Neurotoxicity Syndromes

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  Subject Areas on Research

  • A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research. 
  • Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. 
  • An expert-driven literature review of "negative" chemicals for developmental neurotoxicity (DNT) in vitro assay evaluation. 
  • Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy. 
  • Baclofen Toxicity in Kidney Disease. 
  • Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. 
  • Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • Central nervous system toxicity following the administration of levobupivacaine for lumbar plexus block: A report of two cases. 
  • Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data. 
  • Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. 
  • Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. 
  • Clinical and Imaging Features of Contrast-Induced Neurotoxicity After Neurointerventional Surgery. 
  • Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. 
  • Concerning "Absence of neurotoxicity with medicinal grade terbutaline in the rat model," by M.Y. Owens, K.L. Wallace, N. Mamoon, J. Wyatt-Ashmead and W.A. Bennett. 
  • Continuing education course #1: non-invasive imaging as a problem-solving tool and translational biomarker strategy in toxicologic pathology. 
  • Continuing education course #3: current practices and future trends in neuropathology assessment for developmental neurotoxicity testing. 
  • Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats. 
  • Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. 
  • Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine. 
  • Developmental diazinon neurotoxicity in rats: later effects on emotional response. 
  • Developmental exposure of zebrafish to vitamin D receptor acting drugs and environmental toxicants disrupts behavioral function. 
  • Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. 
  • Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood. 
  • Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro. 
  • Developmental neurotoxicity of parathion: progressive effects on serotonergic systems in adolescence and adulthood. 
  • Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. 
  • Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. 
  • Diverse neurotoxicants target the differentiation of embryonic neural stem cells into neuronal and glial phenotypes. 
  • Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence? 
  • Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos? 
  • Evaluation of thiamine for the prevention of ifosfamide-induced encephalopathy. 
  • From molecular mechanisms to functional impact: Developing integrated analyses in neurotoxicology - The 16th biennial meeting International Neurotoxicology Association and 8th meeting of the NeuroToxicity Society. 
  • Gene-environment interactions: neurodegeneration in non-mammals and mammals. 
  • Genetic aspects of behavioral neurotoxicology. 
  • Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. 
  • Human health effects of exposure to Pfiesteria piscicida: a review. 
  • In Response. 
  • Induction of Neuroinflammation and Neurotoxicity by Synthetic Hemozoin. 
  • Introduction to sex differences in neurotoxic effects. 
  • Is Metal-On-Metal Total Hip Arthroplasty Associated With Neurotoxicity? 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • Neurobehavioral effects of chronic dietary and repeated high-level spike exposure to chlorpyrifos in rats. 
  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model. 
  • Neuroimaging: strategies to illuminate environment-disease linkages. Session II. Summary and research needs. 
  • Neurotoxicity associated with suspected southern Pacific rattlesnake (Crotalus viridis helleri) envenomation. 
  • Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. 
  • Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity. 
  • Oral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicity. 
  • Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. 
  • Perioperative neurotoxicity in the elderly: summary of the 4th International Workshop. 
  • Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. 
  • Prenatal dexamethasone augments the sex-selective developmental neurotoxicity of chlorpyrifos: implications for vulnerability after pharmacotherapy for preterm labor. 
  • Prolonged oxaliplatin exposure alters intracellular calcium signaling: a new mechanism to explain oxaliplatin-associated peripheral neuropathy. 
  • Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. 
  • Sea urchin embryonic development provides a model for evaluating therapies against beta-amyloid toxicity. 
  • Sea urchin embryos and larvae as biosensors for neurotoxicants. 
  • The outdoor air pollution and brain health workshop. 
  • The preferences of women with ovarian cancer for oral versus intravenous recurrence regimens. 
  • The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine. 
  • Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. 
  • Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. 
  • Virtual neuropathology: three-dimensional visualization of lesions due to toxic insult. 
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  Keywords of People

  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology