Diacylglycerol Kinase

• 

  Subject Areas on Research

  • A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs. 
  • A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Cytogenetic assignment and physical mapping of the human DGKE gene to chromosome 17q22. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Diacylglycerol kinases in immune cell function and self-tolerance. 
  • Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. 
  • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. 
  • Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. 
  • FoxO-dependent regulation of diacylglycerol kinase α gene expression. 
  • Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice. 
  • Identification of a novel locus on 2q for autosomal dominant high-grade myopia. 
  • Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. 
  • MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ. 
  • Modulation of inositol phospholipid metabolism by polyamines. 
  • Myotonic muscular dystrophy. Calcium-dependent phosphatidate metabolism in the erythrocyte membrane. 
  • Negative regulation of mTOR activation by diacylglycerol kinases. 
  • Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. 
  • Receptor signaling in immune cell development and function. 
  • Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta. 
  • Role of diacylglycerol kinases in T cell development and function. 
  • SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. 
  • Suppression of diacylglycerol levels by antibodies reactive with the c-erbB-2 (HER-2/neu) gene product p185c-erbB-2 in breast and ovarian cancer cell lines. 
  • Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. 
  • Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta. 
  • T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha. 
  • Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. 
  • The role and regulation of mTOR in T-lymphocyte function. 
  • The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy. 
  • The role of diacylglycerol kinases in T cell anergy. 
  • Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development. 
  • Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology