-
Subject Areas on Research
-
A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.
-
A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation.
-
A cardiac arrhythmia syndrome caused by loss of ankyrin-B function.
-
A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.
-
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
-
A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway.
-
A gain-of-function polymorphism controlling complex traits and fitness in nature.
-
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
-
A kinesin motor in a force-producing conformation.
-
A mutant of the motor protein kinesin that moves in both directions on microtubules.
-
A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.
-
A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides.
-
A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
-
A novel relaxase homologue is involved in chromosomal DNA processing for type IV secretion in Neisseria gonorrhoeae.
-
A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides.
-
A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.
-
A structural pathway for activation of the kinesin motor ATPase.
-
A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein.
-
A unique type II topoisomerase mutant that is hypersensitive to a broad range of cleavage-inducing antitumor agents.
-
APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
-
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
-
Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
-
Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.
-
Accelerated decline in lung function in cigarette smokers is associated with TP53/HDM2 polymorphisms.
-
Allelic and locus heterogeneity in inherited venous malformations.
-
Altered light responses of single rod photoreceptors in transgenic pigs expressing P347L or P347S rhodopsin.
-
Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.
-
Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality.
-
Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants.
-
An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides.
-
An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
-
Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
-
Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes.
-
Analysis of partial pol and env sequences indicates a high prevalence of HIV type 1 recombinant strains circulating in Gabon.
-
Analysis of the action of lidocaine on insect sodium channels.
-
Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.
-
Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency.
-
Assessment of small in-frame indels and C-terminal nonsense variants of BRCA1 using a validated functional assay.
-
Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches.
-
Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population.
-
Autosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3.
-
Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.
-
BDNF Val66Met genotype and 6-month remission rates in late-life depression.
-
Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
-
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).
-
Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.
-
Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells.
-
Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.
-
Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks.
-
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
-
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis.
-
CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.
-
Ca2+-sensitive inactivation and facilitation of L-type Ca2+ channels both depend on specific amino acid residues in a consensus calmodulin-binding motif in the(alpha)1C subunit.
-
Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.
-
Cardioprotective role of S-nitrosylated hemoglobin from rbc.
-
Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.
-
Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.
-
Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast.
-
Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations.
-
Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
-
Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity.
-
Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant.
-
Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage.
-
Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.
-
Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes.
-
Confirmation of the involvement of protein domain movement during the catalytic cycle of the cytochrome bc1 complex by the formation of an intersubunit disulfide bond between cytochrome b and the iron-sulfur protein.
-
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus.
-
Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.
-
Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.
-
Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition.
-
Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.
-
Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel.
-
Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
-
Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly.
-
Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses.
-
De novo variants in the alternative exon 5 of SCN8A cause epileptic encephalopathy.
-
Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing.
-
Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia.
-
Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis.
-
Definition of a consensus transportin-specific nucleocytoplasmic transport signal.
-
Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.
-
Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks).
-
Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control.
-
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup.
-
Different structural changes occur in blue- and green-proteorhodopsins during the primary photoreaction.
-
Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
-
Dissecting the order of bacteriophage T4 DNA polymerase holoenzyme assembly.
-
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
-
Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis.
-
Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs).
-
Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency.
-
Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.
-
Drug-associated changes in amino acid residues in Gag p2, p7(NC), and p6(Gag)/p6(Pol) in human immunodeficiency virus type 1 (HIV-1) display a dominant effect on replicative fitness and drug response.
-
EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis.
-
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
-
Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner.
-
Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.
-
Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis.
-
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes.
-
Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels.
-
Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression.
-
Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection.
-
Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.
-
FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG).
-
Facile chemical synthesis and equilibrium unfolding properties of CopG.
-
Factor VIII Arg2304 --> His binds to phosphatidylserine and is a functional cofactor in the factor X-ase complex.
-
Fast and faster: a designed variant of the B-domain of protein A folds in 3 microsec.
-
Fibrinogen binding is affected by amino acid substitutions in C-terminal repeat region of fibronectin binding protein A.
-
Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.
-
Folding kinetics of a fluorescent variant of monomeric lambda repressor.
-
Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins.
-
FtsZ filament dynamics at steady state: subunit exchange with and without nucleotide hydrolysis.
-
Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling.
-
Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations.
-
Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene.
-
Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia.
-
Functional domain organization of human APOBEC3G.
-
Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia.
-
Functional evolution of an anthocyanin pathway enzyme during a flower color transition.
-
G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t.
-
Ganglioside-induced differentiation-associated protein-1 is mutant in Charcot-Marie-Tooth disease type 4A/8q21.
-
Gene expression levels influence amino acid usage and evolutionary rates in endosymbiotic bacteria.
-
Genetic association between endothelial nitric oxide synthase and Alzheimer disease.
-
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
-
Genetic convergence of rare lymphomas.
-
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.
-
Genetic polymorphisms: a cornerstone of translational biobehavioral research.
-
Genetic testing improves identification of transthyretin amyloid (ATTR) subtype in cardiac amyloidosis.
-
Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects.
-
Genome wide analyses reveal little evidence for adaptive evolution in many plant species.
-
Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank.
-
Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.
-
Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase.
-
Glutaric acidemia type 1 in patients of Lumbee heritage from North Carolina.
-
HDAC6 modulates cell motility by altering the acetylation level of cortactin.
-
HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG).
-
High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation.
-
Histone deacetylase 6 (HDAC6) promotes the pro-survival activity of 14-3-3ζ via deacetylation of lysines within the 14-3-3ζ binding pocket.
-
How can a single second sphere amino acid substitution cause reduction midpoint potential changes of hundreds of millivolts?
-
Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.
-
Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients.
-
Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag.
-
Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9.
-
Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.
-
Identification and functional study of a mild allele of SlDELLA gene conferring the potential for improved yield in tomato.
-
Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization.
-
Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel.
-
Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits.
-
Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.
-
Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.
-
Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120.
-
Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.
-
Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels.
-
Identification of two novel mutations in families with X-linked ocular albinism.
-
Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus.
-
Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight.
-
Impact of amino acid substitutions at secondary structures in the BRCT domains of the tumor suppressor BRCA1: Implications for clinical annotation.
-
Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.
-
Importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators.
-
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
-
Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.
-
Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.
-
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
-
Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.
-
Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis.
-
Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY.
-
Juvenile bilateral lens dislocation and glaucoma associated with a novel mutation in the fibrillin 1 gene.
-
Kinetic role of helix caps in protein folding is context-dependent.
-
Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.
-
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
-
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.
-
Late onset N-acetylglutamate synthase deficiency caused by hypomorphic alleles.
-
Lefty proteins exhibit unique processing and activate the MAPK pathway.
-
Ligand concentration regulates the pathways of coupled protein folding and binding.
-
Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture.
-
Localization and structure of the ankyrin-binding site on beta2-spectrin.
-
Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization.
-
Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.
-
Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites.
-
Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes.
-
Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump.
-
Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.
-
Missense mutation in a von Willebrand factor type A domain of the alpha 3(VI) collagen gene (COL6A3) in a family with Bethlem myopathy.
-
Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.
-
Molecular and clinical analysis of ALPL in a cohort of patients with suspicion of Hypophosphatasia.
-
Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C.
-
Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole.
-
Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti.
-
Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus.
-
Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP.
-
Multiple Surface Regions on the Niemann-Pick C2 Protein Facilitate Intracellular Cholesterol Transport.
-
Mutant IDH is sufficient to initiate enchondromatosis in mice.
-
Mutation and polymorphism analysis in the tuberous sclerosis 2 (TSC2) gene.
-
Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats.
-
Mutational analysis of ATP7B and genotype-phenotype correlation in Japanese with Wilson's disease.
-
Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.
-
Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA.
-
Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion.
-
Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the β3-β4 loop to favor a low-affinity drug-binding state.
-
Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit.
-
N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.
-
Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.
-
Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea.
-
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
-
No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma.
-
Non-lethal congenital hypotonia due to glycogen storage disease type IV.
-
Nonfunctional Missense Mutants in Two Well Characterized Cytosolic Enzymes Reveal Important Information About Protein Structure and Function.
-
Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.
-
Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation.
-
Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data.
-
Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).
-
Phosphorylation of DHBV pre-S: identification of the major site of phosphorylation and effects of mutations on the virus life cycle.
-
Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
-
Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
-
Point mutations alter the mechanical stability of immunoglobulin modules.
-
Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.
-
Polymorphisms in fibronectin binding protein A of Staphylococcus aureus are associated with infection of cardiovascular devices.
-
Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis.
-
Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.
-
Predictable patterns of constraint among anthocyanin-regulating transcription factors in Ipomoea.
-
Predominantly buried residues in the response regulator Spo0F influence specific sensor kinase recognition.
-
Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma.
-
Primary infection by a human immunodeficiency virus with atypical coreceptor tropism.
-
Probing structure-function relationships in missense variants in the carboxy-terminal region of BRCA1.
-
Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage.
-
Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution.
-
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.
-
Protein dynamic studies move to a new time slot.
-
Quaternary epitope specificities of anti-HIV-1 neutralizing antibodies generated in rhesus macaques infected by the simian/human immunodeficiency virus SHIVSF162P4.
-
RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
-
Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
-
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
-
Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers.
-
Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections.
-
Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding.
-
Relaxed constraint and evolutionary rate variation between basic helix-loop-helix floral anthocyanin regulators in Ipomoea.
-
Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses.
-
Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
-
Residues of heat-labile enterotoxin involved in bacterial cell surface binding.
-
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase.
-
Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome.
-
Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development.
-
Retinitis pigmentosa associated with rhodopsin mutations: Correlation between phenotypic variability and molecular effects.
-
RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
-
Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding.
-
Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.
-
Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation.
-
Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress.
-
Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency.
-
Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.
-
Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase.
-
Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae.
-
Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin.
-
Selection of novel affinity-matured human chondroitin sulfate proteoglycan 4 antibody fragments by yeast display.
-
Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes.
-
Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.
-
Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle.
-
Site-specific polyubiquitination differentially regulates parathyroid hormone receptor-initiated MAPK signaling and cell proliferation.
-
Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe.
-
Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity.
-
Spontaneous Differentiation of T Follicular Helper Cells in LATY136F Mutant Mice.
-
Structural basis for μ-opioid receptor binding and activation.
-
Structural changes in the photoactive site of proteorhodopsin during the primary photoreaction.
-
Structural studies and protein engineering of inositol phosphate multikinase.
-
Structure and function of the glycosaminoglycan binding site of chemokine macrophage-inflammatory protein-1 beta.
-
Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion.
-
Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.
-
Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin.
-
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
-
Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.
-
Systemic interleukin-2 and adoptive transfer of lymphokine-activated killer cells improves antibody-dependent cellular cytotoxicity in patients with relapsed B-cell lymphoma treated with rituximab.
-
T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families.
-
TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death.
-
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.
-
TSPEAR variants are primarily associated with ectodermal dysplasia and tooth agenesis but not hearing loss: A novel cohort study.
-
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
-
The G185R mutation disrupts function of the iron transporter Nramp2.
-
The HOXB13 variant X285K is associated with clinical significance and early age at diagnosis in African American prostate cancer patients.
-
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
-
The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction.
-
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
-
The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog.
-
The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency.
-
The brain-derived neurotrophic factor VAL66MET polymorphism and cerebral white matter hyperintensities in late-life depression.
-
The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
-
The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β1-adrenergic receptor expression and signaling.
-
The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.
-
The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study.
-
The extra fragment of the iron-sulfur protein (residues 96-107) of Rhodobacter sphaeroides cytochrome bc1 complex is required for protein stability.
-
The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains.
-
The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
-
The nucleolar localization domain of the catalytic subunit of human telomerase.
-
The phage T4 protein UvsW drives Holliday junction branch migration.
-
The structure of PurR mutant L54M shows an alternative route to DNA kinking.
-
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
-
Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe.
-
Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit.
-
Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling.
-
Tuning magnesium sensitivity of BK channels by mutations.
-
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.
-
Two-state displacement by the kinesin-14 Ncd stalk.
-
Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants.
-
Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1).
-
Using viral species specificity to define a critical protein/RNA interaction surface.
-
VSV transmembrane domain (TMD) peptide promotes PEG-mediated fusion of liposomes in a conformationally sensitive fashion.
-
Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.
-
Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.
-
WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.
-
d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution.
-
epitopes immediately below the base of the V3 loop of gp120 as targets for the initial autologous neutralizing antibody response in two HIV-1 subtype B-infected individuals.
-
p53-dependent induction of heat shock protein 27 (HSP27) expression.
-
p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature.
-
μ-Opioid receptor gene A118G polymorphism predicts survival in patients with breast cancer.
-
Keywords of People
-
Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
-
Ferrari, Guido,
Professor in Surgery,
Molecular Genetics and Microbiology
-
Liu, Yutao,
Adjunct Assistant Professor in the Department of Medicine,
Medicine, Medical Genetics
-
Moorman, Patricia Gripka,
Professor Emeritus in Family Medicine and Community Health,
Duke Cancer Institute
-
Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
-
Starmer, Charles Franklin,
Professor Emeritus of Computer Science,
Computer Science