Base Pair Mismatch

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  Subject Areas on Research

  • A defined human system that supports bidirectional mismatch-provoked excision. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes. 
  • Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models. 
  • Association between IHC and MSI testing to identify mismatch repair-deficient patients with ovarian cancer. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. 
  • Conversion of diploidy to haploidy. 
  • DNA mismatch repair and genetic instability. 
  • DNA mismatch repair: functions and mechanisms. 
  • DNA repair: a double-edged sword. 
  • DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset. 
  • Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents. 
  • Differential and simultaneous adenosine di- and triphosphate binding by MutS. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs. 
  • Dynamic basis for dG•dT misincorporation via tautomerization and ionization. 
  • Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. 
  • Faster algorithms for optimal multiple sequence alignment based on pairwise comparisons. 
  • Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae. 
  • Hereditary nonpolyposis colorectal cancer: preventive management. 
  • High-throughput genotyping with single nucleotide polymorphisms. 
  • Human exonuclease I is required for 5' and 3' mismatch repair. 
  • Involvement of the beta clamp in methyl-directed mismatch repair in vitro. 
  • Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast. 
  • Mechanism of 5'-directed excision in human mismatch repair. 
  • Mechanisms in eukaryotic mismatch repair. 
  • Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops. 
  • Methyl-directed repair of DNA base-pair mismatches in vitro. 1983. 
  • Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma. 
  • Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts. 
  • Modulation of MutS ATP hydrolysis by DNA cofactors. 
  • MutL traps MutS at a DNA mismatch. 
  • MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta. 
  • PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro. 
  • Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes. 
  • Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. 
  • Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study. 
  • Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis. 
  • Structure of the human MutSalpha DNA lesion recognition complex. 
  • Structures of mismatch replication errors observed in a DNA polymerase. 
  • Tagging single nucleotide polymorphisms in MBD4 are associated with risk of lung cancer in a Chinese population. 
  • Targeting AID to the Ig genes. 
  • The generation of antibody diversity through somatic hypermutation and class switch recombination. 
  • The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. 
  • The yeast HSM3 gene is not involved in DNA mismatch repair in rapidly dividing cells. 
  • Variation in efficiency of DNA mismatch repair at different sites in the yeast genome. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology