Troponin T

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  Subject Areas on Research

  • A biomarker-based risk score to predict death in patients with atrial fibrillation: the ABC (age, biomarkers, clinical history) death risk score. 
  • A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C. 
  • A multimarker multi-time point-based risk stratification strategy in acute heart failure: results from the RELAX-AHF trial. 
  • A randomized, placebo-controlled trial of early eptifibatide for non-ST-segment elevation acute coronary syndromes. 
  • A rapid troponin I assay is not optimal for determination of troponin status and prediction of subsequent cardiac events at suspicion of unstable coronary syndromes. 
  • Analytical performance evaluation of the Elecsys® Troponin T Gen 5 STAT assay. 
  • Assessment of Biomarkers of Myocardial injury, Inflammation, and Renal Function in Heart Failure With Reduced Ejection Fraction: The VICTORIA Biomarker Substudy. 
  • Association between short-term exposure to ambient fine particulate matter and myocardial injury in the CATHGEN cohort. 
  • Association of Serial High-Sensitivity Cardiac Troponin T With Subsequent Cardiovascular Events in Patients Stabilized After Acute Coronary Syndrome: A Secondary Analysis From IMPROVE-IT. 
  • Association of cardiac biomarkers with acute kidney injury after cardiac surgery: A multicenter cohort study. 
  • Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study. 
  • Association of troponin T, detected with highly sensitive assay, and outcomes in infective endocarditis. 
  • Baseline Q waves as a prognostic modulator in patients with ST-segment elevation: insights from the PLATO trial. 
  • Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: the paragon-B troponin T substudy. 
  • Biomarker-Based Risk Model to Predict Cardiovascular Mortality in Patients With Stable Coronary Disease. 
  • Biomarkers and heart failure events in patients with atrial fibrillation in the ARISTOTLE trial evaluated by a multi-state model. 
  • Biomarkers in cardiovascular clinical trials: past, present, future. 
  • CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study. 
  • Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy. 
  • Cancer Survivorship and Subclinical Myocardial Damage. 
  • Cardiac Troponin and Risk Stratification in Ischemic Heart Disease. 
  • Cardiac markers: point of care testing. 
  • Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon. 
  • Cardiac troponin T and cardiac troponin I: relative values in short-term risk stratification of patients with acute coronary syndromes. GUSTO-IIa Investigators. 
  • Cardiac troponin T levels for risk stratification in acute myocardial ischemia. GUSTO IIA Investigators. 
  • Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial. 
  • Cardiac troponins in acute coronary syndromes. 
  • Cardiac troponins in congestive heart failure. 
  • Changes in cardiac troponin T measurements are associated with adverse cardiac events in patients with chronic kidney disease. 
  • Chicken perinatal troponin Ts are generated by a combination of novel and phylogenetically conserved alternative splicing pathways. 
  • Comparison of cardiac troponin T versus creatine kinase-MB for risk stratification in a chest pain evaluation unit. 
  • Comparison of cardiac troponins I and T measured with high-sensitivity methods for evaluation of prognosis in atrial fibrillation: an ARISTOTLE substudy. 
  • Designing a Better Mousetrap: Reflections on the November 28, 2017, US Food and Drug Administration Meeting on Next-Generation "High-Sensitivity" Cardiac Troponin Assays to Diagnose Myocardial Infarction. 
  • Do cardiac troponins provide prognostic insight in hemodialysis patients? 
  • Does the discharge ECG provide additional prognostic insight(s) in non-ST elevation ACS patients from that acquired on admission? 
  • Dose-Response to Sacubitril/Valsartan in Patients With Heart Failure and Reduced Ejection Fraction. 
  • Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure. 
  • Effect of different troponin T-tropomyosin combinations on thin filament activation. 
  • Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes. 
  • Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practices™ systematic review. 
  • Efficacy of High-Sensitivity Troponin T in Identifying Very-Low-Risk Patients With Possible Acute Coronary Syndrome. 
  • Elevated serum cardiac markers predict coronary artery disease in patients with a history of heart failure who present with chest pain: insights from the i*trACS registry. 
  • Expression of a novel combination of fast and slow troponin T isoforms in rabbit extraocular muscles. 
  • Heart Failure Duration and Mechanistic Efficacy of Sacubitril/Valsartan in Heart Failure With Reduced Ejection Fraction. 
  • Heart failure with preserved left ventricular systolic function among patients with non-ST-segment elevation acute coronary syndromes. 
  • High-Sensitivity Troponin in Acute Heart Failure Triage. 
  • High-Sensitivity Troponin in Noncardiac Surgery: Pandora's Box or Opportunity for Precision Perioperative Care? 
  • High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of incident heart failure in patients with CKD: the Chronic Renal Insufficiency Cohort (CRIC) Study. 
  • High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin. 
  • Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction. 
  • Identification of a fetal exon in the human fast troponin T gene. 
  • Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis. 
  • Incorporation of Biomarkers Into Risk Assessment for Allocation of Antihypertensive Medication According to the 2017 ACC/AHA High Blood Pressure Guideline: A Pooled Cohort Analysis. 
  • Incremental prognostic value of biomarkers beyond the GRACE (Global Registry of Acute Coronary Events) score and high-sensitivity cardiac troponin T in non-ST-elevation acute coronary syndrome. 
  • Interpreting cardiac troponin results from high-sensitivity assays in chronic kidney disease without acute coronary syndrome. 
  • Longitudinal variation in muscle protein expression and contraction kinetics of largemouth bass axial muscle. 
  • Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes. 
  • Moving toward a new definition of acute myocardial infarction for the 21st century: status of the ESC/ACC consensus conference. European Society of Cardiology and American College of Cardiology. 
  • Multimarker Risk Stratification in Patients With Acute Myocardial Infarction. 
  • Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries. 
  • Myocardial infarction rule-out in the emergency department: are high-sensitivity troponins the answer?: comment on "One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T". 
  • Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. 
  • N-terminal amino acid sequences of three functionally different troponin T isoforms from rabbit fast skeletal muscle. 
  • N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a Global Utilization of Strategies To Open occluded arteries (GUSTO)-IV substudy. 
  • National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical characteristics and utilization of biochemical markers in acute coronary syndromes. 
  • National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure. 
  • National Academy of Clinical Biochemistry and IFCC Committee for Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: Analytical issues for biochemical markers of acute coronary syndromes. 
  • Origin of fetal troponin T: developmentally regulated splicing of a new exon in the fast troponin T gene. 
  • Outcomes after planned invasive or conservative treatment strategy in patients with non-ST-elevation acute coronary syndrome and a normal value of high sensitivity troponin at randomisation: A Platelet Inhibition and Patient Outcomes (PLATO) trial biomarker substudy. 
  • Outcomes associated with small changes in normal-range cardiac markers. 
  • Patterns of troponin T expression in mammalian fast, slow and promiscuous muscle fibres. 
  • Performance of a body surface mapping system using emergency physician real-time interpretation. 
  • Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. 
  • Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. 
  • Physiologically regulated alternative splicing patterns of fast troponin T RNA are conserved in mammals. 
  • Postoperative ST-segment elevation: was vasospasm caused by anaphylaxis or by its treatment with epinephrine? 
  • Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC). 
  • Prevalence and prognostic significance of preprocedural cardiac troponin elevation among patients with stable coronary artery disease undergoing percutaneous coronary intervention: results from the evaluation of drug eluting stents and ischemic events registry. 
  • Prognostic implications of low level cardiac troponin elevation using high-sensitivity cardiac troponin T. 
  • Prognostic performance of a high-sensitivity cardiac troponin I assay in patients with non-ST-elevation acute coronary syndrome. 
  • Prognostic value of troponins in patients with non-ST-segment elevation acute coronary syndromes and chronic kidney disease. 
  • Prospective evaluation of the association between cardiac troponin T and markers of disturbed erythropoiesis in patients with heart failure. 
  • RNA-Mediated Reprogramming of Primary Adult Human Dermal Fibroblasts into c-kit(+) Cardiac Progenitor Cells. 
  • Rapid fusion between mesenchymal stem cells and cardiomyocytes yields electrically active, non-contractile hybrid cells. 
  • Rationale and design of the pilot randomized study of nesiritide versus dobutamine in heart failure (PRESERVD-HF). 
  • Redefining the Gold Standard of Myocardial Infarction Using Troponin T. 
  • Relationship between risk stratification by cardiac troponin level and adherence to guidelines for non-ST-segment elevation acute coronary syndromes. 
  • Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk. 
  • Repeated Measurements of Cardiac Biomarkers in Atrial Fibrillation and Validation of the ABC Stroke Score Over Time. 
  • Response by McCord et al to Letter Regarding Article, "Designing a Better Mousetrap: Reflections on the November 28, 2017, US Food and Drug Administration Meeting on Next-Generation "High-Sensitivity" Cardiac Troponin Assays to Diagnose Myocardial Infarction". 
  • Review: A single hs-cTnT with a cutpoint < limit of detection plus a nonischemic ECG can rule out acute MI. 
  • Risk stratification in acute coronary syndromes: the need for continued vigilance in "low-risk" patients. 
  • Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction. GUSTOIII Investigators. Global Use of Strategies To Open Occluded Coronary Arteries. 
  • Rostral-caudal variation in troponin T and parvalbumin correlates with differences in relaxation rates of cod axial muscle. 
  • SARS-CoV-2 Cardiac Involvement in Young Competitive Athletes. 
  • SUPPORT-1 (Subjects Undergoing PCI and Perioperative Reperfusion Treatment): A Prospective, Randomized Trial of CMX-2043 in Patients Undergoing Elective Percutaneous Coronary Intervention. 
  • Serial high sensitivity cardiac troponin T measurement in acute heart failure: insights from the RELAX-AHF study. 
  • Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice. 
  • Short- and long-term risk stratification in acute coronary syndromes: the added value of quantitative ST-segment depression and multiple biomarkers. 
  • The 99th percentile upper reference limit for the 5th generation cardiac troponin T assay in the United States. 
  • The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF). 
  • The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure. 
  • The extent of amino-terminal heterogeneity in rabbit fast skeletal muscle troponin T. 
  • The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography. 
  • The utility of C4d, C9, and troponin T immunohistochemistry in acute myocardial infarction. 
  • The utility of troponin measurement to detect myocardial infarction: review of the current findings. 
  • Thresholds for the electrocardiographic change range of biochemical markers of acute myocardial infarction (GUSTO-IIa data). 
  • Time for a Renewed Focus on the DASH-Low Sodium Diet. 
  • Transitions from fetal to fast troponin T isoforms are coordinated with changes in tropomyosin and alpha-actinin isoforms in developing rabbit skeletal muscle. 
  • Trends in Use of Biomarker Protocols for the Evaluation of Possible Myocardial Infarction. 
  • Troponin Elevation After Colorectal Surgery: Significance and Management. 
  • Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients. 
  • Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial. 
  • Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. 
  • Troponin T levels in patients with acute heart failure: clinical and prognostic significance of their detection and release during hospitalisation. 
  • Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice. 
  • Troponin and other cardiac markers: role in management of acute coronary syndromes. 
  • Troponin-T and N-terminal pro-B-type natriuretic peptide predict mortality benefit from coronary revascularization in acute coronary syndromes: a GUSTO-IV substudy. 
  • Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation. 
  • Use of High-Sensitivity Troponin T to Identify Patients With Acute Heart Failure at Lower Risk for Adverse Outcomes: An Exploratory Analysis From the RELAX-AHF Trial. 
  • Usefulness of biomarkers for predicting long-term mortality in patients with diabetes mellitus and non-ST-elevation acute coronary syndromes (a GUSTO IV substudy). 
  • Using Sex-specific Cutoffs for High-sensitivity Cardiac Troponin T to Diagnose Acute Myocardial Infarction. 
  • Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation. 
  • Value of serial troponin T measures for early and late risk stratification in patients with acute coronary syndromes. The GUSTO-IIa Investigators. 
  • Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Granger, Christopher Bull, Professor of Medicine, School of Nursing
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology