Surface Plasmon Resonance

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  Subject Areas on Research

  • A new method for studying the interaction between chlorpromazine and phospholipid bilayer. 
  • A novel antibody humanization method based on epitopes scanning and molecular dynamics simulation. 
  • Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas. 
  • Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas. 
  • Aluminum nanocrystals. 
  • Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. 
  • Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors. 
  • Angle-dependent resonance of localized and propagating surface plasmons in microhole arrays for enhanced biosensing. 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Assembly and molecular activities of the MutS tetramer. 
  • Assembly of alternating polycation and DNA multilayer films by electrostatic layer-by-layer adsorption. 
  • Beta2-glycoprotein I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of beta2-glycoprotein I. 
  • Bimodal behavior and isobestic transition pathway in surface plasmon resonance sensing. 
  • Bioplasmonic calligraphy for multiplexed label-free biodetection. 
  • Bioplasmonic paper as a platform for detection of kidney cancer biomarkers. 
  • Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial. 
  • CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. 
  • Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action. 
  • Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread. 
  • Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. 
  • Characterization of host-cell line specific glycosylation profiles of early transmitted/founder HIV-1 gp120 envelope proteins. 
  • Characterization of non-equilibrium nanoparticle adsorption on a model biological substrate. 
  • Chemical synthesis of novel plasmonic nanoparticles. 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Cold sensitivity of the SARS-CoV-2 spike ectodomain. 
  • Colloidal Synthesis of Nanopatch Antennas for Applications in Plasmonics and Nanophotonics. 
  • Comparison of FDTD numerical computations and analytical multipole expansion method for plasmonics-active nanosphere dimers. 
  • Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold. 
  • Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy. 
  • Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens. 
  • Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins. 
  • Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. 
  • DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes. 
  • Deep UV nano-microstructuring of substrates for surface plasmon resonance imaging. 
  • Design of a calcium-binding protein with desired structure in a cell adhesion molecule. 
  • Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Direct Coupling of Plasmonic and Photonic Nanowires for Hybrid Nanophotonic Components and Circuits 
  • Direct and Label-Free Detection of MicroRNA Cancer Biomarkers using SERS-Based Plasmonic Coupling Interference (PCI) Nanoprobes. 
  • Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis. 
  • Dual-order snapshot spectral imaging of plasmonic nanoparticles. 
  • Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity? 
  • Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. 
  • Enhancing four-wave-mixing processes by nanowire arrays coupled to a gold film. 
  • Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. 
  • Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody. 
  • Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays. 
  • Enzymatically Degassed Surface-Initiated Atom Transfer Radical Polymerization with Real-Time Monitoring. 
  • Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. 
  • Fabrication of surface plasmon resonators by nanoskiving single-crystalline gold microplates. 
  • Fano resonance in a gold nanosphere with a J-aggregate coating. 
  • Far-field analysis of axially symmetric three-dimensional directional cloaks. 
  • Functional roles of the two domains of phosducin and phosducin-like protein. 
  • GaMg alloy nanoparticles for broadly tunable plasmonics. 
  • Gold Nanorod Size-Dependent Fluorescence Enhancement for Ultrasensitive Fluoroimmunoassays. 
  • Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. 
  • H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. 
  • Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites. 
  • High-throughput affinity ranking of antibodies using surface plasmon resonance microarrays. 
  • Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. 
  • Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state. 
  • Immunotoxins with increased activity against epidermal growth factor receptor vIII-expressing cells produced by antibody phage display. 
  • In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars. 
  • Inherently stealthy and highly tumor-selective gold nanoraspberries for photothermal cancer therapy. 
  • Interfacial phase transition of an environmentally responsive elastin biopolymer adsorbed on functionalized gold nanoparticles studied by colloidal surface plasmon resonance. 
  • Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting. 
  • Isolation of novel EGFR-specific VHH domains. 
  • Label free colorimetric biosensing using nanoparticles. 
  • Label-free biosensing by surface plasmon resonance of nanoparticles on glass: optimization of nanoparticle size. 
  • Label-free plasmonic detection of biomolecular binding by a single gold nanorod. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • Measurement of cell migration on surface-bound fibronectin gradients. 
  • Measuring morphological features using light-scattering spectroscopy and Fourier-domain low-coherence interferometry. 
  • Megalin mediates renal uptake of heavy metal metallothionein complexes. 
  • Metallic nanoparticle arrays: a common substrate for both surface-enhanced Raman scattering and surface-enhanced infrared absorption. 
  • Mid-IR plasmonics: near-field imaging of coherent plasmon modes of silver nanowires. 
  • Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors. 
  • Narrow groove plasmonic nano-gratings for surface plasmon resonance sensing. 
  • Observation of plasmon propagation, redirection, and fan-out in silver nanowires. 
  • Optical near-field mapping of plasmonic nanoprisms. 
  • Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices. 
  • Plasmon ruler with angstrom length resolution. 
  • Plasmonic Luneburg and Eaton lenses. 
  • Plasmonic detection of a model analyte in serum by a gold nanorod sensor. 
  • Plasmonic multi-mode interference couplers. 
  • Plasmonic nanoprobes for intracellular sensing and imaging. 
  • Plasmonic waveguide modes of film-coupled metallic nanocubes. 
  • Plasmonics enhancement of a luminescent or Raman-active layer in a multilayered metallic nanoshell. 
  • Plasmonics-based SERS nanobiosensor for homogeneous nucleic acid detection. 
  • Precise Colloidal Plasmonic Photocatalysts Constructed by Multistep Photodepositions. 
  • Probing dynamically tunable localized surface plasmon resonances of film-coupled nanoparticles by evanescent wave excitation. 
  • Probing the ultimate limits of plasmonic enhancement. 
  • Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. 
  • Quantification of the binding affinity of a specific hydroxyapatite binding peptide. 
  • Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity. 
  • Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. 
  • Quintuple-modality (SERS-MRI-CT-TPL-PTT) plasmonic nanoprobe for theranostics. 
  • Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systems. 
  • Rapid kinetic-based screening of human Fab fragments. 
  • Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis. 
  • Rational selection of gold nanorod geometry for label-free plasmonic biosensors. 
  • Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. 
  • Reconfigurable Chirality of DNA-Bridged Nanorod Dimers. 
  • Reconfigurable core-satellite nanoassemblies as molecularly-driven plasmonic switches 
  • Screening the interactions between HIV-1 neutralizing antibodies and model lipid surfaces. 
  • Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies. 
  • Self-orienting nanocubes for the assembly of plasmonic nanojunctions. 
  • Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability. 
  • Simulation of complex plasmonic circuits including bends. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Size-dependence of surface plasmon resonance and oxidation for Pd nanocubes synthesized via a seed etching process. 
  • Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli. 
  • Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant. 
  • Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein. 
  • Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions. 
  • Streptavidin binding and endothelial cell adhesion to biotinylated fibronectin. 
  • Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1. 
  • Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex. 
  • Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen. 
  • Surface-initiated enzymatic polymerization of DNA. 
  • Synthesis and optical properties of silver nanobars and nanorice. 
  • Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. 
  • The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. 
  • The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF 
  • The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. 
  • The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. 
  • Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. 
  • Tunable and amplified Raman gold nanoprobes for effective tracking (TARGET): in vivo sensing and imaging. 
  • Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry. 
  • Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays. 
  • Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1). 
  • Ultraviolet surface-enhanced Raman scattering at the plasmonic band edge of a metallic grating. 
  • Using microcantilever deflection to detect HIV-1 envelope glycoprotein gp120. 
  • Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Jokerst, Nan Marie, J. A. Jones Distinguished Professor of Electrical and Computer Engineering, Nicholas Institute-Energy Initiative
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Wax, Adam P., Professor of Biomedical Engineering, Biomedical Engineering