Neurodegenerative Diseases

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  Subject Areas on Research

  • A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features. 
  • A randomized study of combined zidovudine-lamivudine versus didanosine monotherapy in children with symptomatic therapy-naive HIV-1 infection. The Pediatric AIDS Clinical Trials Group Protocol 300 Study Team. 
  • ALSUntangled No. 47: RT001. 
  • Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Adult neurogenesis as a potential therapy for neurodegenerative diseases. 
  • Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan. 
  • Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration. 
  • An international perspective on advanced neuroimaging: cometh the hour or ivory tower? 
  • An overview of naturally occurring histone deacetylase inhibitors. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Anatomy of disturbed sleep in pallido-ponto-nigral degeneration. 
  • Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? 
  • Biallelic SQSTM1 mutations in early-onset, variably progressive neurodegeneration. 
  • Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. 
  • Brain connectivity and visual attention. 
  • Brain stimulation in neuropsychiatry. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • CLN3 defines a novel antiapoptotic pathway operative in neurodegeneration and mediated by ceramide. 
  • Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. 
  • Caregivers of people with neurodegenerative diseases: profile and unmet needs from a population-based survey in South Australia. 
  • Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease--therapeutic potential. 
  • Childhood Lead Exposure and Adult Neurodegenerative Disease. 
  • Chronic Lyme disease: the controversies and the science. 
  • Chronic refractory dyspnoea--evidence based management. 
  • Coenzyme Q10: a review of its promise as a neuroprotectant. 
  • Combining topographical and genetic cues to promote neuronal fate specification in stem cells. 
  • Complement and CD4+ T cells drive context-specific corneal sensory neuropathy. 
  • Converging pathways in neurodegeneration, from genetics to mechanisms. 
  • Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction. 
  • Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. 
  • Delivering therapy to target: improving the odds for successful drug development. 
  • Development of ligands for in vivo imaging of cerebral nicotinic receptors. 
  • Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. 
  • Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury? 
  • Does Meditation Enhance Cognition and Brain Longevity? 
  • Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? 
  • Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Effect of oxidative stress on homer scaffolding proteins. 
  • Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats. 
  • Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain? 
  • Endoplasmic reticulum stress response and neurodegeneration. 
  • Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Expanded polyglutamine stretches form an 'aggresome'. 
  • Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration. 
  • Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. 
  • Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. 
  • GIT2-A keystone in ageing and age-related disease. 
  • Gene- and cell-based approaches for neurodegenerative disease. 
  • Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans. 
  • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. 
  • Haemoglobin, magnetic resonance imaging markers and cognition: a subsample of population-based study. 
  • Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases. 
  • High throughput screening for neurodegeneration and complex disease phenotypes. 
  • Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8. 
  • Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration. 
  • Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice. 
  • Is OCT Angiography Useful in Neurodegenerative Diseases? 
  • Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment. 
  • Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype. 
  • Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. 
  • Metals in our minds: therapeutic implications for neurodegenerative disorders. 
  • Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. 
  • Microglial-neuronal interactions during neurodegenerative diseases. 
  • Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease. 
  • Minimally invasive versus open fusion for Grade I degenerative lumbar spondylolisthesis: analysis of the Quality Outcomes Database. 
  • Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. 
  • Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter. 
  • Multivariate MR biomarkers better predict cognitive dysfunction in mouse models of Alzheimer's disease. 
  • Myeloid Cells in the Central Nervous System. 
  • NPY and chronic neurodegenerative disease. 
  • Neurofilament cytoskeleton disruption does not modify accumulation of trophic factor mRNA. 
  • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. 
  • Nitrosative stress in the ER: a new role for S-nitrosylation in neurodegenerative diseases. 
  • Organophosphorus ester-induced chronic neurotoxicity. 
  • PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction. 
  • Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability. 
  • Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease. 
  • Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. 
  • Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration. 
  • Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. 
  • Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. 
  • ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation. 
  • Recognition of handwriting from electromyography. 
  • SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases. 
  • Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration. 
  • Small molecule intervention in microtubule-associated human disease. 
  • Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. 
  • Standards for quantification of EMG and neurography. 
  • Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders. 
  • Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. 
  • Structural variants in SNCA gene and the implication to synucleinopathies. 
  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 
  • Subacute combined degeneration due to copper deficiency. 
  • Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1). 
  • TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations. 
  • TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities. 
  • Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease. 
  • The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease. 
  • The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. 
  • The cell and molecular biology of glaucoma: common neurodegenerative pathways and relevance to glaucoma. 
  • The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration. 
  • The effect of inflammatory cell-derived MCP-1 loss on neuronal survival during chronic neuroinflammation. 
  • The engine driving the ship: metabolic steering of cell proliferation and death. 
  • The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2. 
  • The role of oxidative damage in mitochondria during aging: a review. 
  • Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study. 
  • Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study. 
  • Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length. 
  • Translating protein phosphatase research into treatments for neurodegenerative diseases. 
  • Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. 
  • Trends in the use of feeding tubes in North Carolina hospitals. 
  • Triplet repeats form secondary structures that escape DNA repair in yeast. 
  • Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference. 
  • Upward transtentorial herniation, hydrocephalus, and cerebellar edema in hypertensive encephalopathy. 
  • Using human neural stem cells to model neurological disease. 
  • Ventricular enlargement in poor-outcome schizophrenia. 
  • Whether ionizing radiation is a risk factor for schizophrenia spectrum disorders? 
  • ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss. 
  • lncRNAs, DNA Methylation, and the Pathobiology of Exfoliation Glaucoma. 
  • mNos2 deletion and human NOS2 replacement in Alzheimer disease models. 
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration. 
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  Keywords of People

  • Berger, Miles, Associate Professor of Anesthesiology, Duke Science & Society
  • Bowes Rickman, Catherine, Professor of Ophthalmology, Cell Biology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Kearney, Hutton Moore, Assistant Consulting Professor in the Department of Pathology, Pathology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • Liu, Andrew John, Assistant Professor of Neurology, Neurology, Behavioral Neurology
  • Velkey, John Matthew, Assistant Professor of the Practice of Medical Education in the Department of Cell Biology, Cell Biology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology