Nuclear Localization Signals

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  Subject Areas on Research

  • Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation. 
  • Determination of the functional domain organization of the importin alpha nuclear import factor. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Early recruitment of AU-rich element-containing mRNAs determines their cytosolic fate during iron deficiency. 
  • Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport. 
  • Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. 
  • Identification of the TBX5 transactivating domain and the nuclear localization signal. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Light-Dependent Cytoplasmic Recruitment Enhances the Dynamic Range of a Nuclear Import Photoswitch. 
  • Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses. 
  • Nonsense mediated decay induced by tethered human UPF3B is restricted to the cytoplasm. 
  • Nuclear localization of NPR1 is required for activation of PR gene expression. 
  • Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. 
  • Radioiodinated O(6)-Benzylguanine derivatives containing an azido function. 
  • Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy. 
  • Targeting to transcriptionally active loci by the hydrophilic N-terminal domain of Drosophila DNA topoisomerase I. 
  • The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. 
  • The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function. 
  • The human tap nuclear RNA export factor contains a novel transportin-dependent nuclear localization signal that lacks nuclear export signal function.