Quantitative Trait, Heritable

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  Subject Areas on Research

  • 3D phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture. 
  • A gain-of-function polymorphism controlling complex traits and fitness in nature. 
  • A genetic map in the Mimulus guttatus species complex reveals transmission ratio distortion due to heterospecific interactions. 
  • A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence. 
  • A genome-wide association study for extremely high intelligence. 
  • A novel meiotic drive locus almost completely distorts segregation in mimulus (monkeyflower) hybrids. 
  • A quantitative genetic analysis of male sexual traits distinguishing the sibling species Drosophila simulans and D. sechellia. 
  • Analysis of principal component based quantitative phenotypes for alcoholism. 
  • Analysis of shared heritability in common disorders of the brain. 
  • Behavior genetics and postgenomics. 
  • Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies. 
  • Bootstrap calibration of TRANSMIT for informative missingness of parental genotype data. 
  • Challenges in elucidating the genetics of diabetic retinopathy. 
  • Comparative analysis of quantitative trait loci controlling glucosinolates, myrosinase and insect resistance in Arabidopsis thaliana. 
  • Comparative quantitative trait loci mapping of aliphatic, indolic and benzylic glucosinolate production in Arabidopsis thaliana leaves and seeds. 
  • Consequences of recombination rate variation on quantitative trait locus mapping studies. Simulations based on the Drosophila melanogaster genome. 
  • Contribution of chromosomal polymorphisms to the G-matrix of Mimulus guttatus. 
  • Correlations between physical and chemical defences in plants: tradeoffs, syndromes, or just many different ways to skin a herbivorous cat? 
  • Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. 
  • Dependence of morphometric allometries on the growth kinetics of body parts. 
  • Detection and localization of a single binary trait locus in experimental populations. 
  • Disease Heritability Inferred from Familial Relationships Reported in Medical Records. 
  • Dissecting the architecture of a quantitative trait locus in yeast. 
  • Diversification and the evolution of dispersal ability in the tribe Brassiceae (Brassicaceae). 
  • Do thick leaves avoid thermal damage in critically low wind speeds? 
  • Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. 
  • EMK: a novel program for family-based allelic and genotypic association tests on quantitative traits. 
  • Effects of plant sex on range distributions and allocation to reproduction. 
  • Ethical, legal, and social implications of biobanks for genetics research. 
  • Evolution of sexual systems, dispersal strategies and habitat selection in the liverwort genus Radula. 
  • Evolution. Chaperones as buffering agents? 
  • Explaining the heritability of an ecologically significant trait in terms of individual quantitative trait loci. 
  • False positive rates in a genomic screen for complex quantitative traits. 
  • Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators. 
  • Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5. 
  • Functional trait evolution in Sphagnum peat mosses and its relationship to niche construction. 
  • Genes, behavior, and behavior genetics. 
  • Genetic architecture of a morphological shape difference between two Drosophila species. 
  • Genetic divergence causes parallel evolution of flower color in Chilean Mimulus. 
  • Genetic evaluation and application of posterior cranial fossa traits as endophenotypes for Chiari type I malformation. 
  • Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment. 
  • Genetic linkage of hyper-IgE syndrome to chromosome 4. 
  • Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. 
  • Genetics and evolution of insect resistance in Arabidopsis. 
  • Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. 
  • Genome-wide association studies for complex traits: consensus, uncertainty and challenges. 
  • Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. 
  • Genome-wide linkage scan for prostate cancer aggressiveness loci using families from the University of Michigan Prostate Cancer Genetics Project. 
  • Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. 
  • Heritability estimates of endophenotypes of long and health life: the Long Life Family Study. 
  • Identification of quantitative trait loci and a candidate locus for freezing tolerance in controlled and outdoor environments in the overwintering crucifer Boechera stricta. 
  • Impact of measurement error on testing genetic association with quantitative traits. 
  • Incorporating larger families in identity-by-descent based linkage analysis. 
  • Invasive species' leaf traits and dissimilarity from natives shape their impact on nitrogen cycling: a meta-analysis. 
  • Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. 
  • Local adaptation across a climatic gradient despite small effective population size in the rare sapphire rockcress. 
  • Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. 
  • On the association between genes and complex traits. 
  • Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits. 
  • Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide. 
  • Penalized multimarker vs. single-marker regression methods for genome-wide association studies of quantitative traits. 
  • Phylotranscriptomic analysis of the origin and early diversification of land plants. 
  • Population Selection and Sequencing of Caenorhabditis elegans Wild Isolates Identifies a Region on Chromosome III Affecting Starvation Resistance. 
  • Quantitative assessment of autism symptom-related traits in probands and parents: Broader Phenotype Autism Symptom Scale. 
  • Redefining fine roots improves understanding of below-ground contributions to terrestrial biosphere processes. 
  • Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies. 
  • SeqSIMLA2: simulating correlated quantitative traits accounting for shared environmental effects in user-specified pedigree structure. 
  • Sequential sib-pair and association studies to detect genes in quantitative traits. 
  • Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children. 
  • Study design for genetic analysis in the Jackson Heart Study. 
  • Testing the effect of rare compound-heterozygous and recessive mutations in case--parent sequencing studies. 
  • The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. 
  • The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. 
  • The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci. 
  • The genetic bases of divergence in desiccation and starvation resistance among tropical and temperate populations of Drosophila melanogaster. 
  • The genetics of reproductive isolation and the potential for gene exchange between Drosophila pseudoobscura and D. persimilis via backcross hybrid males. 
  • The influence of neighbor relatedness on multilevel selection in the Great Lakes sea rocket. 
  • The molecular basis of quantitative genetic variation in central and secondary metabolism in Arabidopsis. 
  • The neurobiology of individual differences in complex behavioral traits. 
  • Tissue-specific genetic control of splicing: implications for the study of complex traits. 
  • Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans. 
  • Understanding rice adaptation to varying agro-ecosystems: trait interactions and quantitative trait loci. 
  • Unraveling genetic origin of aging-related traits: evolving concepts. 
  • Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. 
  • What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? 
  • What's good for you may be good for me: evidence for adaptive introgression of multiple traits in wild sunflower. 
  • fastJT: An R package for robust and efficient feature selection for machine learning and genome-wide association studies. 
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  Keywords of People

  • Li, Yi-Ju, Professor of Biostatistics and Bioinformatics, Duke Molecular Physiology Institute
  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology