Ryanodine Receptor Calcium Release Channel
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Subject Areas on Research
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A SNO storm in skeletal muscle.
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Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart.
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Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation.
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Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.
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Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins.
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Calcium Signaling and Cardiac Arrhythmias.
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Calcium entry in skeletal muscle.
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Calmodulin and CaMKII as molecular switches for cardiac ion channels.
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Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor.
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Classes of thiols that influence the activity of the skeletal muscle calcium release channel.
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Cysteine-3635 is responsible for skeletal muscle ryanodine receptor modulation by NO.
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De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies.
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Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
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Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function.
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Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
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Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum.
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Evidence for a junctional feet-ryanodine receptor complex from sarcoplasmic reticulum.
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Excitation-contraction coupling in airway smooth muscle.
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High-affinity [3H]PN200-110 and [3H]ryanodine binding to rabbit and frog skeletal muscle.
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Homer modulates NFAT-dependent signaling during muscle differentiation.
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Hypoxia reprograms calcium signaling and regulates myoglobin expression.
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Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.
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Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals.
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Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor).
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Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
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Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.
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Nitric oxide, NOC-12, and S-nitrosoglutathione modulate the skeletal muscle calcium release channel/ryanodine receptor by different mechanisms. An allosteric function for O2 in S-nitrosylation of the channel.
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Non-sense mutations in the dihydropyridine receptor beta1 gene, CACNB1, paralyze zebrafish relaxed mutants.
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Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.
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Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor/Ca2+ release channel (RyR1): sites and nature of oxidative modification.
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Physiology of nitric oxide in skeletal muscle.
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Purification and reconstitution of the calcium release channel from skeletal muscle.
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RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells.
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Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstriction.
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Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
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Regulation of ryanodine receptors by reactive nitrogen species.
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Regulation of the cardiac muscle ryanodine receptor by O(2) tension and S-nitrosoglutathione.
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Regulation of the skeletal muscle ryanodine receptor/Ca2+-release channel RyR1 by S-palmitoylation.
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Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.
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S-nitrosylation: spectrum and specificity.
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Single-target molecule detection with nonbleaching multicolor optical immunolabels.
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Skeletal muscle sarcoplasmic reticulum contains a NADH-dependent oxidase that generates superoxide.
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Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.
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Structural and functional characterization of the purified cardiac ryanodine receptor-Ca2+ release channel complex.
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The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.
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The human ryanodine receptor gene: its mapping to 19q13.1, placement in a chromosome 19 linkage group, and exclusion as the gene causing myotonic dystrophy.
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The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions.
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Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
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Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease.
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Keywords of People
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Bennett, Vann,
George B. Geller Distinguished Professor for Research in Molecular Biology in the School of Medicine,
Duke Cancer Institute
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Erickson, Harold Paul,
James B. Duke Distinguished Professor of Cell Biology,
Biomedical Engineering
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Landstrom, Andrew Paul,
Assistant Professor of Pediatrics,
Cell Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology