Response Elements

• 

  Subject Areas on Research

  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A combinatorial mechanism for determining the specificity of E2F activation and repression. 
  • A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. 
  • AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). 
  • Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. 
  • Abundant raw material for cis-regulatory evolution in humans. 
  • Activity of a Py-Im polyamide targeted to the estrogen response element. 
  • Allosteric regulation of estrogen receptor structure, function, and coactivator recruitment by different estrogen response elements. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • Auxin 2012: a rich mea ho'oulu. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. 
  • CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. 
  • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. 
  • Cell identity mediates the response of Arabidopsis roots to abiotic stress. 
  • Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells. 
  • Characterization of a putative insulin-responsive element and its binding protein(s) in rat angiotensinogen gene promoter: regulation by glucose and insulin. 
  • Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. 
  • Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis. 
  • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis. 
  • Decoding the language of epigenetics during neural development is key for understanding development as well as developmental neurotoxicity. 
  • Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer. 
  • Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio). 
  • Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants 
  • Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • ELF3 is a repressor of androgen receptor action in prostate cancer cells. 
  • Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. 
  • Evolution: spot on (and off). 
  • FMRP targets distinct mRNA sequence elements to regulate protein expression. 
  • Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer. 
  • Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein. 
  • Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. 
  • Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes. 
  • Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia. 
  • Identification of a novel gene linked to parkin via a bi-directional promoter. 
  • Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. 
  • Increasing the length of poly-pyrimidine bulges broadens RNA conformational ensembles with minimal impact on stacking energetics. 
  • Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. 
  • Influence of dimethylsulfoxide on RNA structure and ligand binding. 
  • Inter-helical conformational preferences of HIV-1 TAR-RNA from maximum occurrence analysis of NMR data and molecular dynamics simulations. 
  • Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation. 
  • LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. 
  • Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium. 
  • Landscape of stimulation-responsive chromatin across diverse human immune cells. 
  • Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer. 
  • Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. 
  • Ligand-specific dynamics of the androgen receptor at its response element in living cells. 
  • Live-cell Measurement of Odorant Receptor Activation Using a Real-time cAMP Assay. 
  • Mutational processes in cancer preferentially affect binding of particular transcription factors. 
  • Nrf2, a multi-organ protector? 
  • Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis. 
  • Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression. 
  • Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis. 
  • Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. 
  • Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. 
  • Probing Na(+)-induced changes in the HIV-1 TAR conformational dynamics using NMR residual dipolar couplings: new insights into the role of counterions and electrostatic interactions in adaptive recognition. 
  • Probing motions between equivalent RNA domains using magnetic field induced residual dipolar couplings: accounting for correlations between motions and alignment. 
  • RB regulates transcription of the p21/WAF1/CIP1 gene. 
  • ROR alpha augments thyroid hormone receptor-mediated transcriptional activation. 
  • Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release. 
  • Reactivation of Epstein-Barr Virus by HIF-1α Requires p53. 
  • Redox regulation of the rat hepatocyte iNOS promoter. 
  • Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. 
  • Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes. 
  • Slowdown of Interhelical Motions Induces a Glass Transition in RNA. 
  • Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation. 
  • Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. 
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. 
  • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. 
  • The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. 
  • The homeodomain protein HOXB13 regulates the cellular response to androgens. 
  • The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes. 
  • The negative side of retinoic acid receptors. 
  • The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. 
  • The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. 
  • The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. 
  • Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation. 
  • Thyroid hormones and 3,5-diiodothyropropionic acid: new keys for new locks. 
  • Transcription of the RelB gene is regulated by NF-kappaB. 
  • Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation. 
  • Transgenic ω-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins. 
  • Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. 
  • cis element/transcription factor analysis (cis/TF): a method for discovering transcription factor/cis element relationships. 
  • m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB. 
  • microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. 
  • p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription. 
• 

  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology