Diacylglycerol Kinase
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Subject Areas on Research
- A geometric arrangement algorithm for structure determination of symmetric protein homo-oligomers from NOEs and RDCs.
- A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers.
- Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism.
- Cytogenetic assignment and physical mapping of the human DGKE gene to chromosome 17q22.
- DGK α and ζ Activities Control TH1 and TH17 Cell Differentiation.
- Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells.
- Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.
- Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
- Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity.
- Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
- Diacylglycerol kinases in immune cell function and self-tolerance.
- Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.
- Disruption of diacylglycerol metabolism impairs the induction of T cell anergy.
- Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
- FoxO-dependent regulation of diacylglycerol kinase α gene expression.
- Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice.
- Identification of a novel locus on 2q for autosomal dominant high-grade myopia.
- Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells.
- MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ.
- Modulation of inositol phospholipid metabolism by polyamines.
- Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice.
- Negative regulation of mTOR activation by diacylglycerol kinases.
- Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.
- Receptor signaling in immune cell development and function.
- Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.
- Role of diacylglycerol kinases in T cell development and function.
- SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.
- Suppression of diacylglycerol levels by antibodies reactive with the c-erbB-2 (HER-2/neu) gene product p185c-erbB-2 in breast and ovarian cancer cell lines.
- Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance.
- Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.
- Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.
- The role and regulation of mTOR in T-lymphocyte function.
- The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of rapamycin (mTOR) signaling and skeletal muscle hypertrophy.
- The role of diacylglycerol kinases in T cell anergy.
- Tight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development.
- Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8+ T cell differentiation.
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Keywords of People
- Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
- Zhong, Xiaoping, Professor of Pediatrics, Immunology