Loss of Heterozygosity

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  Subject Areas on Research

  • 5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. 
  • APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q. 
  • Aberrant promoter methylation of multiple genes in non-small cell lung cancers. 
  • Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma. 
  • Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. 
  • Allele loss on chromosome 1p36 in epithelial ovarian cancers. 
  • Allelic loss on chromosome 6Q in primary prostate cancer. 
  • Allelic loss on chromosome arm 8p: analysis of sporadic epithelial ovarian tumors. 
  • Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q. 
  • Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro. 
  • CD45-deficient severe combined immunodeficiency caused by uniparental disomy. 
  • Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone. 
  • Characterization of frequently deleted 6q locus in prostate cancer. 
  • Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. 
  • Characterization of sporadic colon cancer by patterns of genomic instability. 
  • Chromosomal comparative genomic hybridization abnormalities in early- and late-onset human breast cancers: correlation with disease progression and TP53 mutations. 
  • Clonality of combined tumors. 
  • Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. 
  • Comparison of molecular markers in a cohort of patients with chronic myeloproliferative disorders. 
  • Comprehensive DNA copy number profiling of meningioma using a chromosome 1 tiling path microarray identifies novel candidate tumor suppressor loci. 
  • Comprehensive analysis of chromosome 1p deletions in neuroblastoma. 
  • Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia. 
  • Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers. 
  • Deciphering Elevated Microsatellite Alterations at Selected Tetra/Pentanucleotide Repeats, Microsatellite Instability, and Loss of Heterozygosity in Colorectal Cancers. 
  • Decreased E-cadherin expression correlates with higher stage of Wilms' tumors. 
  • Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma. 
  • Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. 
  • Detailed molecular analysis of 1p36 in neuroblastoma. 
  • Diagnostic markers in paediatric medulloblastoma: a Paediatric Oncology Group Study. 
  • Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations. 
  • Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity. 
  • Evidence for loss of heterozygosity of 5q in sporadic haemangiomas: are somatic mutations involved in haemangioma formation? 
  • Exome sequencing of liver fluke-associated cholangiocarcinoma. 
  • Familial chordoma, a tumor of notochordal remnants, is linked to chromosome 7q33. 
  • Fine mapping of Wilms' tumors with 16q loss of heterozygosity localizes the putative tumor suppressor gene to a region of 6.7 megabases. 
  • Frequency of germline and somatic BRCA1 mutations in ovarian cancer. 
  • Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. 
  • From the Cover: mitotic gene conversion events induced in G1-synchronized yeast cells by gamma rays are similar to spontaneous conversion events. 
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. 
  • Gene expression profiling and genetic markers in glioblastoma survival. 
  • Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genetic changes in contralateral bronchioloalveolar carcinomas of the lung. 
  • Genome-wide high-resolution mapping of UV-induced mitotic recombination events in Saccharomyces cerevisiae. 
  • Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae. 
  • Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells. 
  • Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. 
  • Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. 
  • Genomic landscapes of breast fibroepithelial tumors. 
  • Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae. 
  • Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11. 
  • High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer. 
  • High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events. 
  • High-resolution mapping of spontaneous mitotic recombination hotspots on the 1.1 Mb arm of yeast chromosome IV. 
  • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. 
  • Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. 
  • Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors. 
  • Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features. 
  • Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence. 
  • Loss of heterozygosity at chromosome segment Xq25-26.1 in advanced human ovarian carcinomas. 
  • Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury. 
  • Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer. 
  • Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer. 
  • Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations. 
  • M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis. 
  • MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma. 
  • Microsatellite instability and loss of heterozygosity at chromosomal location 18q: prospective evaluation of biomarkers for stages II and III colon cancer--a study of CALGB 9581 and 89803. 
  • Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. 
  • Molecular analysis of synchronous and metachronous tumors of the lung: impact on management and prognosis. 
  • Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. 
  • Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. 
  • Molecular markers of prognosis in astrocytic tumors. 
  • Molecular pathogenesis of malignant gliomas. 
  • Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications. 
  • Morphologic and molecular genetic aspects of oligodendroglial neoplasms. 
  • Mutagenicity and carcinogenicity of biological reactive intermediate's derived from a "non-genotoxic" carcinogen. 
  • Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. 
  • Mutations in CIC and FUBP1 contribute to human oligodendroglioma. 
  • Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy. 
  • Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications. 
  • Nonrandom distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae. 
  • Novel congenital myopathy locus identified in Native American Indians at 12q13.13-14.1. 
  • Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution in Saccharomyces cerevisiae. 
  • PTEN gene mutations are seen in high-grade but not in low-grade gliomas. 
  • Pathogenesis of hemangioma. 
  • Pathogenic Germline Variants in 10,389 Adult Cancers. 
  • Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling. 
  • Predictors of differential response to induction therapy in high-risk neuroblastoma: A report from the Children's Oncology Group (COG). 
  • Prevalence of deleterious ATM germline mutations in gastric cancer patients. 
  • Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms. 
  • Rapid global expansion of the fungal disease chytridiomycosis into declining and healthy amphibian populations. 
  • Reciprocal uniparental disomy in yeast. 
  • Recombination between homologous chromosomes induced by unrepaired UV-generated DNA damage requires Mus81p and is suppressed by Mms2p. 
  • Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. 
  • Regulation of the metastasis suppressor gene MKK4 in ovarian cancer. 
  • Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1. 
  • Somatic mutations in VHL germline deletion kindred correlate with mild phenotype. 
  • Surgical treatment of malignant esophageal tumors in PUMC Hospital. 
  • Survival analysis of presumptive prognostic markers among oligodendrogliomas. 
  • TbetaRIII suppresses non-small cell lung cancer invasiveness and tumorigenicity. 
  • The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. 
  • The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer. 
  • Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level. 
  • Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome. 
  • U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. 
  • Uveal melanocytomas: genetic comparison with uveal and dermal melanomas. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology