Chemokines, CXC

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  Subject Areas on Research

  • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. 
  • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. 
  • Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis. 
  • Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct. 
  • Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. 
  • Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung. 
  • Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. 
  • CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. 
  • CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. 
  • Chemokine receptor polymorphisms and GB virus C status in HIV-positive patients. 
  • Chemokines and B-cell homing to follicles. 
  • Chemokines and their receptors in human renal allotransplantation. 
  • Chronic ethanol intoxication enhances the production of cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein-2 by hepatocytes after human immunodeficiency virus-1 glycoprotein 120 vaccination. 
  • ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis. 
  • Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism. 
  • Elevation of CXCR3-binding chemokines in urine indicates acute renal-allograft dysfunction. 
  • Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. 
  • Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. 
  • Expression of three forms of melanoma growth stimulating activity (MGSA)/gro in human retinal pigment epithelial cells. 
  • Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. 
  • GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. 
  • Gene expression profiling of familial and sporadic interstitial pneumonia. 
  • Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection. 
  • HIV envelope gp120 activates human arterial smooth muscle cells. 
  • High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples. 
  • How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways. 
  • Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. 
  • Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow. 
  • Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. 
  • Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. 
  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. 
  • MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. 
  • Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes. 
  • Pharmacokinetics and tissue distribution of SB-251353, a novel human CXC chemokine, after intravenous administration to mice. 
  • Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. 
  • Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. 
  • Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization. 
  • Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. 
  • Role of hypoxia in inflammatory upper airway disease. 
  • Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis. 
  • Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. 
  • Should we B-leavin' now? 
  • Soluble CXCL16 and long-term outcome in acute ischemic stroke. 
  • Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos. 
  • Suppression of NF-kappaB-dependent proinflammatory gene expression in human RPE cells by a proteasome inhibitor. 
  • Surveillance of acute rejection in baboon renal transplantation by elevation of interferon-gamma inducible protein-10 and monokine induced by interferon-gamma in urine. 
  • The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha. 
  • The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. 
  • The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue. 
  • The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2. 
  • The chemokine SDF1 regulates migration of dentate granule cells. 
  • The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease. 
  • Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. 
  • Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Immunology