Receptors, CXCR4
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Subject Areas on Research
- Abl kinases are required for invadopodia formation and chemokine-induced invasion.
- Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence.
- Agents under investigation for the treatment and prevention of neutropenia.
- CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
- CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.
- Chemokine (C-C motif) receptor 5-using envelopes predominate in dual/mixed-tropic HIV from the plasma of drug-naive individuals.
- Chemokine receptors and human immunodeficiency virus infection.
- Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophages.
- Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.
- Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.
- Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.
- Detection of HIV-1 neutralizing antibodies in a human CD4⁺/CXCR4⁺/CCR5⁺ T-lymphoblastoid cell assay system.
- Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
- Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone.
- Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity.
- Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.
- E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
- Effects of human immunodeficiency virus type 1 infection on CCR5 and CXCR4 coreceptor expression on CD4 T lymphocyte subsets in infants and adolescents.
- Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.
- Evidence that antibody-mediated neutralization of human immunodeficiency virus type 1 by sera from infected individuals is independent of coreceptor usage.
- Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.
- G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.
- Gene expression profiling of familial and sporadic interstitial pneumonia.
- Genotypic analysis of the V3 region of HIV from virologic nonresponders to maraviroc-containing regimens reveals distinct patterns of failure.
- HIV entry inhibitors: progress in development and application.
- HIV envelope gp120 activates human arterial smooth muscle cells.
- HIV. A clever hijacker of the immune system.
- In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.
- Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
- Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.
- Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization.
- Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism.
- Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment.
- Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.
- Molecular characterization of circulating plasma cells in patients with active systemic lupus erythematosus.
- Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women.
- Murine CXCR-4 is a functional coreceptor for T-cell-tropic and dual-tropic strains of human immunodeficiency virus type 1.
- Murine Glucocorticoid Receptors Orchestrate B Cell Migration Selectively between Bone Marrow and Blood.
- Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.
- Phylodynamics of HIV-1 in lymphoid and non-lymphoid tissues reveals a central role for the thymus in emergence of CXCR4-using quasispecies.
- Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis.
- Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.
- Primary isolate neutralization by HIV type 1-infected patient sera in the era of highly active antiretroviral therapy.
- Progenitor cell mobilization enhances bone healing by means of improved neovascularization and osteogenesis.
- Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization.
- Role of chemokine receptors in HIV-1 infection and pathogenesis.
- Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.
- Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis.
- Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.
- Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer.
- The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
- The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases.
- Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility.
- Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.
- Vein graft neointimal hyperplasia is exacerbated by CXCR4 signaling in vein graft-extrinsic cells.
- WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.
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Keywords of People
- McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Duke Innovation & Entrepreneurship