Subject Areas on Research
- Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.
- Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans.
- Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
- Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.
- Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.
- Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.
- Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
- Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
- Spliceosomal immunophilins.
- Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
- TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals.
- Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.
- The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.
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