Ryanodine Receptor Calcium Release Channel
-
Subject Areas on Research
-
A SNO storm in skeletal muscle.
-
Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart.
-
Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.
-
Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.
-
Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins.
-
Calcium Signaling and Cardiac Arrhythmias.
-
Calcium entry in skeletal muscle.
-
Calmodulin and CaMKII as molecular switches for cardiac ion channels.
-
Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor.
-
Classes of thiols that influence the activity of the skeletal muscle calcium release channel.
-
Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO.
-
De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies.
-
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
-
Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function.
-
Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
-
Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum.
-
Evidence for a junctional feet-ryanodine receptor complex from sarcoplasmic reticulum.
-
Excitation-contraction coupling in airway smooth muscle.
-
High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle.
-
Homer modulates NFAT-dependent signaling during muscle differentiation.
-
Hypoxia reprograms calcium signaling and regulates myoglobin expression.
-
Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.
-
Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals.
-
Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor).
-
Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.
-
Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel.
-
Non-sense mutations in the dihydropyridine receptor beta1 gene, CACNB1, paralyze zebrafish relaxed mutants.
-
Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.
-
Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor/Ca2+ release channel (RyR1): sites and nature of oxidative modification.
-
Physiology of nitric oxide in skeletal muscle.
-
Purification and reconstitution of the calcium release channel from skeletal muscle.
-
RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells.
-
Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstriction.
-
Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
-
Regulation of ryanodine receptors by reactive nitrogen species.
-
Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione.
-
Regulation of the skeletal muscle ryanodine receptor/Ca2+-release channel RyR1 by S-palmitoylation.
-
Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.
-
S-nitrosylation: spectrum and specificity.
-
Single-target molecule detection with nonbleaching multicolor optical immunolabels.
-
Skeletal muscle sarcoplasmic reticulum contains a NADH-dependent oxidase that generates superoxide.
-
Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.
-
Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex.
-
The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.
-
The human ryanodine receptor gene: its mapping to 19q13.1, placement in a chromosome 19 linkage group, and exclusion as the gene causing myotonic dystrophy.
-
The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions.
-
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
-
Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease.
-
Keywords of People
-
Bennett, Vann,
George B. Geller Professor for Research in Molecular Biology in the School of Medicine,
Duke Cancer Institute
-
Erickson, Harold Paul,
James B. Duke Professor of Cell Biology,
Biomedical Engineering
-
Landstrom, Andrew Paul,
Assistant Professor of Pediatrics,
Cell Biology
-
Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology