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Subject Areas on Research
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2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.
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A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice.
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A TRPA1-dependent mechanism for the pungent sensation of weak acids.
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A bird's eye view: top down intracellular analyses of auditory selectivity for learned vocalizations.
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A cardiac arrhythmia syndrome caused by loss of ankyrin-B function.
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A method to measure myocardial calcium handling in adult Drosophila.
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A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.
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A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.
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A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling.
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A sharp-edge-based acoustofluidic chemical signal generator.
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ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films.
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Activation of Delta Opioid Receptors Induces Receptor Insertion and Neuropeptide Secretion
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Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.
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Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice.
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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
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Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.
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Analysis of the linker for activation of T cells (LAT) and the linker for activation of B cells (LAB) in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
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Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium.
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Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins.
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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.
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Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms.
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Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages.
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Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.
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Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells.
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Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes.
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BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.
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Bimatoprost, prostamide activity, and conventional drainage.
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Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
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Biological functions and transcriptional targets of CaRF in neurons.
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Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors.
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CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses.
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Ca(2+)/CaM-dependent kinases: from activation to function.
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Ca2+ channel nanodomains boost local Ca2+ amplitude.
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Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.
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Ca2+-activated Cl- channels at a glance.
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Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression.
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CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.
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Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.
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Calcium Signaling and Cardiac Arrhythmias.
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Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage.
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Calcium in Pancreatitis … Immune Cells, Too?
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Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.
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Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3',5'-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells.
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Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow.
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Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells.
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Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location.
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Calcium-myristoyl switches turn on new lights.
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Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines.
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Calmodulin regulation of excitation-contraction coupling in cardiac myocytes.
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Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.
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Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways.
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Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.
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Cellular and functional defects in a mouse model of heart failure.
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Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT.
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Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation.
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Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum.
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Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport.
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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.
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Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis.
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Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins.
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Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle.
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Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux.
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Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
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Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.
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Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow.
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Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea.
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Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.
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Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.
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Experience with moving visual stimuli drives the early development of cortical direction selectivity.
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Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells.
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Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.
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Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack.
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Gene delivery approaches to heart failure treatment.
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Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival.
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Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray.
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Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation.
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HDACs in skeletal muscle remodeling and neuromuscular disease.
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HIV-1 activates macrophages independent of Toll-like receptors.
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High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4.
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Homer modulates NFAT-dependent signaling during muscle differentiation.
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Human platelets exhibit chemotaxis using functional N-formyl peptide receptors.
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Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis.
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Hypoxia reprograms calcium signaling and regulates myoglobin expression.
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IL-1beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress.
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Identification of the components controlling inactivation of voltage-gated Ca2+ channels.
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Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion.
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Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6.
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Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation.
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Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset.
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Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
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Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes.
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Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2.
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LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling.
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Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.
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Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain.
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MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type.
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Mast cell desensitization inhibits calcium flux and aberrantly remodels actin.
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Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles.
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Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel.
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Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors.
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Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line.
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Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity.
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Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
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Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells.
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Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling.
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Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels.
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Multiple sources of internal calcium stores mediate ethanol-induced presynaptic inhibitory GABA release in the central nucleus of the amygdala in mice.
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Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment.
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
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Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.
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Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease.
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Mystery of biphasic defibrillation waveform efficacy is it calcium?
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NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia.
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Neural correlates of single-vessel haemodynamic responses in vivo.
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Neural dynamics underlying birdsong practice and performance.
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Neuronal activity-regulated gene transcription in synapse development and cognitive function.
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OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis.
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Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex.
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Optimal pulse length of insonification for Piezo1 activation and intracellular calcium response.
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Osmotic stress alters circadian cytosolic Ca2+
oscillations and OSCA1 is required in circadian gated stress adaptation.
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PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.
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Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity.
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Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.
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Plant "helper" immune receptors are Ca2+
-permeable nonselective cation channels.
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Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+
influx.
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Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway.
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Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL.
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Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.
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Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy.
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Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
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Protective role of transient pore openings in calcium handling by cardiac mitochondria.
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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation.
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Pulmonary edema post-cardioversion: a potential calcium signalling problem.
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Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes.
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RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
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Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.
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Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.
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Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.
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Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells.
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Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
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Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.
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S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.
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SOCE and STIM1 signaling in the heart: Timing and location matter.
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SOCE in the cardiomyocyte: the secret is in the chambers.
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STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle.
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STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
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STIM1-Ca2+ signaling in coronary sinus cardiomyocytes contributes to interatrial conduction.
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STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
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Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.
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Socking It to cardiac hypertrophy: STIM1-mediated Ca2+ entry in the cardiomyocyte.
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Soluble miniagrin enhances contractile function of engineered skeletal muscle.
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Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.
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Studying signal transduction in single dendritic spines.
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Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment.
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Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.
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Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation.
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TRP channels in disease.
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TRPC1 channels are critical for hypertrophic signaling in the heart.
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TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.
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TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.
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TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.
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TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
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TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells.
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TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.
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TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.
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Targeted inhibition of Ca2+ /calmodulin signaling exacerbates the dystrophic phenotype in mdx mouse muscle.
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The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.
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The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.
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The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.
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The calmodulin-binding transcription factor SIGNAL RESPONSIVE1 is a novel regulator of glucosinolate metabolism and herbivory tolerance in Arabidopsis.
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The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation.
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The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.
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The junctophilin family of proteins: from bench to bedside.
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The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling.
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The role of store-operated calcium influx in skeletal muscle signaling.
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Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells.
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Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
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Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets.
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Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
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Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia.
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Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
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Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.
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Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.
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Vertebrate Reproduction.
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Voltage-Gated Calcium Channels in Nonexcitable Tissues.
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[Extracellular Ca2+ signaling: first messenger in animals and plants].
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beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation.
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p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes.
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p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
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β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.
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β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.
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Keywords of People
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Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
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Jabba, Sairam V.,
Research Scientist,
Anesthesiology
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Jordt, Sven Eric,
Associate Professor in Anesthesiology,
Pharmacology & Cancer Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Turner, Dennis Alan,
Professor of Neurosurgery,
Biomedical Engineering
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Zhong, Pei,
Professor in the Department of Mechanical Engineering and Materials Science,
Thomas Lord Department of Mechanical Engineering and Materials Science