Cytoprotection

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  Subject Areas on Research

  • A group randomized trial to improve safe use of nonsteroidal anti-inflammatory drugs. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. 
  • A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. 
  • Antifibrinolytic agents reduce tissue plasminogen activator-mediated neuronal toxicity in vitro. 
  • Bariatric Embolization: Pilot Study on the Impact of Gastroprotective Agents and Arterial Distribution on Ulceration Risk and Efficacy in a Porcine Model. 
  • Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. 
  • Cytoprotection for radiation-associated normal tissue injury. 
  • Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. 
  • Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells. 
  • ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. 
  • Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. 
  • Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. 
  • Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells. 
  • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. 
  • Exploratory composite endpoint demonstrates benefit of trilaciclib across multiple clinically meaningful components of myeloprotection in patients with small cell lung cancer. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis. 
  • Functional impact of global rare copy number variation in autism spectrum disorders. 
  • Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. 
  • Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. 
  • GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins. 
  • HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. 
  • Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. 
  • Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide. 
  • Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. 
  • Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. 
  • Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. 
  • Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome. 
  • Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress. 
  • NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells. 
  • Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress. 
  • Nrf2, a multi-organ protector? 
  • Nutritional pharmacology in surgery and critical care: 'you must unlearn what you have learned'. 
  • Prenatal choline supplementation protects against postnatal neurotoxicity. 
  • Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Protective role of ortho-substituted Mn(III) N-alkylpyridylporphyrins against the oxidative injury induced by tert-butylhydroperoxide. 
  • Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells. 
  • Statins and ischemic stroke severity: cytoprotection. 
  • Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor potential vanilloid-4. 
  • The quest for the "Holy Grail" of ischemic stroke cytoprotection: Statins may not be the answer. 
  • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. 
  • β-Arrestin and dishevelled coordinate biased signaling. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology