Sodium-Calcium Exchanger

• 

  Subject Areas on Research

  • A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. 
  • A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness. 
  • Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. 
  • Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture. 
  • Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study. 
  • Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line. 
  • Myocardial Na+/H+ exchanger-1 (NHE1) content is decreased by exercise training. 
  • Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. 
• 

  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute