Cyclin D1
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Subject Areas on Research
- A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
- A network of genetic events sufficient to convert normal human cells to a tumorigenic state.
- AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells.
- Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia.
- Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma.
- Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast.
- Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium.
- All-trans-retinoic acid mediates G1 arrest but not apoptosis of normal human mammary epithelial cells.
- Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia.
- Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway.
- Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.
- BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.
- CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.
- Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
- Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
- Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity.
- Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma.
- Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications.
- Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions.
- Complex response of breast epithelial cell lines to topoisomerase inhibitors.
- Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes.
- Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
- Cyclin D1 G870A polymorphism and breast cancer risk: a meta-analysis comprising 9,911 cases and 11,171 controls.
- Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment.
- Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.
- Cyclin D1 polymorphism and increased risk of colorectal cancer at young age.
- Cyclin D1 polymorphism and risk for squamous cell carcinoma of the head and neck: a case-control study.
- Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.
- Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression.
- Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest.
- Dysregulated expression of cyclin D1 in normal human mammary epithelial cells inhibits all-trans-retinoic acid-mediated G0/G1-phase arrest and differentiation in vitro.
- Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer.
- Erythrophagocytosis in a cyclin D1 positive plasma cell myeloma with near-tetraploid karyotypic abnormalities and cryptic MYC/IGH fusion.
- First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
- Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library.
- Glutathione S-transferase GSTP1 and cyclin D1 genotypes: association with numbers of basal cell carcinomas in a patient subgroup at high-risk of multiple tumours.
- Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV.
- Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.
- Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
- Interaction of MUC1 with beta-catenin modulates the Wnt target gene cyclinD1 in H. pylori-induced gastric cancer.
- Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1.
- Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas.
- Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines.
- Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor.
- Over-expression of cyclin D1 regulates Cdk4 protein synthesis.
- Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer.
- P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.
- Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study.
- Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies.
- Prevalence and clinical implications of cyclin D1 expression in diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program.
- Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.
- Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition.
- Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expression.
- Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis.
- SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.
- Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.
- The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
- The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.
- Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells.
- p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
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Keywords of People
- Linardic, Corinne Mary, Associate Professor of Pediatrics, Pharmacology & Cancer Biology