Cyclin D1

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  Subject Areas on Research

  • A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. 
  • A network of genetic events sufficient to convert normal human cells to a tumorigenic state. 
  • AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells. 
  • Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia. 
  • Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma. 
  • Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast. 
  • Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium. 
  • All-trans-retinoic acid mediates G1 arrest but not apoptosis of normal human mammary epithelial cells. 
  • Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. 
  • Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia. 
  • Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway. 
  • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. 
  • BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. 
  • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 
  • Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts. 
  • Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. 
  • Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity. 
  • Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma. 
  • Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. 
  • Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions. 
  • Complex response of breast epithelial cell lines to topoisomerase inhibitors. 
  • Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Cyclin D-1, interleukin-6, HER-2/neu, transforming growth factor receptor-II and prediction of relapse in women with early stage, hormone receptor-positive breast cancer treated with tamoxifen. 
  • Cyclin D1 G870A polymorphism and breast cancer risk: a meta-analysis comprising 9,911 cases and 11,171 controls. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cyclin D1 polymorphism and increased risk of colorectal cancer at young age. 
  • Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study. 
  • Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. 
  • Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression. 
  • Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest. 
  • Dysregulated expression of cyclin D1 in normal human mammary epithelial cells inhibits all-trans-retinoic acid-mediated G0/G1-phase arrest and differentiation in vitro. 
  • Effects of curcumin in an orthotopic murine bladder tumor model. 
  • Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation. 
  • Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer. 
  • Erythrophagocytosis in a cyclin D1 positive plasma cell myeloma with near-tetraploid karyotypic abnormalities and cryptic MYC/IGH fusion. 
  • First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 
  • Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. 
  • Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours. 
  • Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV. 
  • Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene. 
  • Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation. 
  • Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. 
  • Interaction of MUC1 with beta-catenin modulates the Wnt target gene cyclinD1 in H. pylori-induced gastric cancer. 
  • Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. 
  • Mantle Cell Lymphoma With Mantle Zone Growth Pattern. 
  • Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. 
  • Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor. 
  • Over-expression of cyclin D1 regulates Cdk4 protein synthesis. 
  • Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer. 
  • P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively. 
  • Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study. 
  • Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. 
  • Prevalence and clinical implications of cyclin D1 expression in diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program. 
  • Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. 
  • Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition. 
  • Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expression. 
  • Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis. 
  • SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. 
  • Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. 
  • The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. 
  • The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. 
  • Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells. 
  • p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma. 
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  Keywords of People

  • Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology