Hydrogels

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  Subject Areas on Research

  • 3-Dimensional spatially organized PEG-based hydrogels for an aortic valve co-culture model. 
  • 3D Culture Facilitates VEGF-Stimulated Endothelial Differentiation of Adipose-Derived Stem Cells. 
  • 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout. 
  • 3D printing of high-strength, porous, elastomeric structures to promote tissue integration of implants. 
  • A 3D Poly(ethylene glycol)-based Tumor Angiogenesis Model to Study the Influence of Vascular Cells on Lung Tumor Cell Behavior. 
  • A human pluripotent stem cell platform for assessing developmental neural toxicity screening. 
  • A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. 
  • A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling. 
  • Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks 
  • Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs. 
  • Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing. 
  • Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. 
  • Adding Dynamic Biomolecule Signaling to Hydrogel Systems via Tethered Photolabile Cell-Adhesive Proteins. 
  • An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment. 
  • Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue. 
  • Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue. 
  • Anisotropic poly(ethylene glycol)/polycaprolactone hydrogel-fiber composites for heart valve tissue engineering. 
  • Anisotropic scaffolds facilitate enhanced neurite extension in vitro. 
  • Application of hydrogels in heart valve tissue engineering. 
  • Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds. 
  • Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies. 
  • Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. 
  • Biocompatible hydrogels by oxime Click chemistry 
  • Biomaterials for the central nervous system. 
  • Biomimetic Hydrogels with Immobilized EphrinA1 for Therapeutic Angiogenesis 
  • Biomimetic hydrogels with pro-angiogenic properties. 
  • Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling. 
  • Cartilage-like mechanical properties of poly (ethylene glycol)-diacrylate hydrogels. 
  • Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption. 
  • Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. 
  • Cell migration through defined, synthetic ECM analogs. 
  • Cell-Compatible, Site-Specific Covalent Modification of Hydrogel Scaffolds Enables User-Defined Control over Cell-Material Interactions. 
  • Chemical sintering generates uniform porous hyaluronic acid hydrogels 
  • Chemically Orthogonal Protein Ligation Domains for Independent Control of Hydrogel Modification with Adhesive Ligands and Growth Factors. 
  • Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. 
  • Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels. 
  • Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels. 
  • Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells. 
  • Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells. 
  • Click by Click Microporous Annealed Particle (MAP) Scaffolds. 
  • Complexation hydrogels for oral protein delivery: an in vitro assessment of the insulin transport-enhancing effects following dissolution in simulated digestive fluids. 
  • Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells. 
  • Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly (ethylene glycol) hydrogels 
  • Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Covalently-immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern 
  • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach 
  • Dendritic macromers as in situ polymerizing biomaterials for securing cataract incisions. 
  • Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. 
  • Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Dorsal root ganglia neurite extension is inhibited by mechanical and chondroitin sulfate-rich interfaces. 
  • Dressings for chronic wounds. 
  • Dynamic culture yields engineered myocardium with near-adult functional output. 
  • ECM production of primary human and bovine chondrocytes in hybrid PEG hydrogels containing type I collagen and hyaluronic acid. 
  • Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels. 
  • Elastin-Like Polypeptides for Biomedical Applications. 
  • Elastin-like polypeptides: biomedical applications of tunable biopolymers. 
  • Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models. 
  • Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. 
  • Encapsulation of Adenovirus BMP2-Transduced Cells with PEGDA Hydrogels Allows Bone Formation in the Presence of Immune Response. 
  • Encapsulation of PEGylated low-molecular-weight PEI polyplexes in hyaluronic acid hydrogels reduces aggregation 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Engineered skeletal muscle tissue networks with controllable architecture. 
  • Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells. 
  • Engineering superficial zone features in tissue engineered cartilage. 
  • Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation. 
  • Enhanced Release of Molecules upon Ultraviolet (UV) Light Irradiation from Photoresponsive Hydrogels Prepared from Bifunctional Azobenzene and Four-Arm Poly(ethylene glycol). 
  • Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine. 
  • Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. 
  • Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells. 
  • Epitope tagging for tracking elastin-like polypeptides. 
  • Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels. 
  • Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering. 
  • Fabrication and mechanical evaluation of anatomically-inspired quasilaminate hydrogel structures with layer-specific formulations. 
  • Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels. 
  • Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. 
  • Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves. 
  • Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins. 
  • Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs. 
  • Getting there is half the battle: recent advances in delivering therapeutics 
  • Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. 
  • Glycosaminoglycan-binding hydrogels enable mechanical control of human pluripotent stem cell self-renewal. 
  • Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration. 
  • Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres. 
  • High-Strength Hydrogel Attachment through Nanofibrous Reinforcement. 
  • Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. 
  • Hyaluronan Hydrogels for a Biomimetic Spongiosa Layer of Tissue Engineered Heart Valve Scaffolds. 
  • Hyaluronic acid and fibrin hydrogels with concentrated DNA/PEI polyplexes for local gene delivery 
  • Hyaluronic acid based low viscosity hydrogel as a novel carrier for Convection Enhanced Delivery of CAR T cells. 
  • Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation 
  • Hydrogel ocular sealant for clear corneal incisions in cataract surgery. 
  • Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery. 
  • Hydrogels as carriers for stem cell transplantation. 
  • Hydrogels for brain repair after stroke: an emerging treatment option 
  • Hydrogels formed by multiple peptide ligation reactions to fasten corneal transplants. 
  • Hydrogels muscle their way into new territory. 
  • Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability 
  • Imine hydrogels with tunable degradability for tissue engineering 
  • Immuno-suppressive hydrogels enhance allogeneic MSC survival after transplantation in the injured brain. 
  • Implanted Nanosensors in Marine Organisms for Physiological Biologging: Design, Feasibility, and Species Variability. 
  • Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules. 
  • In situ cross-linking of elastin-like polypeptide block copolymers for tissue repair. 
  • In situ forming injectable hydrogels for drug delivery and wound repair. 
  • In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. 
  • In situ polymerized hydrogels for repairing scleral incisions used in pars plana vitrectomy procedures. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • Increasing the maximum achievable strain of a covalent polymer gel through the addition of mechanically invisible cross-links. 
  • Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels. 
  • Inhibition of implant-associated infections via nitric oxide release. 
  • Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy. 
  • Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke. 
  • Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion 
  • Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels. 
  • Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering. 
  • It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies. 
  • Lipid-based microtubular drug delivery vehicles. 
  • Lipid-coated microgels for the triggered release of doxorubicin. 
  • Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury model. 
  • Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats. 
  • Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes. 
  • Maximizing phenotype constraint and extracellular matrix production in primary human chondrocytes using arginine-glycine-aspartate concentration gradient hydrogels. 
  • Measuring macrodiffusion coefficients in microbicide hydrogels via postphotoactivation scanning. 
  • Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding. 
  • Micron-scale spatially patterned, covalently immobilized vascular endothelial growth factor on hydrogels accelerates endothelial tubulogenesis and increases cellular angiogenic responses. 
  • Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. 
  • Micropatterning of poly(ethylene glycol) diacrylate hydrogels. 
  • Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer. 
  • Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells. 
  • Mitral valvular interstitial cell responses to substrate stiffness depend on age and anatomic region. 
  • Modulating the mechanical properties of self-assembled peptide hydrogels via native chemical ligation. 
  • Mold-casted non-degradable, islet macro-encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice. 
  • Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells. 
  • Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices. 
  • Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration. 
  • Multilayer microfluidic PEGDA hydrogels. 
  • Multilayer microfluidic poly(ethylene glycol) diacrylate hydrogels. 
  • Multivascular networks and functional intravascular topologies within biocompatible hydrogels. 
  • Neural network analysis identifies scaffold properties necessary for in vitro chondrogenesis in elastin-like polypeptide biopolymer scaffolds. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. 
  • Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice 
  • Novel light-driven functional AgNPs induce cancer death at extra low concentrations. 
  • Nucleic Acid Delivery from Granular Hydrogels. 
  • Oligo(trimethylene carbonate)-poly(ethylene glycol)-oligo(trimethylene carbonate) triblock-based hydrogels for cartilage tissue engineering. 
  • PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. 
  • Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds. 
  • Peptide-functionalized oxime hydrogels with tunable mechanical properties and gelation behavior. 
  • Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides. 
  • Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering. 
  • Photolithographic patterning of polyethylene glycol hydrogels. 
  • Physically Associated Synthetic Hydrogels with Long-Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation 
  • Platelet adhesion on a bioresorbable poly(propylene fumarate-co-ethylene glycol) copolymer. 
  • Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation. 
  • Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration. 
  • Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery. 
  • Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. 
  • Polymer hydrogels: Chaperoning vaccines. 
  • Porous hyaluronic acid hydrogels for localized nonviral DNA delivery in a diabetic wound healing model 
  • Primary human chondrocyte extracellular matrix formation and phenotype maintenance using RGD-derivatized PEGDM hydrogels possessing a continuous Young's modulus gradient. 
  • Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2-and 3-dimensions 
  • Protein polymer hydrogels by in situ, rapid and reversible self-gelation. 
  • Protein-patterned hydrogels: Customized cell microenvironments. 
  • Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migration. 
  • Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution. 
  • Rapid self-healing hydrogels. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Rheological properties of cysteine-containing elastin-like polypeptide solutions and hydrogels. 
  • Screening of hyaluronic acid-poly(ethylene glycol) composite hydrogels to support intervertebral disc cell biosynthesis using artificial neural network analysis. 
  • Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. 
  • Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury. 
  • Small molecule delivery across a perforated artificial membrane by thermoreversible hydrogel poloxamer 407. 
  • Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering. 
  • Stiffness of Protease Sensitive and Cell Adhesive PEG Hydrogels Promotes Neovascularization In Vivo. 
  • Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine. 
  • Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins 
  • Surface- and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles. 
  • Surface-and hydrogel-mediated delivery of nucleic acid nanoparticles 
  • Sustained in vivo gene delivery from agarose hydrogel prolongs nonviral gene expression in skin. 
  • Sustained release of plasmid DNA using lipid microtubules and agarose hydrogel. 
  • Swelling and mechanical behaviors of chemically cross-linked hydrogels of elastin-like polypeptides. 
  • Switchable friction of stimulus-responsive hydrogels. 
  • Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. 
  • Synthetic ECM: Bioactive Synthetic Hydrogels for 3D Tissue Engineering. 
  • Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesis. 
  • Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain 
  • Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles. 
  • Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery. 
  • Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery 
  • Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity. 
  • The effect of enzymatically degradable poly (ethylene glycol) hydrogels on smooth muscle cell phenotype 
  • The influence of physical structure and charge on neurite extension in a 3D hydrogel scaffold. 
  • The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide. 
  • The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. 
  • The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels 
  • Three dimensional tubular structure self-assembled by vascular mesenchymal cells at stiffness interfaces of hydrogels 
  • Three-dimensional culture systems in cancer research: Focus on tumor spheroid model. 
  • Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. 
  • Three-dimensional photolithographic micropatterning: a novel tool to probe the complexities of cell migration. 
  • Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs. 
  • Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis. 
  • Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings. 
  • Using Tools from Optogenetics to Create Light-Responsive Biomaterials: LOVTRAP-PEG Hydrogels for Dynamic Peptide Immobilization. 
  • Utilizing cell–matrix interactions to modulate gene transfer to stem cells inside hyaluronic acid hydrogels 
  • Val-ala-pro-gly, an elastin-derived non-integrin ligand: smooth muscle cell adhesion and specificity. 
  • Visible light photoinitiation of mesenchymal stem cell-laden bioresponsive hydrogels. 
  • YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function. 
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  Keywords of People

  • Bursac, Nenad, Professor of Biomedical Engineering, Biomedical Engineering
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering