Manganese Poisoning

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  Subject Areas on Research

  • Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning. 
  • Fibroblasts that express aromatic amino acid decarboxylase have increased sensitivity to the synergistic cytotoxicity of L-dopa and manganese. 
  • Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain. 
  • Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. 
  • Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. 
  • Use of non-mammalian alternative models for neurotoxicological study.