Caspases

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  Subject Areas on Research

  • A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. 
  • A caspase homolog keeps CED-3 in check. 
  • A decade of caspases. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A loss-of-function RNA interference screen for molecular targets in cancer. 
  • A non-transformed oligodendrocyte precursor cell line, OL-1, facilitates studies of insulin-like growth factor-I signaling during oligodendrocyte development. 
  • A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. 
  • A novel role for XIAP in copper homeostasis through regulation of MURR1. 
  • A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2. 
  • A review of molecular mechanisms linked to potential renal injury agents in tropical rural farming communities. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. 
  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Acute pancreatitis induces FasL gene expression and apoptosis in the liver. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma. 
  • An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. 
  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. 
  • Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism. 
  • Angiotensin II attenuates chemical hypoxia-induced caspase-3 activation in primary cortical neuronal cultures. 
  • ApoE genotype-specific inhibition of apoptosis. 
  • Apoptosis and NF-kappa B: the FADD connection. 
  • Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). 
  • Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. 
  • Apoptosis induction by p38 MAPK inhibitor in human colon cancer cells. 
  • Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. 
  • Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP. 
  • Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. 
  • Apoptotic cell death in disease-Current understanding of the NCCD 2023. 
  • Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria. 
  • Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesis. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. 
  • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 
  • Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. 
  • Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition. 
  • Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. 
  • Caspase 8 is absent or low in many ex vivo gliomas. 
  • Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. 
  • Caspase cleavage is not for everyone. 
  • Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. 
  • Caspase-11 protects against bacteria that escape the vacuole. 
  • Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. 
  • Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase. 
  • Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. 
  • Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. 
  • Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis. 
  • Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma. 
  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Caspases and IAPs: a dance of death ensures cell survival. 
  • Caspases and kinases in a death grip. 
  • Caspases: an ancient cellular sword of Damocles. 
  • Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy. 
  • Cellular mechanisms controlling caspase activation and function. 
  • Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival. 
  • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. 
  • Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. 
  • Conversion of Bcl-2 to a Bax-like death effector by caspases. 
  • Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2. 
  • Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNγ Licensing. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. 
  • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. 
  • Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. 
  • Detection of cytosolic bacteria by inflammatory caspases. 
  • Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated. 
  • Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. 
  • Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants. 
  • Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. 
  • Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade. 
  • Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal. 
  • Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor. 
  • Diverse functions within the IAP family. 
  • Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. 
  • Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. 
  • Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. 
  • Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. 
  • Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. 
  • Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. 
  • Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells. 
  • Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice. 
  • Evidence that non-caspase proteases are required for chromatin degradation during apoptosis. 
  • Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Fanconi anemia complementation group A cells are hypersensitive to chromium(VI)-induced toxicity. 
  • Filling a GAP(DH) in caspase-independent cell death. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Gasdermins: Effectors of Pyroptosis. 
  • Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. 
  • Going up in flames: necrotic cell injury and inflammatory diseases. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. 
  • Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? 
  • High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. 
  • Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. 
  • IAP proteins: sticking it to Smac. 
  • IL-7 enhances the survival and maintains the size of naive T cells. 
  • IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition. 
  • Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. 
  • Identification of high caspase-3 mRNA expression as a unique signature profile for extremely old individuals. 
  • Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells. 
  • Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase. 
  • Induction of apoptosis by the novel retinoid AHPN in human T-cell lymphoma cells involves caspase-dependent and independent pathways. 
  • Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. 
  • Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. 
  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. 
  • Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. 
  • Inhibitor of apoptosis proteins as intracellular signaling intermediates. 
  • Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. 
  • Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells. 
  • Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells. 
  • Intracellular K+ suppresses the activation of apoptosis in lymphocytes. 
  • JCPyV T-Antigen Activation of the Anti-Apoptotic Survivin Promoter-Its Role in the Development of Progressive Multifocal Leukoencephalopathy. 
  • Kupffer cell-derived Fas ligand plays a role in liver injury and hepatocyte death. 
  • Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. 
  • Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock. 
  • Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. 
  • Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts. 
  • Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. 
  • Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. 
  • Mitochondria at the crossroad of apoptotic cell death. 
  • Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. 
  • Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. 
  • Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death. 
  • Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Morphologic features of 115 lymphomas of the orbit and ocular adnexa categorized according to the World Health Organization classification: are marginal zone lymphomas in the orbit mucosa-associated lymphoid tissue-type lymphomas? 
  • NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. 
  • NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. 
  • Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. 
  • Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. 
  • Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. 
  • Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins. 
  • Nitrosative stress-induced apoptosis through inhibition of NF-kappa B. 
  • Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond. 
  • Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. 
  • Optical nanosensors for detecting proteins and biomarkers in individual living cells. 
  • Optical sensor for the detection of caspase-9 activity in a single cell. 
  • Overexpression of caspase-3 in hepatocellular carcinomas. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells. 
  • Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. 
  • Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. 
  • Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease. 
  • Post-cytochrome C protection from apoptosis conferred by a MAPK pathway in Xenopus egg extracts. 
  • Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. 
  • Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia. 
  • Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells. 
  • Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. 
  • Protective effects of resveratrol in experimental retinal detachment. 
  • Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. 
  • Pyroptotic cell death defends against intracellular pathogens. 
  • RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. 
  • Reaper-induced apoptosis in a vertebrate system. 
  • Recent Advances in Lipopolysaccharide Recognition Systems. 
  • Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Regulatory T cell ablation causes acute T cell lymphopenia. 
  • Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. 
  • Role of Caspases and Gasdermin A during HSV-1 Infection in Mice. 
  • SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest. 
  • Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. 
  • Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Senescent fibroblasts resist apoptosis by downregulating caspase-3. 
  • Shigella handcuffs caspases. 
  • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. 
  • Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity. 
  • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. 
  • Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction. 
  • Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells. 
  • T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10. 
  • Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity. 
  • Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. 
  • Tempol therapy attenuates medial smooth muscle cell apoptosis and neointima formation after balloon catheter injury in carotid artery of diabetic rats. 
  • The "cytokine profile": a code for sepsis. 
  • The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast. 
  • The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons. 
  • The IAP proteins: caspase inhibitors and beyond. 
  • The central effectors of cell death in the immune system. 
  • The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus. 
  • The molecular regulation of programmed necrotic cell injury. 
  • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. 
  • The oncogenic microRNA miR-21 promotes regulated necrosis in mice. 
  • The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. 
  • The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. 
  • The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis. 
  • Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. 
  • Upstream regulatory role for XIAP in receptor-mediated apoptosis. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. 
  • Vitamin D(3) cryosensitization increases prostate cancer susceptibility to cryoablation via mitochondrial-mediated apoptosis and necrosis. 
  • Vulnerable windows for developmental ethanol toxicity in the Japanese medaka fish (Oryzias latipes). 
  • WildCARDs: inflammatory caspases directly detect LPS. 
  • Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. 
  • Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1. 
  • X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. 
  • XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. 
  • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. 
  • c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. 
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  Keywords of People

  • Miao, Edward A., Professor of Integrative Immunobiology, Cell Biology