Neurodegenerative Diseases
-
Subject Areas on Research
-
A randomized study of combined zidovudine-lamivudine versus didanosine monotherapy in children with symptomatic therapy-naive HIV-1 infection. The Pediatric AIDS Clinical Trials Group Protocol 300 Study Team.
-
ACR Appropriateness Criteria Dementia and Movement Disorders.
-
ACR Appropriateness Criteria® Movement Disorders and Neurodegenerative Diseases.
-
ALSUntangled No. 47: RT001.
-
Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats.
-
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
-
Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
-
Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration.
-
An international perspective on advanced neuroimaging: cometh the hour or ivory tower?
-
An overview of naturally occurring histone deacetylase inhibitors.
-
Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
-
Anatomy of disturbed sleep in pallido-ponto-nigral degeneration.
-
ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease.
-
Authors' Reply.
-
Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.
-
Brain connectivity and visual attention.
-
CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice.
-
Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.
-
Childhood Lead Exposure and Adult Neurodegenerative Disease.
-
Chronic Lyme disease: the controversies and the science.
-
Coenzyme Q10: a review of its promise as a neuroprotectant.
-
Combining topographical and genetic cues to promote neuronal fate specification in stem cells.
-
Complement and CD4+ T cells drive context-specific corneal sensory neuropathy.
-
Converging pathways in neurodegeneration, from genetics to mechanisms.
-
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
-
Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.
-
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons.
-
Delivering therapy to target: improving the odds for successful drug development.
-
Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study
-
Development of ligands for in vivo imaging of cerebral nicotinic receptors.
-
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
-
Does Meditation Enhance Cognition and Brain Longevity?
-
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
-
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
-
Effect of oxidative stress on homer scaffolding proteins.
-
Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats.
-
Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network.
-
Expanded polyglutamine stretches form an 'aggresome'.
-
Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid.
-
Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.
-
Gene- and cell-based approaches for neurodegenerative disease.
-
Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.
-
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.
-
Gut microbial molecules in behavioural and neurodegenerative conditions.
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.
-
Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.
-
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration.
-
Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice.
-
Is OCT Angiography Useful in Neurodegenerative Diseases?
-
Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment.
-
Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype.
-
Longitudinal Analysis of the Retina and Choroid in Cognitively Normal Individuals at Higher Genetic Risk of Alzheimer Disease.
-
MN-166 (ibudilast) in amyotrophic lateral sclerosis in a Phase IIb/III study: COMBAT-ALS study design.
-
Metals in our minds: therapeutic implications for neurodegenerative disorders.
-
Microglia Drive Pockets of Neuroinflammation in Middle Age.
-
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
-
Microglial-neuronal interactions during neurodegenerative diseases.
-
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
-
Minimally invasive versus open fusion for Grade I degenerative lumbar spondylolisthesis: analysis of the Quality Outcomes Database.
-
Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease.
-
Myeloid Cells in the Central Nervous System.
-
NPY and chronic neurodegenerative disease.
-
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.
-
Neuroprotection mediated through estrogen receptor-alpha in astrocytes.
-
Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences.
-
Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review.
-
PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.
-
Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability.
-
Plasma Neurofilament Light Chain as a Translational Biomarker of Aging and Neurodegeneration in Dogs.
-
Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease.
-
Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.
-
Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila.
-
Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration.
-
Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains.
-
Quantitative measurement of postural sway in mouse models of human neurodegenerative disease.
-
ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation.
-
SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases.
-
Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration.
-
Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.
-
Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development.
-
Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders.
-
Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration.
-
Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.
-
Standards for quantification of EMG and neurography.
-
Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders.
-
Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans.
-
Structural variants in SNCA gene and the implication to synucleinopathies.
-
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
-
Subacute combined degeneration due to copper deficiency.
-
TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities.
-
Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.
-
The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease.
-
The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for Ocular and Non-Ocular Neurodegenerative Diseases.
-
The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration.
-
The cell and molecular biology of glaucoma: common neurodegenerative pathways and relevance to glaucoma.
-
The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration.
-
The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation.
-
The engine driving the ship: metabolic steering of cell proliferation and death.
-
The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.
-
The role of oxidative damage in mitochondria during aging: a review.
-
Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study.
-
Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.
-
Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length.
-
Translating protein phosphatase research into treatments for neurodegenerative diseases.
-
Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.
-
Trends in the use of feeding tubes in North Carolina hospitals.
-
Triplet repeats form secondary structures that escape DNA repair in yeast.
-
Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders.
-
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.
-
Using human neural stem cells to model neurological disease.
-
Ventricular enlargement in poor-outcome schizophrenia.
-
Whether ionizing radiation is a risk factor for schizophrenia spectrum disorders?
-
lncRNAs, DNA Methylation, and the Pathobiology of Exfoliation Glaucoma.
-
mNos2 deletion and human NOS2 replacement in Alzheimer disease models.
-
α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.
-
Keywords of People
-
-
-
Berger, Miles,
Associate Professor of Anesthesiology,
Duke Science & Society
-
Bowes Rickman, Catherine,
George and Geneva Boguslavsky Distinguished Professor of Eye Research,
Cell Biology
-
Ferreira, Paulo Alexandre,
Associate Professor in Ophthalmology,
Pathology
-
Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Science & Society
-
Liu, Andrew John,
Assistant Professor of Neurology,
Pathology
-
Velkey, John Matthew,
Assistant Professor of the Practice of Medical Education in the Department of Cell Biology,
Cell Biology