Chondrocytes

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  Subject Areas on Research

  • A biomechanical role for perlecan in the pericellular matrix of articular cartilage. 
  • A paper by Jones et al. Alterations in the Young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage (Journal of Biomechanics 32, 1999, 119-127). 
  • A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. 
  • A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. 
  • ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films. 
  • Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation. 
  • Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee. 
  • Adipose-derived adult stem cells for cartilage tissue engineering. 
  • Adjacent tissues (cartilage, bone) affect the functional integration of engineered calf cartilage in vitro. 
  • Alterations in the Young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. 
  • An allogenic cell-based implant for meniscal lesions. 
  • Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. 
  • Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes. 
  • Axin2 regulates chondrocyte maturation and axial skeletal development. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. 
  • Biomarkers and proteomic analysis of osteoarthritis. 
  • CCN1 Regulates Chondrocyte Maturation and Cartilage Development. 
  • CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues. 
  • Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture. 
  • Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture. 
  • Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. 
  • Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. 
  • Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. 
  • Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair. 
  • Chondral Lesions of the Knee: An Evidence-Based Approach. 
  • Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2. 
  • Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. 
  • Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. 
  • Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. 
  • Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. 
  • Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. 
  • Cocultures of adult and juvenile chondrocytes compared with adult and juvenile chondral fragments: in vitro matrix production. 
  • Composition and transport properties of human ankle and knee cartilage. 
  • DIO2 modifies inflammatory responses in chondrocytes. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Design and characterization of poly(ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchymal stem cells. 
  • Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. 
  • Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro. 
  • Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. 
  • ECM production of primary human and bovine chondrocytes in hybrid PEG hydrogels containing type I collagen and hyaluronic acid. 
  • EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. 
  • Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds. 
  • Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers. 
  • Elucidating the Molecular Composition of Cartilage by Proteomics. 
  • Engineering superficial zone features in tissue engineered cartilage. 
  • Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine. 
  • Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc. 
  • Fluorescent viability stains overestimate chondrocyte viability in osteoarticular allografts. 
  • Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. 
  • Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. 
  • Generation of articular chondrocytes from human pluripotent stem cells. 
  • Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. 
  • Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. 
  • HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. 
  • Healing potential of transplanted allogeneic chondrocytes of three different sources in lesions of the avascular zone of the meniscus: a pilot study. 
  • Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. 
  • Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development. 
  • Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. 
  • In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells. 
  • Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. 
  • Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. 
  • Influence of oxygen tension on interleukin 1-induced peroxynitrite formation and matrix turnover in articular cartilage. 
  • Influence of physical properties of biomaterials on cellular behavior. 
  • Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering. 
  • Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner. 
  • Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. 
  • Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma. 
  • Isolated chondrons: a viable alternative for studies of chondrocyte metabolism in vitro. 
  • Isolation and Culture of Murine Primary Chondrocytes: Costal and Growth Plate Cartilage. 
  • Isolation and culture of murine primary chondrocytes. 
  • Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu. 
  • Large fresh osteochondral allografts of the knee: a systematic clinical and basic science review of the literature. 
  • Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. 
  • Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine-glycine-aspartate concentration gradient hydrogels. 
  • Mechanobiology of the meniscus. 
  • Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Morphology and physiology of the epiphyseal growth plate. 
  • Mutant IDH is sufficient to initiate enchondromatosis in mice. 
  • Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation. 
  • NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. 
  • Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. 
  • Nitric oxide--friend or foe in arthritis? 
  • Nonlinear osmotic properties of the cell nucleus. 
  • Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. 
  • Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. 
  • Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells. 
  • Osteochondral autologous transfer system. 
  • Osteochondral lesions: medial versus lateral, persistent pain, cartilage restoration options and indications. 
  • PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. 
  • PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. 
  • PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. 
  • Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. 
  • Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. 
  • Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression. 
  • Preparation techniques for the injection of human autologous cartilage: an ex vivo feasibility study. 
  • Primary cilia attenuate hedgehog signalling in neoplastic chondrocytes. 
  • Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient. 
  • Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter. 
  • Quantitative phase microscopy of articular chondrocyte dynamics by wide-field digital interferometry. 
  • RNA extraction from human articular cartilage by chondrocyte isolation. 
  • Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis. 
  • Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage. 
  • Regulation of chondrocytic gene expression by biomechanical signals. 
  • Repair response of the inner and outer regions of the porcine meniscus in vitro. 
  • Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production. 
  • Role of Piezo Channels in Joint Health and Injury. 
  • Role of pericellular matrix in development of a mechanically functional neocartilage. 
  • Scaffold-Based Therapies: Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. 
  • Selenomethionine exposure affects chondrogenic differentiation and bone formation in Japanese medaka (Oryzias latipes). 
  • Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes. 
  • Sequential roles of Hedgehog and Wnt signaling in osteoblast development. 
  • Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes. 
  • Skeletal dysplasias and the growth plate. 
  • Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. 
  • Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair. 
  • Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. 
  • Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. 
  • Specification of chondrocytes and cartilage tissues from embryonic stem cells. 
  • Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. 
  • Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate. 
  • Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. 
  • Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. 
  • TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. 
  • TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. 
  • TCDD disrupts hypural skeletogenesis during medaka embryonic development. 
  • TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. 
  • TSG-6 - a double-edged sword for osteoarthritis (OA). 
  • Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. 
  • Targets to tackle--the pathophysiology of the disease. 
  • Tenascin-C expression and distribution in cultured human chondrocytes and chondrosarcoma cells. 
  • Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. 
  • The development of posttraumatic arthritis after articular fracture. 
  • The effect of dynamic mechanical compression on nitric oxide production in the meniscus. 
  • The effect of irrigation solution at different temperatures on articular cartilage metabolism. 
  • The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. 
  • The incidence of enlarged chondrons in normal and osteoarthritic human cartilage and their relative matrix density. 
  • The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. 
  • The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. 
  • The role of cytokines in posttraumatic arthritis. 
  • Tissue engineering for meniscus repair. 
  • Topical Review: MACI as an Emerging Technology for the Treatment of Talar Osteochondral Lesions. 
  • Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. 
  • Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. 
  • Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. 
  • Viability and apoptosis of human chondrocytes in osteochondral fragments following joint trauma. 
  • Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes. 
  • Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy. 
  • Why Do Osteochondral Allografts Survive? Comparative Analysis of Cartilage Biochemical Properties Unveils a Molecular Basis for Durability. 
  • Will we be able to repair osteoarthritic joints? New drugs and surgical techniques for cartilage problems. 
  • Zonal changes in the three-dimensional morphology of the chondron under compression: The relationship among cellular, pericellular, and extracellular deformation in articular cartilage 
  • [Diagnosis and treatment of osteochondral lesions of the talus]. 
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  Keywords of People

  • Cohen, Seth Morris, Professor of Head and Neck Surgery & Communication Sciences, Head and Neck Surgery & Communication Sciences
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Hilton, Matthew James, Associate Professor in Orthopaedic Surgery, Cell Biology