Cyclin-Dependent Kinase Inhibitor p16
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Subject Areas on Research
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A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.
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A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas.
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A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.
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AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells.
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Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia.
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Aberrant expression of tumor suppressor proteins in the Ewing family of tumors.
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Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
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Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast.
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Abrogation of the RB-p16 tumor suppressor pathway in human lung cancer.
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Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
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Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma.
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Aneuploidy of chromosome 9 and the tumor suppressor genes p16(INK4) and p15(INK4B) detected by in situ hybridization in locally advanced prostate cancer.
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Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers.
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Association of human papilloma virus status and response to radiotherapy in vulvar squamous cell carcinoma.
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Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study.
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Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians.
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Biology of small cell lung cancer.
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CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.
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CDKN2 in HPV-positive and HPV-negative cervical-carcinoma cell lines.
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CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.
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CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables.
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CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.
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Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
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Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions.
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Consortium analysis of 7 candidate SNPs for ovarian cancer.
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Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers.
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Correspondence re: Geradts J, Wilentz RE, Roberts H. Immunohistochemical detection of the alternate ink4a-encoded tumor suppressor protein p14(arf) in archival human cancers and cell lines using commercial antibodies: correlation with p16(ink4a) expression. Mod pathol 2001;14:1162-68.
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DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.
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Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.
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Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma.
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Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate.
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Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells.
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Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancer.
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Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines.
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Dynamic behavioural interpretation of cervical intraepithelial neoplasia with molecular biomarkers.
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E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites.
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Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors.
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Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.
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Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression.
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Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues.
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Gene expression profiling and genetic markers in glioblastoma survival.
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Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.
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Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma.
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Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.
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Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.
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Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.
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High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma.
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High frequency of aberrant p16(INK4A) expression in human breast cancer.
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High motility group overexpression accelerates T-cell leukemogenesis.
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Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.
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Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.
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INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
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Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma.
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Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
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Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression.
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Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies.
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Improved grading of IDH-mutated astrocytic gliomas.
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In vivo and in vitro propagation of intraductal papillary mucinous neoplasms.
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Increased expression of senescence markers in cystic fibrosis airways.
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Induction of CD56 and TCR-independent activation of T cells with aging.
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Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome.
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Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation.
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Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomas.
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Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian cancers lacking p53 mutations.
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Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas.
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Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach.
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Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas.
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Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage.
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Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
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Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.
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Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression.
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Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors.
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Molecular characterization of adenocarcinoma of the cervix.
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Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors.
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Morphologic and molecular genetic aspects of oligodendroglial neoplasms.
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Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.
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Mutational profiles of head and neck squamous cell carcinomas based upon human papillomavirus status in the Veterans Affairs National Precision Oncology Program.
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Mutations of the p16 gene product are rare in prostate cancer.
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NMR structural characterization of the CDK inhibitor p19INK4d.
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Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product.
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Novel human bronchial epithelial cell lines for cystic fibrosis research.
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Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.
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Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing.
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PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.
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Performance of p16INK4a ELISA as a primary cervical cancer screening test among a large cohort of HIV-infected women in western Kenya: a 2-year cross-sectional study.
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Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation.
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Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.
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Rb and p16INK4a expression in resected non-small cell lung tumors.
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Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression.
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Replicative senescence revisited.
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Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904.
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So-called massive retinal gliosis: A critical review and reappraisal.
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Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
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TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice.
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Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
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The LAST guidelines in clinical practice: implementing recommendations for p16 use.
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The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.
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The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.
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The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4.
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The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.
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Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.
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Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site.
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Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
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c-Jun promotes whereas JunB inhibits epidermal neoplasia.
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mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Moorman, Patricia Gripka,
Professor Emeritus in Family Medicine and Community Health,
Duke Cancer Institute