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Subject Areas on Research
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A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
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AQP2 is a substrate for endogenous PP2B activity within an inner medullary AKAP-signaling complex.
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Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
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Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.
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Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway.
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Acute graft-versus-host disease: are we close to bringing the bench to the bedside?
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Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.
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Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway.
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Angiotensin II: an immune costimulator?
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Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species.
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Antifungal drug resistance evoked via RNAi-dependent epimutations.
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Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
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Antisense repression in Cryptococcus neoformans as a laboratory tool and potential antifungal strategy.
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Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling.
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Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics.
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Biologics in organ transplantation.
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Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.
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Calcineurin Targets Involved in Stress Survival and Fungal Virulence.
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Calcineurin activation causes retinal ganglion cell degeneration.
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Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans.
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Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis.
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Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus.
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Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis.
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Calcineurin finds a new partner in the L-type Ca2+ channel.
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Calcineurin governs thermotolerance and virulence of Cryptococcus gattii.
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Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.
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Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
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Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T-regulatory cells.
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Calcineurin is essential for Candida albicans survival in serum and virulence.
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Calcineurin is essential for survival during membrane stress in Candida albicans.
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Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
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Calcineurin is required for Candida albicans to survive calcium stress in serum.
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Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.
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Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae.
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Calcineurin is required for virulence of Cryptococcus neoformans.
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Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development.
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Calcineurin mediates pancreatic growth in protease inhibitor-treated mice.
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Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
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Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.
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Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides.
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Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
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Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
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Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.
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Calcineurin signaling and muscle remodeling.
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Calcineurin signaling in human cardiac hypertrophy.
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Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.
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Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans.
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Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans.
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Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.
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Calcineurin-dependent galactomannan release in Aspergillus fumigatus.
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Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.
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Calcineurin. Structure, function, and inhibition.
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Calcineurin: a central controller of signalling in eukaryotes.
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Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.
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Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow.
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Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth.
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Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens.
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Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus.
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Calcium-dependent gene regulation in myocyte hypertrophy and remodeling.
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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.
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Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways.
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Cell biology. A fungal Achilles' heel.
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Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.
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Clinical trials: where are we now?
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Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae.
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Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.
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Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia.
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Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi.
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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.
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Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.
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Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus.
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Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem.
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Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans.
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Domain II of calmodulin is involved in activation of calcineurin.
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Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.
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Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene.
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Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.
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Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans.
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Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.
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Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
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FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
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Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.
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Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation.
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Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila.
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Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans.
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Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata.
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Good fungi gone bad: the corruption of calcineurin.
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Gq signaling causes glomerular injury by activating TRPC6.
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Gq-dependent signaling upregulates COX2 in glomerular podocytes.
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Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.
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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
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Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.
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Hypoxia reprograms calcium signaling and regulates myoglobin expression.
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Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.
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Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm.
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Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
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Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.
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In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates.
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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
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Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles.
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Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.
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Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.
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Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae.
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Lifetime cost-effectiveness of calcineurin inhibitor withdrawal after de novo renal transplantation.
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Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration.
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Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus.
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MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.
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Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.
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Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.
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Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
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Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.
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Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.
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Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae.
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Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.
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Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.
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Newer combination antifungal therapies for invasive aspergillosis.
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Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus.
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PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.
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Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans.
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Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus.
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Physiologic importance of protein phosphatase inhibitors.
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Potential Microbiological Effects of Higher Dosing of Echinocandins.
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Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.
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Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.
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Regulation of cell cycle progression by calcium/calmodulin-dependent pathways.
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Regulation of tumor necrosis factor cytotoxicity by calcineurin.
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Remodeling muscles with calcineurin.
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Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.
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Role of Ca++/calmodulin binding proteins in Aspergillus nidulans cell cycle regulation.
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Role of calcium in T-lymphocyte activation.
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Roles for Stress Response and Cell Wall Biosynthesis Pathways in Caspofungin Tolerance in Cryptococcus neoformans.
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Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.
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Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.
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Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.
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Selective activation and inhibition of calmodulin-dependent enzymes by a calmodulin-like protein found in human epithelial cells.
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Signal transduction cascades regulating fungal development and virulence.
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Signal-transduction cascades as targets for therapeutic intervention by natural products.
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Signaling cascades as drug targets in model and pathogenic fungi.
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Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures.
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Steering growth cones with a CaMKII/calcineurin switch.
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Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo.
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Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive.
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Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
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TRPC1 channels are critical for hypertrophic signaling in the heart.
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TRPC3 channels confer cellular memory of recent neuromuscular activity.
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Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function.
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Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
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Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
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The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans.
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The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function.
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The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
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The role of modulatory calcineurin-interacting proteins in calcineurin signaling.
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The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth.
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Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.
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Use of protein phosphatase inhibitors.
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Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study.
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vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.
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