In Situ Nick-End Labeling

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  Subject Areas on Research

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. 
  • A clinically relevant model of perinatal global ischemic brain damage in rats. 
  • A high-throughput histoarray for quantitative molecular profiling of multiple, uniformly oriented medaka (Oryzias latipes) embryos. 
  • A novel protective effect of erythropoietin in the infarcted heart. 
  • Adenovirus-mediated delivery of catalase to retinal pigment epithelial cells protects neighboring photoreceptors from photo-oxidative stress. 
  • Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]. 
  • Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice. 
  • Apoptosis during coronary artery orifice development in the chick embryo. 
  • Apoptosis in the chorion laeve of term patients with histologic chorioamnionitis. 
  • Apoptosis in the chorion of fetal membranes in preterm premature rupture of membranes. 
  • Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • Basal cell hyperplasia in the peripheral zone of the prostate. 
  • Bcl-2 accelerates multistep prostate carcinogenesis in vivo. 
  • Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study. 
  • Biological function and mechanism of miR-33a in prostate cancer survival and metastasis: via downregulating Engrailed-2. 
  • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. 
  • Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung. 
  • CD10/neutral endopeptidase inhibition augments pulmonary neuroendocrine cell hyperplasia in hamsters treated with diethylnitrosamine and hyperoxia. 
  • CDB-4124 does not cause apoptosis in cultured fibroid cells. 
  • Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. 
  • Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. 
  • Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. 
  • Cardioprotective effects of erythropoietin in the reperfused ischemic heart: a potential role for cardiac fibroblasts. 
  • Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. 
  • Cholestyramine feeding lowers number of colonic apoptotic cells in rat. 
  • Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi. 
  • Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1. 
  • Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival? 
  • Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin. 
  • Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. 
  • Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. 
  • Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice. 
  • Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. 
  • Enhanced H(2)O(2)-induced cytotoxicity in "epithelioid" smooth muscle cells: implications for neointimal regression. 
  • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis. 
  • Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. 
  • Gamma radiation-induced apoptosis, G2 delay, and the risk of salivary and thyroid carcinomas--a preliminary report. 
  • General anesthesia improves fetal cerebral oxygenation without evidence of subsequent neuronal injury. 
  • HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue. 
  • Increased expression of ceruloplasmin in the retina following photic injury. 
  • Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum. 
  • Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. 
  • JNK1 is required to preserve cardiac function in the early response to pressure overload. 
  • Lack of apoptosis in the hypoxic brain of a rat model mimicking cyanotic heart disease. 
  • Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. 
  • Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. 
  • Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. 
  • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. 
  • NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. 
  • Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. 
  • Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain. 
  • Neurotrophin-3 mediates the autocrine survival of the catecholaminergic CAD CNS neuronal cell line. 
  • Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. 
  • Nrf2-mediated protection against 6-hydroxydopamine. 
  • Overexpression of caspase-3 in hepatocellular carcinomas. 
  • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. 
  • PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. 
  • Patterns of cell signaling pathway activation that characterize mammary development. 
  • Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis. 
  • Persistent fetal ocular vasculature in mice deficient in bax and bak. 
  • Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. 
  • Piezo-assisted nuclear transfer affects cloning efficiency and may cause apoptosis. 
  • Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. 
  • Preclinical evidence for therapeutic efficacy of selective estrogen receptor modulators for uterine leiomyoma. 
  • Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis. 
  • Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms. 
  • Quantifiable biomarkers of normal aging in the Japanese medaka fish (Oryzias latipes). 
  • Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors. 
  • RGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysis. 
  • Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity. 
  • Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. 
  • Restriction of hepatic competence by Fgf signaling. 
  • Role of the Fas-signaling pathway in photoreceptor neuroprotection. 
  • Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. 
  • Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine. 
  • Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model. 
  • Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. 
  • Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats. 
  • Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina. 
  • Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. 
  • Targeting A20 decreases glioma stem cell survival and tumor growth. 
  • Targeting the Tie2/Tek receptor in astrocytomas. 
  • Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. 
  • Tea consumption, apoptosis, and colorectal adenomas. 
  • The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression. 
  • The adherens junction-associated protein 1 is a negative transcriptional regulator of MAGEA2, which potentiates temozolomide-induced apoptosis in GBM. 
  • The effect of dexamethasone on the generation of plasma DNA from dead and dying cells. 
  • The exon junction complex component Magoh controls brain size by regulating neural stem cell division. 
  • The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells. 
  • The role of surfactant protein A in bleomycin-induced acute lung injury. 
  • The zinc finger transcription factor ZFX is required for maintaining the tumorigenic potential of glioblastoma stem cells. 
  • Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. 
  • Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. 
  • Trophic effects of androgen: development and hormonal regulation of neuron number in a sexually dimorphic vocal motor nucleus. 
  • Viability and apoptosis of human chondrocytes in osteochondral fragments following joint trauma. 
  • Wnt4 is essential to normal mammalian lung development. 
  • mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.