Caspase 1
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Subject Areas on Research
- Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages.
- Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
- Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.
- Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
- Caspase-1-induced pyroptotic cell death.
- Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein.
- Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats.
- Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.
- Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner.
- Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade.
- Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells.
- Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production.
- Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.
- Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
- Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
- Generation of a Listeria vaccine strain by enhanced caspase-1 activation.
- Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
- Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.
- Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea.
- High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays.
- Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA.
- Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.
- IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis.
- Identification of high caspase-3 mRNA expression as a unique signature profile for extremely old individuals.
- Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin.
- Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
- Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
- Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
- Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.
- Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells.
- Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
- Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice.
- Mechanisms of NOD-like receptor-associated inflammasome activation.
- Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.
- NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation.
- NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.
- Pseudomonas aeruginosa activates caspase 1 through Ipaf.
- Pyroptotic cell death defends against intracellular pathogens.
- Reaper-induced apoptosis in a vertebrate system.
- Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.
- The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence.
- The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
- The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection.
- The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair.
- The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury.
- The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells).
- Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
- Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease.
- Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.
- YopM puts caspase-1 on ice.
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Keywords of People
- Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
- Shinohara, Mari L., Associate Professor of Immunology, Immunology