Dietary Supplements

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  Subject Areas on Research

  • A Callosal Catastrophe: Toxic Leukoencephalopathy Associated with Thermogenic Weight Loss Supplement Use. 
  • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • A point-of-sale communications campaign to provide consumers safety information on drug-dietary supplement interactions: a pilot study. 
  • ALS Untangled No. 20: the Deanna protocol. 
  • Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series. 
  • Advising patients who seek complementary and alternative medical therapies for cancer. 
  • Age-related thymic atrophy in the guinea pig. 
  • American Society for Clinical Pharmacology and Therapeutics position statement on dietary supplement safety and regulation. 
  • Antioxidant and DNA methylation-related nutrients and risk of distal colorectal cancer. 
  • Ascorbic acid status in postmenopausal women with hormone replacement therapy. 
  • Association between low dietary folate intake and suboptimal cellular DNA repair capacity. 
  • Association of free vitamin D3 concentrations and asthma treatment failures in the VIDA Trial. 
  • Baseline Characteristics of the Vitamin D and Type 2 Diabetes (D2d) Study: A Contemporary Prediabetes Cohort That Will Inform Diabetes Prevention Efforts. 
  • Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. 
  • Body composition changes in preterm infants following hospital discharge: comparison with term infants. 
  • Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. 
  • Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. 
  • Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise. 
  • Branched-chain amino acid supplementation lowers perceived exertion but does not affect performance in untrained males. 
  • Breast cancer and dietary factors in Taiwanese women. 
  • Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders. 
  • Cancer-related fatigue. Clinical Practice Guidelines in Oncology. 
  • Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE). 
  • Catechins in dietary supplements and hepatotoxicity. 
  • Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. 
  • Chronic kidney disease, hypovitaminosis D, and mortality in the United States. 
  • Clinical evidence for pharmaconutrition in major elective surgery. 
  • Clinical implications for patients on antithrombotic therapy while taking supplements. 
  • Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements. 
  • Clinical risk factors for recurrent fracture after hip fracture: a prospective study. 
  • Coenzyme Q10 and Heart Failure: A State-of-the-Art Review. 
  • Common genetic determinants of vitamin D insufficiency: a genome-wide association study. 
  • Comparison of Glucosamine Absorption After Administration of Oral Liquid, Chewable, and Tablet Formulations to Dogs. 
  • Comparison of cost-effectiveness of vitamin D screening with that of universal supplementation in preventing falls in community-dwelling older adults. 
  • Comparison of dietary and lifestyle habits among stage III and metastatic colorectal cancer patients: findings from CALGB 89803 and CALGB 80405. 
  • Comparison of linear growth patterns in the first three years of life across two generations in Guatemala. 
  • Complementary and Alternative Medicine Use in United States Adults With Liver Disease. 
  • Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. 
  • Correlates of intake of folic acid-containing supplements among pregnant women. 
  • Cranberry use among pediatric nephrology patients. 
  • Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis. 
  • Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. 
  • Daily variability in mineral metabolites in CKD and effects of dietary calcium and calcitriol. 
  • Deflazacort in Duchenne muscular dystrophy: a comparison of two different protocols. 
  • Depression in Heart Failure: Beyond a SADHART. 
  • Design of the Trial to Assess Chelation Therapy (TACT). 
  • Dialogue with patient care organizations. 
  • Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. 
  • Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. 
  • Dietary prenatal choline supplementation alters postnatal hippocampal structure and function. 
  • Dietary supplement use among elderly, long-term cancer survivors. 
  • Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. 
  • Discovering the obvious, damaging the defenseless. 
  • Disparate results between proliferation rates of surgically excised prostate tumors and an in vitro bioassay using sera from a positive randomized controlled trial. 
  • Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial. 
  • Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. 
  • EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly. 
  • Early childhood nutrition, education and fertility milestones in Guatemala. 
  • Early childhood undernutrition increases risk of hearing loss in young adulthood in rural Nepal. 
  • Effect of Postnatal HIV Treatment on Clinical Mastitis and Breast Inflammation in HIV-Infected Breast-feeding Women. 
  • Effect of Selenium Supplementation on Recurrent Hyperthyroidism Caused by Graves' Disease: A Prospective Pilot Study. 
  • Effect of a high-fiber diet vs a fiber-supplemented diet on C-reactive protein level. 
  • Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial. 
  • Effect of hospital use of oral nutritional supplementation on length of stay, hospital cost, and 30-day readmissions among Medicare patients with COPD. 
  • Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. 
  • Effect of psyllium fiber supplementation on C-reactive protein: the trial to reduce inflammatory markers (TRIM). 
  • Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). 
  • Effect of vitamin D supplementation on blood pressure in blacks. 
  • Effects of Vitamin D Supplementation on C-peptide and 25-hydroxyvitamin D Concentrations at 3 and 6 Months. 
  • Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD. 
  • Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study. 
  • Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats. 
  • Effects of early childhood supplementation on the educational achievement of women. 
  • Effects of iodine supplementation during pregnancy on child growth and development at school age. 
  • Effects of nitrate supplementation via beetroot juice on contracting rat skeletal muscle microvascular oxygen pressure dynamics. 
  • Effects of potassium supplements on glucose metabolism in African Americans with prediabetes: a pilot trial. 
  • Effects of testosterone supplementation on body composition and lower-body muscle function during severe exercise- and diet-induced energy deficit: A proof-of-concept, single centre, randomised, double-blind, controlled trial. 
  • Efficacy of iron-supplement bars to reduce anemia in urban Indian women: a cluster-randomized controlled trial. 
  • Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency. 
  • Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study. 
  • Ensuring vitamin D supplementation in nursing home patients--a quality improvement project. 
  • Enteral High Fat-Polyunsaturated Fatty Acid Blend Alters the Pathogen Composition of the Intestinal Microbiome in Premature Infants with an Enterostomy. 
  • Enteral fish oil in critical illness: perspectives and systematic review. 
  • Ethanol metabolism modifies hepatic protein acylation in mice. 
  • Evaluating daily exposure to polychlorinated biphenyls and polybrominated diphenyl ethers in fish oil supplements. 
  • Evidence of a chemopreventive effect of progestin unrelated to ovulation on reproductive tract cancers in the egg-laying hen. 
  • Factors associated with prenatal folic acid and iron supplementation among 21,889 pregnant women in Northern Tanzania: a cross-sectional hospital-based study. 
  • Flax and flaxseed oil (Linum usitatissimum): a review by the Natural Standard Research Collaboration. 
  • Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. 
  • Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer. 
  • Folic acid supplementation and chronic kidney disease progression. 
  • Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). 
  • Folic acid supplementation enhances repair of the adult central nervous system. 
  • Folic acid throughout pregnancy: too much? 
  • Fruit, vegetable, and antioxidant intakes are lower in older adults with depression. 
  • Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration: Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study. 
  • Genetic and environmental factors are associated with serum 25-hydroxyvitamin D concentrations in older African Americans. 
  • Gestational vitamin A deficiency: a novel cause of sensorineural hearing loss in the developing world? 
  • Glutamine Supplementation in Parenteral Nutrition and Intensive Care Unit Patients: Are We Throwing the Baby Out With the Bathwater? 
  • Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. 
  • Herbal Supplements: Widely Used, Poorly Understood. 
  • Herbal supplements: Widely used, poorly understood. 
  • High dosage folic acid supplementation, oral cleft recurrence and fetal growth. 
  • Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. 
  • Hungry irony. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Hypertrophy of basal forebrain neurons and enhanced visuospatial memory in perinatally choline-supplemented rats. 
  • Identifying responders to oral iron supplementation in heart failure with a reduced ejection fraction: a post-hoc analysis of the IRONOUT-HF trial. 
  • Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. 
  • Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats. 
  • Impact of vitamin D supplementation on inflammatory markers in African Americans: results of a four-arm, randomized, placebo-controlled trial. 
  • Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. 
  • Increasing weight-bearing physical activity and calcium intake for bone mass growth in children and adolescents: a review of intervention trials. 
  • Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant. 
  • Innovations in bones and stones. 
  • Integrating Research With Clinical Practice: Keeping It Simple. 
  • Integrating complementary medicine into cardiovascular medicine. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). 
  • Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. 
  • Interventions to address chronic disease and HIV: strategies to promote exercise and nutrition among HIV-infected individuals. 
  • Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice. 
  • Introduction to the Newborn Screening, Diagnosis, and Treatment for Pompe Disease Guidance Supplement. 
  • Investigating the effects of resveratrol on chronically ischemic myocardium in a swine model of metabolic syndrome: a proteomics analysis. 
  • Involving communities in the design of clinical trial protocols: the BAN Study in Lilongwe, Malawi. 
  • L-carnitine. 
  • Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. 
  • Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial. 
  • Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 
  • Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4. 
  • Macular pigment optical density in the elderly: findings in a large biracial Midsouth population sample. 
  • Maternal and child nutritional supplementation are inversely associated with fasting plasma glucose concentration in young Guatemalan adults. 
  • Maternal and childhood nutrition and later blood pressure levels in young Guatemalan adults. 
  • Maternal dietary patterns are associated with risk of neural tube and congenital heart defects. 
  • Mathematical model insights into arsenic detoxification. 
  • Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan. 
  • Molecular mechanisms underlying the potentially adverse effects of folate. 
  • Monitoring the randomized trials of the Women's Health Initiative: the experience of the Data and Safety Monitoring Board. 
  • Multivitamin supplements and cataract prevention. 
  • Multivitamin/Mineral supplementation does not affect standardized assessment of academic performance in elementary school children. 
  • National survey of US oncologists' knowledge, attitudes, and practice patterns regarding herb and supplement use by patients with cancer. 
  • Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. 
  • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. 
  • Null association between vitamin D and PSA levels among black men in a vitamin D supplementation trial. 
  • Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. 
  • Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. 
  • Nutritional status of teenage female competitive figure skaters. 
  • Nutritional supplements for older adults: review and recommendations--Part II. 
  • Nutritional supplements for older adults: review and recommendations-part I. 
  • Omega-3 fatty acids for secondary prevention. 
  • Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. 
  • Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. 
  • Oral cleft prevention program (OCPP). 
  • Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial. 
  • Organic trace minerals and 25-hydroxycholecalciferol affect performance characteristics, leg abnormalities, and biomechanical properties of leg bones of turkeys. 
  • Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation. 
  • Osteoporosis screening and treatment among veterans with recent fracture after implementation of an electronic consult service. 
  • Oxaluria--the neglected stepchild of nephrolithiasis? 
  • Pediatric Integrative Medicine. 
  • Performance-enhancing sports supplements: role in critical care. 
  • Perinatal choline supplementation increases the threshold for chunking in spatial memory. 
  • Perioperative use of arginine-supplemented diets: a systematic review of the evidence. 
  • Perspective: Dietary protein needs of elderly people: protein supplementation as an effective strategy to counteract sarcopenia. 
  • Pharmacological and surgical treatments for obesity. 
  • Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia. 
  • Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917. 
  • Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. 
  • Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen. 
  • Plasma interleukin-6 is associated with psychological coronary risk factors: moderation by use of multivitamin supplements. 
  • Postoperative calcium supplementation in patients undergoing thyroidectomy. 
  • Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus. 
  • Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. 
  • Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior. 
  • Prenatal choline supplementation increases sensitivity to contextual processing of temporal information. 
  • Prenatal choline supplementation increases sensitivity to time by reducing non-scalar sources of variance in adult temporal processing. 
  • Prenatal choline supplementation protects against postnatal neurotoxicity. 
  • Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. 
  • Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats. 
  • Prevalence and Determinants of Suboptimal Vitamin D Levels in a Multiethnic Asian Population. 
  • Prevalence and correlates of vitamin and supplement usage among men with a family history of prostate cancer. 
  • Prevalence and predictors of multiple behavioral risk factors for colon cancer. 
  • Prevention and health services delivery. 
  • Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase. 
  • Prevention of chemotherapy and radiation toxicity with glutamine. 
  • Prevention of late PJI. 
  • Prospective study of protein-energy supplementation early in life and of growth in the subsequent generation in Guatemala. 
  • Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism. 
  • Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. 
  • Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus. 
  • Rationale and design of the Vitamin D and Type 2 Diabetes (D2d) study: a diabetes prevention trial. 
  • Re: Epilepsy-associated bone mineral density loss should be prevented. 
  • Recent Literature Update on Medication Risk in Older Adults, 2015-2016. 
  • Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. 
  • Relation of fish oil supplementation to markers of atherothrombotic risk in patients with cardiovascular disease not receiving lipid-lowering therapy. 
  • Relationships between vitamin and mineral supplement use, dietary intake, and dietary adequacy among adolescents. 
  • Reliability of causality assessment for drug, herbal and dietary supplement hepatotoxicity in the Drug-Induced Liver Injury Network (DILIN). 
  • Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease. 
  • Risk of mortality with vitamin E supplements: the Cache County study. 
  • Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis. 
  • Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise? 
  • Screening for vitamin D deficiency in adults: U.S. Preventive Services Task Force recommendation statement. 
  • Second trimester folate status and preterm birth. 
  • Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3. 
  • Serotonin shapes risky decision making in monkeys. 
  • Skeletal muscle loss: cachexia, sarcopenia, and inactivity. 
  • Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. 
  • Specialized Pro-Resolving Mediators from Omega-3 Fatty Acids Improve Amyloid-β Phagocytosis and Regulate Inflammation in Patients with Minor Cognitive Impairment. 
  • Supplement use among men with prostate cancer. 
  • Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women. 
  • The Role of Vitamin D in CKD Stages 3 to 4: Report of a Scientific Workshop Sponsored by the National Kidney Foundation. 
  • The association between vitamin D and cardiometabolic risk factors in children: a systematic review. 
  • The beehive and the merry-go-round in mineral metabolism. 
  • The cardiovascular patient's perceptions of complementary and alternative medicine. 
  • The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral L-carnitine. 
  • The effect of acute tryptophan depletion on emotional distraction and subsequent memory. 
  • The heart is just a muscle. 
  • The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. 
  • The role of zinc and iron-folic acid supplementation on early child temperament and eating behaviors in rural Nepal: a randomized controlled trial. 
  • To supplement or not to supplement: a cost-utility analysis of calcium and vitamin D repletion in patients after thyroidectomy. 
  • Trans-atlantic data harmonization in the classification of medicines and dietary supplements: a challenge for epidemiologic study and clinical research. 
  • Transposable elements: targets for early nutritional effects on epigenetic gene regulation. 
  • Treatment of alcoholic liver disease. 
  • Use of complementary and alternative medicine in men with family history of prostate cancer: a pilot study. 
  • Use of non-pharmacological therapies among patients with osteoarthritis. 
  • Use of vitamins, minerals, and nutritional supplements by participants in a chemoprevention trial. 
  • Vitamin D Supplementation and Prevention of Type 2 Diabetes. 
  • Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. 
  • Vitamin D status of black and white Americans and changes in vitamin D metabolites after varied doses of vitamin D supplementation. 
  • Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). 
  • Vitamin E supplement use and the incidence of cardiovascular disease and all-cause mortality in the Framingham Heart Study: Does the underlying health status play a role? 
  • Vitamin E, vitamin C, and exercise. 
  • Vitamin supplement use and breast cancer in a North Carolina population. 
  • Weight-loss talks: what works (and what doesn't). 
  • What you and your patients need to know about vitamin D. 
  • Zinc and Vitamin Supplementation in an Under-5 Indigenous Population of Guatemala: Influence of Lay Health Promoters in Decreasing Incidence of Diarrhea. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Cohen-Wolkowiez, Michael, Professor of Pediatrics, Pediatrics, Infectious Diseases
  • Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology
  • Lee, Richard Hsang-Young, Assistant Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition
  • Moorman, Patricia Gripka, Professor in Family Medicine and Community Health, Duke Cancer Institute
  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Distinguished Professor of Cardiology, Medicine, Clinical Pharmacology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Yancy Jr., William Samuel, Associate Professor of Medicine, Medicine, General Internal Medicine