K562 Cells
-
Subject Areas on Research
- A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse.
- A novel triple purge strategy for eliminating chronic myelogenous leukemia (CML) cells from autografts.
- Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.
- Architecture of the human regulatory network derived from ENCODE data.
- Atypical features of familial hemophagocytic lymphohistiocytosis.
- BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia.
- BP1, a new homeobox gene, is frequently expressed in acute leukemias.
- Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.
- CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion.
- Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells.
- Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering.
- Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells.
- DNA methylation alterations in response to pesticide exposure in vitro.
- Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis.
- Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene.
- Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9.
- Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.
- Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer.
- Force measurements of the alpha5beta1 integrin-fibronectin interaction.
- Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.
- Genome-wide quantification of the effects of DNA methylation on human gene regulation.
- Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro.
- Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.
- High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene.
- Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.
- Histone modifications at human enhancers reflect global cell-type-specific gene expression.
- Identification and characterization of cell type-specific and ubiquitous chromatin regulatory structures in the human genome.
- Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.
- Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.
- Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.
- Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration.
- Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization.
- Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing.
- Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.
- Targeting aldehyde dehydrogenase: a potential approach for cell labeling.
- Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.
- Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.
- Tumor-specific recognition of human myeloma cells by idiotype-induced CD8(+) T cells.
- TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells.
- Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.
- WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.
- microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.
-
Keywords of People
- Barker, Piers Christopher Andrew, Professor of Pediatrics, Pediatrics, Cardiology
- Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering