancer and Leukemia Group B Study (9235). 
  • A rabbit irradiation platform for outcome assessment of lung stereotactic radiosurgery. 
  • A technique of using gated-CT images to determine internal target volume (ITV) for fractionated stereotactic lung radiotherapy. 
  • Adaptive replanning strategies accounting for shrinkage in head and neck IMRT. 
  • Adaptive stereotactic body radiation therapy planning for lung cancer. 
  • Addition of bevacizumab to standard radiation therapy and daily temozolomide is associated with minimal toxicity in newly diagnosed glioblastoma multiforme. 
  • American College of Radiology Appropriateness Criteria(®) treatment of stage I T1 glottic cancer. 
  • An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease. 
  • Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy. 
  • Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity. 
  • Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy: a preliminary report of a phase I dose escalation trial from the Carolina Conformal Therapy Consortium. 
  • Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy: report of a prospective phase I dose escalation trial from the Carolina Conformal Therapy Consortium. 
  • Chemopotentiation by ultrafractionated radiotherapy in glioblastoma resistant to conventional therapy. 
  • Combination external beam radiation and brachytherapy boost with androgen suppression for treatment of intermediate-risk prostate cancer: an initial report of CALGB 99809. 
  • Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone. 
  • Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy. 
  • Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: consensus, controversy, and conundrum. 
  • Cost Implications of an Evidence-Based Approach to Radiation Treatment After Lumpectomy for Early-Stage Breast Cancer. 
  • Definitive Stereotactic Body Radiotherapy (SBRT) for Extracranial Oligometastases: An International Survey of >1000 Radiation Oncologists. 
  • Definitive external beam irradiation in stage T1 and T2 carcinoma of the prostate. American College of Radiology. ACR Appropriateness Criteria. 
  • Does vocal cord fixation preclude nonsurgical management of laryngeal cancer? 
  • Dosimetric effect of intrafraction motion and residual setup error for hypofractionated prostate intensity-modulated radiotherapy with online cone beam computed tomography image guidance. 
  • Early results of prostate cancer radiation therapy: an analysis with emphasis on research strategies to improve treatment delivery and outcomes. 
  • Effect of neoadjuvant chemoradiation and surgical technique on recurrence of localized pancreatic cancer. 
  • Effect of the first day correction on systematic setup error reduction. 
  • Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis. 
  • Enhancement of radiotherapy by hyperthermia-regulated gene therapy. 
  • Etoposide, vincristine, and cyclosporin A with standard-dose radiation therapy in newly diagnosed diffuse intrinsic brainstem gliomas: a pediatric oncology group phase I study. 
  • Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: impact on future clinical trials. 
  • Exploring the Margin Recipe for Online Adaptive Radiation Therapy for Intermediate-Risk Prostate Cancer: An Intrafractional Seminal Vesicles Motion Analysis. 
  • Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo. 
  • Extreme hypofractionation for prostate cancer. 
  • Failure of radiation therapy in orbital xanthogranuloma. 
  • Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. 
  • Four-dimensional patient dose reconstruction for scanned ion beam therapy of moving liver tumors. 
  • Fractionated external-beam radiation therapy for meningiomas of the cavernous sinus. 
  • Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. 
  • Head and neck cancer. Introduction. 
  • Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. 
  • Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer. 
  • Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas. 
  • Hypofractionation for clinically localized prostate cancer. 
  • Hypofractionation for prostate cancer: a critical review. 
  • Hypofractionation for prostate cancer: tested and proven. 
  • Image-guided radiosurgery of head and neck cancers. 
  • Improvement of local control of T3 and T4 nasopharyngeal carcinoma by hyperfractionated radiotherapy and concomitant chemotherapy. 
  • In regard to Brenner et al. Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio) similar to late-responding normal tissue. 
  • Independent calculation of monitor units for VMAT and SPORT. 
  • Inferences about prostate intrafraction motion from pre- and posttreatment volumetric imaging. 
  • International practice survey on the management of brain metastases: Third International Consensus Workshop on Palliative Radiotherapy and Symptom Control. 
  • Lipiodol: a potential direct surrogate for cone-beam computed tomography image guidance in radiotherapy of liver tumor. 
  • Long-term results of an RTOG Phase II trial (00-19) of external-beam radiation therapy combined with permanent source brachytherapy for intermediate-risk clinically localized adenocarcinoma of the prostate. 
  • Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. 
  • Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells. 
  • Methods, safety, and early clinical outcomes of dose escalation using simultaneous integrated and sequential boosts in patients with locally advanced gynecologic malignancies. 
  • NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy. 
  • Neoadjuvant chemoradiation for rectal cancer reduces lymph node harvest in proctectomy specimens. 
  • New radiotherapy and chemoradiotherapy approaches for non-small-cell lung cancer. 
  • On the need for comprehensive validation of deformable image registration, investigated with a novel 3-dimensional deformable dosimeter. 
  • Optimizing monoscopic kV fluoro acquisition for prostate intrafraction motion evaluation. 
  • Palliative thoracic radiotherapy in advanced lung cancer: A single institution experience. 
  • Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy. 
  • Phase 1 Dose Escalation Study of Accelerated Radiation Therapy With Concurrent Chemotherapy for Locally Advanced Lung Cancer. 
  • Phase I study of concomitant chemoradiotherapy with irinotecan, 5-FU, and hydroxyurea for patients with advanced and/or recurrent head and neck cancer. 
  • Phase I study to determine the maximum-tolerated dose of radiation in standard daily and hyperfractionated-accelerated twice-daily radiation schedules with concurrent chemotherapy for limited-stage small-cell lung cancer. 
  • Phase II study of induction cisplatin and irinotecan followed by concurrent carboplatin, etoposide, and thoracic radiotherapy for limited-stage small-cell lung cancer, CALGB 30206. 
  • Physical and biological predictors of changes in whole-lung function following thoracic irradiation. 
  • Physics and imaging for targeting of oligometastases. 
  • Point/Counterpoint. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. 
  • Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. 
  • Predictors for pneumonitis during locoregional radiotherapy in high-risk patients with breast carcinoma treated with high-dose chemotherapy and stem-cell rescue. 
  • Preoperative chemoradiation for patients with locally advanced adenocarcinoma of the pancreas. 
  • Preoperative paclitaxel and concurrent rapid-fractionation radiation for resectable pancreatic adenocarcinoma: toxicities, histologic response rates, and event-free outcome. 
  • Preoperative radiation therapy and chemotherapy for pulmonary blastoma: a case report. 
  • Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation. 
  • Prospective trial of gross-total resection with Gliadel wafers followed by early postoperative Gamma Knife radiosurgery and conformal fractionated radiotherapy as the initial treatment for patients with radiographically suspected, newly diagnosed glioblastoma multiforme. 
  • Prostate intrafraction motion assessed by simultaneous kV fluoroscopy at MV delivery II: adaptive strategies. 
  • Prostate intrafraction motion assessed by simultaneous kilovoltage fluoroscopy at megavoltage delivery I: clinical observations and pattern analysis. 
  • Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system. 
  • Quantitative Approach to Failure Mode and Effect Analysis for Linear Accelerator Quality Assurance. 
  • Quantitative evaluation of cone-beam computed tomography in target volume definition for offline image-guided radiation therapy of prostate cancer. 
  • RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal. 
  • Radiation dose considerations in the palliative treatment of locally advanced adenocarcinoma of the pancreas. 
  • Radiation therapy for glioblastoma: Executive summary of an American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline. 
  • Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. 
  • Radiotherapy and concurrent chemotherapy for the treatment of locally advanced head and neck squamous cell carcinoma. 
  • Randomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer. 
  • Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012. 
  • Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. 
  • Rectal cancer: presentation with metastatic and locally advanced disease. American College of Radiology. ACR Appropriateness Criteria. 
  • Reducing biochemical recurrence rates in EBRT-treated prostate cancer patients: the influence of dose and dose per fraction. 
  • Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy. 
  • Report on a randomized trial comparing two forms of immobilization of the head for fractionated stereotactic radiotherapy. 
  • Severe dry eye syndrome after radiotherapy for head-and-neck tumors. 
  • Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial. 
  • Special report: workshop on 4D-treatment planning in actively scanned particle therapy--recommendations, technical challenges, and future research directions. 
  • Stage T3 prostate cancer: a nonrandomized comparison between definitive irradiation and induction hormonal manipulation plus prostatectomy. 
  • Stereotactic body radiation therapy for curative treatment of adrenal metastases. 
  • Stereotactic body radiation therapy for early-stage non-small cell lung cancer: Executive Summary of an ASTRO Evidence-Based Guideline. 
  • Stereotactic body radiotherapy for the treatment of oligometastatic renal cell carcinoma. 
  • Stereotactic radiotherapy for malignancies involving the trigeminal and facial nerves. 
  • Stereotactic radiotherapy for pulmonary metastases. 
  • Targeted radiotherapy for malignant gliomas. 
  • The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer. 
  • The chemoradiation paradigm in head and neck cancer. 
  • The ethics of hypofractionation for prostate cancer. 
  • The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. 
  • There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncology Group phase III trial comparing conventional vs. hyperfractionated radiotherapy. 
  • Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer. 
  • Treatment Planning and Delivery of Whole Brain Irradiation with Hippocampal Avoidance in Rats. 
  • Treatment of childhood acute lymphoblastic leukemia: results of Dana-Farber ALL Consortium Protocol 87-01. 
  • Treatment of head and neck cancer. 
  • Treatment sequencing for resectable pancreatic cancer: influence of early metastases and surgical complications on multimodality therapy completion and survival. 
  • Whole-breast radiation therapy: the long and short of it. 
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  Keywords of People

  • Esclamado, Ramon Mitra, Richard Hall Chaney, Sr. Professor of Otolaryngology, Surgery, Head and Neck Surgery and Communication Sciences
  • O'Daniel, Jennifer Colleen, Assistant Professor of Radiation Oncology, Radiation Oncology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Wu, Qingrong, Professor of Radiation Oncology, Radiation Oncology
  • Yoo, Sua, Associate Professor of Radiation Oncology, Radiation Oncology