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Subject Areas on Research
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A 26-year-old man with severe right ventricular hypertrophy.
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A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish.
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A critical review of hemodynamic changes and left ventricular remodeling after surgical aortic valve replacement and percutaneous aortic valve replacement.
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A randomized, double-blind, placebo-controlled trial to evaluate the safety and effectiveness of intracoronary application of a novel bioabsorbable cardiac matrix for the prevention of ventricular remodeling after large ST-segment elevation myocardial infarction: Rationale and design of the PRESERVATION I trial.
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Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial.
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Age Differences in Effects of Sacubitril/Valsartan on Cardiac Remodeling, Biomarkers, and Health Status.
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Analysis of ventricular activation using surface electrocardiography to predict left ventricular reverse volumetric remodeling during cardiac resynchronization therapy.
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Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction.
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Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Left Ventricular Hypertrophy: Insights From the ARISTOTLE Trial.
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Apolipoprotein E Polymorphism, Cardiac Remodeling, and Heart Failure in the ARIC Study.
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Assessment of no-reflow regions using cardiac MRI.
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Association Between Angiotensin Receptor-Neprilysin Inhibition, Cardiovascular Biomarkers, and Cardiac Remodeling in Heart Failure With Reduced Ejection Fraction.
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Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects.
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Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.
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Benefit of cardiopoietic mesenchymal stem cell therapy on left ventricular remodelling: results from the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) study.
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Beyond fitness tracking: The use of consumer-grade wearable data from normal volunteers in cardiovascular and lipidomics research.
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Bioabsorbable Intracoronary Matrix for Prevention of Ventricular Remodeling After Myocardial Infarction.
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Biomarkers, mineralocorticoid receptor antagonism, and cardiorenal remodeling.
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Branch Pulmonary Artery Valve Implantation Reduces Pulmonary Regurgitation and Improves Right Ventricular Size/Function in Patients With Large Right Ventricular Outflow Tracts.
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Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?
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Calcific Aortic Valve Disease: Part 2-Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility.
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Cardiac Myosin Activator Omecamtiv Mecarbil Improves Left Ventricular Myocardial Deformation in Chronic Heart Failure: The COSMIC-HF Trial.
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Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.
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Cardiac remodeling after large ST-elevation myocardial infarction in the current therapeutic era.
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Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.
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Cell size and communication: role in structural and electrical development and remodeling of the heart.
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Central sympathetic blockade ameliorates brain death-induced cardiotoxicity and associated changes in myocardial gene expression.
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Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial.
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Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part 1: Clinical Trial Design Principles: A Consensus Document From the Mitral Valve Academic Research Consortium.
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Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 1: Pluridisciplinary perspective on their hemodynamics and morphomechanics.
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Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.
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Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling.
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Controversies and Challenges of Ventricular Assist Device Therapy.
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Coronary bypass surgery with or without surgical ventricular reconstruction.
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Cross-sectional relations of lipid concentrations to left ventricular structural attributes.
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Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.
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Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial.
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Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice.
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Dose-Response to Sacubitril/Valsartan in Patients With Heart Failure and Reduced Ejection Fraction.
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Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling.
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Effects of amino acid supplementation on left ventricular remodeling in patients with chronic heart failure with decreased systolic function and diabetes mellitus: rationale and design of a magnetic resonance imaging study.
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Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial.
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Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction-Results of the Chymase Inhibitor in Adverse Remodeling after Myocardial Infarction (CHIARA MIA) 2 trial.
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Electrical pacing counteracts intrinsic shortening of action potential duration of neonatal rat ventricular cells in culture.
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Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth.
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Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach.
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Emerging Therapies for Congestive Heart Failure.
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Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.
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Epicardial Surface Area of Infarction: A Stable Surrogate of Microvascular Obstruction in Acute Myocardial Infarction.
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Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling.
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Evaluation of right and left ventricular diastolic filling.
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FGF23 and Left Ventricular Hypertrophy in Children with CKD.
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FGF23 modifies the relationship between vitamin D and cardiac remodeling.
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Familial aggregation of left ventricular geometry and association with parental heart failure: the Framingham Heart Study.
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Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart.
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Fluid dynamics of ventricular filling in heart failure: overlooked problems of RV/LV chamber dilatation.
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Functional assessment of myoblast transplantation for cardiac repair with magnetic resonance imaging.
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G-Protein-Coupled Receptors in Heart Disease.
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Gadolinium cardiovascular magnetic resonance predicts reversible myocardial dysfunction and remodeling in patients with heart failure undergoing beta-blocker therapy.
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Gender differences in molecular remodeling in pressure overload hypertrophy.
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Gender differences in postinfarction left ventricular remodeling.
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Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.
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Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.
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Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium.
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Genomics and the pathophysiology of heart failure.
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Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
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Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
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HFE H63D Polymorphism and the Risk for Systemic Hypertension, Myocardial Remodeling, and Adverse Cardiovascular Events in the ARIC Study.
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Heart Failure Duration and Mechanistic Efficacy of Sacubitril/Valsartan in Heart Failure With Reduced Ejection Fraction.
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Heart Failure and Atrial Fibrillation, Like Fire and Fury.
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Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ventricular function.
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High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT.
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High-risk percutaneous coronary intervention is associated with reverse left ventricular remodeling and improved outcomes in patients with coronary artery disease and reduced ejection fraction.
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Impact of Non-Infarct-Related Artery Disease on Infarct Size and Outcomes (from the CRISP-AMI Trial).
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Impact of Physiologic Pacing Versus Right Ventricular Pacing Among Patients With Left Ventricular Ejection Fraction Greater Than 35%: A Systematic Review for the 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.
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Impact of physiologic pacing versus right ventricular pacing among patients with left ventricular ejection fraction greater than 35%: A systematic review for the 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.
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Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction.
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Implications of Left Ventricular Geometry in Low-Flow Aortic Stenosis: A PARTNER 2 Trial Subanalysis.
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Improved left ventricular mass quantification with partial voxel interpolation: in vivo and necropsy validation of a novel cardiac MRI segmentation algorithm.
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Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.
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Incremental prognostic value of echocardiography of left ventricular remodeling and diastolic function in STICH trial.
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Infarct healing is a dynamic process following acute myocardial infarction.
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Infarct resorption, compensatory hypertrophy, and differing patterns of ventricular remodeling following myocardial infarctions of varying size.
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Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy.
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Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.
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Inhibition of the cardiomyocyte-specific troponin I-interacting kinase limits oxidative stress, injury, and adverse remodeling due to ischemic heart disease.
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Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice.
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Insights from the STICH trial: change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction.
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Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling.
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Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial.
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Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling.
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Klotho and phosphate are modulators of pathologic uremic cardiac remodeling.
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Lack of Thy1 defines a pathogenic fraction of cardiac fibroblasts in heart failure.
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Left Ventricular Hypertrophy Does Not Affect 1-Year Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement.
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Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR: An Analysis of the PARTNER Trials and Registries.
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Left bundle branch block-induced left ventricular remodeling and its potential for reverse remodeling.
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Left ventricular dysfunction: causes, natural history, and hopes for reversal.
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Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure.
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Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis.
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MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
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Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy.
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Measures of cardiac repolarization and body position in infants.
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Mechanisms and Models in Heart Failure: A Translational Approach.
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Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: part 1.
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Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice.
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Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure.
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Mitral-valve repair versus replacement for severe ischemic mitral regurgitation.
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Monocytes prime autoreactive T cells after myocardial infarction.
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Myocardial Damage Detected by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Uncommon in Peripartum Cardiomyopathy.
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Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.
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NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF.
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Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level.
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New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics.
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Novel role of platelet reactivity in adverse left ventricular remodelling after ST-segment elevation myocardial infarction: The REMODELING Trial.
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Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II: rationale and design of the ORBIT-AF II registry.
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Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction.
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PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.
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Patterns of left ventricular remodeling in patients with Duchenne Muscular Dystrophy: a cardiac MRI study of ventricular geometry, global function, and strain.
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Percutaneous mitral valve repair in the initial EVEREST cohort: evidence of reverse left ventricular remodeling.
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Platelet inhibition to target reperfusion injury trial: Rationale and study design.
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Predicting chronic left ventricular dysfunction 90 days after ST-segment elevation myocardial infarction: An Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Substudy.
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Predictors of mortality and outcomes of therapy in low-flow severe aortic stenosis: a Placement of Aortic Transcatheter Valves (PARTNER) trial analysis.
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Prognostic importance of pathophysiologic markers in patients with heart failure and preserved ejection fraction.
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Prognostic value of left ventricular apical tissue removed for HeartMate II left ventricular assist device placement.
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Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events.
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QRS fusion complex analysis using wave interference to predict reverse remodeling during cardiac resynchronization therapy.
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Racial and Ethnic Differences in Biomarkers, Health Status, and Cardiac Remodeling in Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan.
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Racial/Ethnic Differences in Left Ventricular Structure and Function in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort.
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Rationale and design of a randomized controlled trial of allogeneic mesenchymal stem cells in patients with nonischemic cardiomyopathy.
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Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure.
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Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling.
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Regional left ventricular function does not predict survival in ischaemic cardiomyopathy after cardiac surgery.
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Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure.
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Relationship between galectin-3 levels and mineralocorticoid receptor antagonist use in heart failure: analysis from HF-ACTION.
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Relationship between the magnitude of reduction in mitral regurgitation severity and left ventricular and left atrial reverse remodeling after MitraClip therapy.
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Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle.
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Retinal arteriolar narrowing and left ventricular remodeling: the multi-ethnic study of atherosclerosis.
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Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.
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Reverse Cardiac Remodeling Following Initiation of Sacubitril/Valsartan in Patients With Heart Failure With and Without Diabetes.
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Reverse Cardiac Remodeling and Outcome After Initiation of Sacubitril/Valsartan.
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Right ventricular lead location and outcomes among patients with cardiac resynchronization therapy: A meta-analysis.
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Right-Sided Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction and Worsening Renal Function.
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Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction.
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SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.
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Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.
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Secondary mitral and tricuspid regurgitation accompanying left ventricular systolic dysfunction: is it important, and how is it treated?
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Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization.
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Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload.
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Sex-Based Differences in Outcomes After Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network.
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Sex-based differences in biomarkers, health status, and reverse cardiac remodelling in patients with heart failure with reduced ejection fraction treated with sacubitril/valsartan.
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Simple regional strain pattern analysis to predict response to cardiac resynchronization therapy: rationale, initial results, and advantages.
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Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice.
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Sodium-Glucose Cotransporter 2 Inhibitors and Cardiac Remodeling.
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Strategies to attenuate pathological remodeling in heart failure.
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Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies.
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Surgical treatment of moderate ischemic mitral regurgitation.
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Surrogate end points in heart failure trials.
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Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice.
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TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
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Targeted anti-IL-1β platelet microparticles for cardiac detoxing and repair.
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Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.
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The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle.
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The PARACHUTE IV trial design and rationale: percutaneous ventricular restoration using the parachute device in patients with ischemic heart failure and dilated left ventricles.
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The Role for Cardiovascular Remodeling in Cardiovascular Outcomes.
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The STICH trial: evidence-based conclusions.
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The association between biventricular pacing and cardiac resynchronization therapy-defibrillator efficacy when compared with implantable cardioverter defibrillator on outcomes and reverse remodelling.
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The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.
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The continuous heart failure spectrum: moving beyond an ejection fraction classification.
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The elusive philosopher's stone in young blood.
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The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
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The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.
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The nitric oxide donor S-nitroso-N-acetylpenicillamine (SNAP) increases free radical generation and degrades left ventricular function after myocardial ischemia-reperfusion.
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The perplexing complexity of cardiac arrhythmias: beyond electrical remodeling.
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The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature.
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The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury.
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Thrombogenesis in atrial fibrillation: contributing mechanisms and natural history.
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Transthyretin V142I Genetic Variant and Cardiac Remodeling, Injury, and Heart Failure Risk in Black Adults.
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Treatment of functional mitral valve regurgitation with the permanent percutaneous transvenous mitral annuloplasty system: results of the multicenter international Percutaneous Transvenous Mitral Annuloplasty System to Reduce Mitral Valve Regurgitation in Patients with Heart Failure trial.
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Treatment of sleep-disordered breathing in heart failure impacts cardiac remodeling: Insights from the CAT-HF Trial.
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Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation.
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Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation.
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Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial.
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Vectorcardiographic QRS area is associated with long-term outcome after cardiac resynchronization therapy.
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YAP: The nexus between metabolism and cardiac remodeling.
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β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction.
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Keywords of People
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Badea, Cristian Tudorel,
Professor in Radiology,
Biomedical Engineering
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Landstrom, Andrew Paul,
Associate Professor of Pediatrics,
Cell Biology
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Mentz, Robert John,
Associate Professor of Medicine,
Medicine, Cardiology
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Milano, Carmelo Alessio,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Surgery, Cardiovascular and Thoracic Surgery
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Milazzo Jr., Angelo Stephen,
Professor of Pediatrics,
Pediatrics
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O'Connor, Christopher Michael,
Richard Sean Stack, M.D. Distinguished Professor,
Medicine, Clinical Pharmacology