Cyclin E

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  Subject Areas on Research

  • Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. 
  • Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. 
  • Cyclin E overexpression in epithelial ovarian cancer characterizes an etiologic subgroup. 
  • Cyclin E overexpression relates to ovarian cancer histology but not to risk factors. 
  • Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. 
  • Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation. 
  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. 
  • N-myc regulates parkin expression. 
  • Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. 
  • Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. 
  • Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. 
  • P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. 
  • PIN1, the cell cycle and cancer. 
  • Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium. 
  • Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. 
  • The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. 
  • Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Moorman, Patricia Gripka, Professor in Family Medicine and Community Health, Duke Cancer Institute