Cyclin E
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Subject Areas on Research
- Addition of rituximab to chemotherapy overcomes the negative prognostic impact of cyclin E expression in diffuse large B-cell lymphoma.
- Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.
- Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
- Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
- Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup.
- Cyclin E overexpression relates to ovarian cancer histology but not to risk factors.
- Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control.
- Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation.
- E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
- Error-prone polyploid mitosis during normal Drosophila development.
- Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis.
- Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma.
- Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.
- N-myc regulates parkin expression.
- Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways.
- Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.
- P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.
- PIN1, the cell cycle and cancer.
- Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium.
- Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
- The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.
- Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.
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Keywords of People
- Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
- Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute