Genes, Essential

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  Subject Areas on Research

  • A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function. 
  • An individualized predictor of health and disease using paired reference and target samples. 
  • De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome. 
  • Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. 
  • Functions of fission yeast orp2 in DNA replication and checkpoint control. 
  • Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. 
  • Hybrid male sterility in Mimulus (Phrymaceae) is associated with a geographically restricted mitochondrial rearrangement. 
  • Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. 
  • SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. 
  • Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression. 
  • The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans. 
  • The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. 
  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. 
  • Threonine biosynthetic genes are essential in Cryptococcus neoformans.