Calcium Signaling

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  Subject Areas on Research

  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. 
  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A bird's eye view: top down intracellular analyses of auditory selectivity for learned vocalizations. 
  • A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. 
  • A method to measure myocardial calcium handling in adult Drosophila. 
  • A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels. 
  • A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. 
  • A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. 
  • A sharp-edge-based acoustofluidic chemical signal generator. 
  • ATP induces Ca(2+) signaling in human chondrons cultured in three-dimensional agarose films. 
  • Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. 
  • Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. 
  • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. 
  • Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice. 
  • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Apolipoprotein E and Alzheimer's disease: signal transduction mechanisms. 
  • Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages. 
  • Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. 
  • Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • Bimatoprost, prostamide activity, and conventional drainage. 
  • Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs. 
  • Biological functions and transcriptional targets of CaRF in neurons. 
  • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 
  • CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses. 
  • Ca(2+)/CaM-dependent kinases: from activation to function. 
  • Ca2+ channel nanodomains boost local Ca2+ amplitude. 
  • Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. 
  • Ca2+-activated Cl- channels at a glance. 
  • Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. 
  • CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. 
  • Calcium Signaling and Cardiac Arrhythmias. 
  • Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3',5'-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells. 
  • Calcium signaling regulates ventricular hypertrophy during development independent of contraction or blood flow. 
  • Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location. 
  • Calcium-myristoyl switches turn on new lights. 
  • Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines. 
  • Calmodulin as a direct detector of Ca2+ signals. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Cell signalling. Calmodulin at the channel gate. 
  • Cellular and functional defects in a mouse model of heart failure. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation. 
  • Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. 
  • Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. 
  • Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. 
  • Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis. 
  • Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins. 
  • Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. 
  • Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. 
  • Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow. 
  • Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea. 
  • Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes. 
  • Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Experience with moving visual stimuli drives the early development of cortical direction selectivity. 
  • Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells. 
  • Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. 
  • GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. 
  • Gene delivery approaches to heart failure treatment. 
  • Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. 
  • HDACs in skeletal muscle remodeling and neuromuscular disease. 
  • HIV-1 activates macrophages independent of Toll-like receptors. 
  • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • How does calcium trigger neurotransmitter release? 
  • Human platelets exhibit chemotaxis using functional N-formyl peptide receptors. 
  • Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • IL-1beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress. 
  • Identification of the components controlling inactivation of voltage-gated Ca2+ channels. 
  • Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion. 
  • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. 
  • Inducible expression of the alpha2-macroglobulin signaling receptor in response to antigenic stimulation: a study of second messenger generation. 
  • Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. 
  • Inside-out Ca(2+) signalling prompted by STIM1 conformational switch. 
  • Interaction between the second messengers cAMP and Ca2+ in mouse presynaptic taste cells. 
  • Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes. 
  • Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. 
  • Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. 
  • Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes. 
  • Ligation of the alpha2M* signaling receptor regulates synthesis of cytosolic phospholipase A2. 
  • LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling. 
  • Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress. 
  • Local calcium release in dendritic spines required for long-term synaptic depression. 
  • Local calcium signaling in neurons. 
  • Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • Mast cell desensitization inhibits calcium flux and aberrantly remodels actin. 
  • Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel. 
  • Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors. 
  • Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line. 
  • Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. 
  • Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. 
  • Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells. 
  • Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. 
  • Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channels. 
  • Muscarinic acetylcholine receptor M3 modulates odorant receptor activity via inhibition of β-arrestin-2 recruitment. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. 
  • Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. 
  • Mystery of biphasic defibrillation waveform efficacy is it calcium? 
  • NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. 
  • Neural correlates of single-vessel haemodynamic responses in vivo. 
  • Neuronal activity-regulated gene transcription in synapse development and cognitive function. 
  • OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis. 
  • Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex. 
  • PIP5K1α promotes myogenic differentiation via AKT activation and calcium release. 
  • Paired-pulse potentiation of alpha7-containing nAChRs in rat hippocampal CA1 stratum radiatum interneurones. 
  • Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. 
  • Plasminogen activator inhibitor-1 regulates myoendothelial junction formation. 
  • Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway. 
  • Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. 
  • Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy. 
  • Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. 
  • Pulmonary edema post-cardioversion: a potential calcium signalling problem. 
  • Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes. 
  • RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses. 
  • Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. 
  • Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. 
  • Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. 
  • Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. 
  • Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. 
  • Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury. 
  • S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes. 
  • STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. 
  • STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. 
  • STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. 
  • Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. 
  • Signaling by olfactory receptor neurons near threshold. 
  • Simultaneous GCaMP6-based fiber photometry and fMRI in rats. 
  • Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism. 
  • Socking It to cardiac hypertrophy: STIM1-mediated Ca2+ entry in the cardiomyocyte. 
  • Soluble miniagrin enhances contractile function of engineered skeletal muscle. 
  • Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. 
  • Studying signal transduction in single dendritic spines. 
  • Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. 
  • Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. 
  • TRP channels in disease. 
  • TRPC1 channels are critical for hypertrophic signaling in the heart. 
  • TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. 
  • TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. 
  • TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. 
  • TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. 
  • TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. 
  • TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. 
  • The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. 
  • The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. 
  • The calmodulin-binding transcription factor SIGNAL RESPONSIVE1 is a novel regulator of glucosinolate metabolism and herbivory tolerance in Arabidopsis. 
  • The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation. 
  • The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. 
  • The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. 
  • The junctophilin family of proteins: from bench to bedside. 
  • The role of F-actin in hypo-osmotically induced cell volume change and calcium signaling in anulus fibrosus cells. 
  • The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling. 
  • The role of store-operated calcium influx in skeletal muscle signaling. 
  • The sequence of events that underlie quantal transmission at central glutamatergic synapses. 
  • Tissue factor is the receptor for plasminogen type 1 on 1-LN human prostate cancer cells. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. 
  • Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
  • Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. 
  • Vertebrate Reproduction. 
  • Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. 
  • [Extracellular Ca2+ signaling: first messenger in animals and plants]. 
  • beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation. 
  • β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility. 
  • β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering