Osteoarthritis, Knee

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  Subject Areas on Research

  • "I Could Do It in My Own Time and When I Really Needed It": Perceptions of Online Pain Coping Skills Training For People With Knee Osteoarthritis. 
  • A "best-in-class" systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression. 
  • A Bayesian missing data framework for generalized multiple outcome mixed treatment comparisons. 
  • A Case Complexity Modifier Is Warranted for Primary Total Knee Arthroplasty. 
  • A Combined Patient and Provider Intervention for Management of Osteoarthritis in Veterans: A Randomized Clinical Trial. 
  • A comparative assessment of alignment angle of the knee by radiographic and physical examination methods. 
  • A comparison of five approaches to measurement of anatomic knee alignment from radiographs. 
  • A comparison of subvastus and midvastus approaches in minimally invasive total knee arthroplasty. 
  • A comparison of the midvastus and paramedian approaches for total knee arthroplasty. 
  • A comprehensive review of the effectiveness of different exercise programs for patients with osteoarthritis. 
  • A consensus-based framework for conducting and reporting osteoarthritis phenotype research. 
  • A kinetic and kinematic analysis of the effect of stochastic resonance electrical stimulation and knee sleeve during gait in osteoarthritis of the knee. 
  • A large kindred of early-onset osteoarthritis of the knee and hip: excluding the link to COL2A1 gene. 
  • A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis. 
  • A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis. 
  • A multicenter randomised, 1-year comparative effectiveness, parallel-group trial protocol of a physical therapy approach compared to corticosteroid injection on pain and function related to knee osteoarthritis (PTA Trial). 
  • A physiotherapist-delivered integrated exercise and pain coping skills training intervention for individuals with knee osteoarthritis: a randomised controlled trial protocol. 
  • A physiotherapist-delivered, combined exercise and pain coping skills training intervention for individuals with knee osteoarthritis: a pilot study. 
  • A pilot cluster-randomized trial of a 20-week Tai Chi program in elders with cognitive impairment and osteoarthritic knee: effects on pain and other health outcomes. 
  • A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. 
  • A supplemental report to a randomized cluster trial of a 20-week Sun-style Tai Chi for osteoarthritic knee pain in elders with cognitive impairment. 
  • A theory of planned behavior-based intervention to improve quality of life in patients with knee/hip osteoarthritis: a randomized controlled trial. 
  • AAOS Technology Overview Summary: Concentrated Bone Marrow Aspirate for Knee Osteoarthritis. 
  • Accelerometer-Based Physical Activity Patterns and Associations With Outcomes Among Individuals With Osteoarthritis. 
  • Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. 
  • Acute Intervention With Selective Interleukin-1 Inhibitor Therapy May Reduce the Progression of Posttraumatic Osteoarthritis of the Knee: A Systematic Review of Current Evidence. 
  • Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. 
  • Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis. 
  • Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages. 
  • An ACS-NSQIP Analysis of Unicompartmental Knee Arthroplasty Trends from 2013 to 2018. 
  • Analysis of procedure-related costs and proposed benefits of using patient-specific approach in total knee arthroplasty. 
  • Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells. 
  • Application of Heterogeneity of Treatment-Effects Methods: Exploratory Analyses of a Trial of Exercise-Based Interventions for Knee Osteoarthritis. 
  • Application of Traditional and Emerging Methods for the Joint Analysis of Repeated Measurements With Time-to-Event Outcomes in Rheumatology. 
  • Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain. 
  • Arthroscopic partial meniscectomy was not more effective than physical therapy for meniscal tear and knee osteoarthritis. 
  • Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines. 
  • Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. 
  • Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage. 
  • Assessing Lower Limb Alignment: Comparison of Standard Knee Xray vs Long Leg View. 
  • Association Between Biochemical Markers of Bone Turnover and Bone Changes on Imaging: Data From the Osteoarthritis Initiative. 
  • Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study. 
  • Association between metabolic syndrome, radiographic knee osteoarthritis, and intensity of knee pain: results of a national survey. 
  • Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. 
  • Association of bone scintigraphic abnormalities with knee malalignment and pain. 
  • Association of chemokine expression in anterior cruciate ligament deficient knee with patient characteristics: Implications for post-traumatic osteoarthritis. 
  • Association of knee and ankle osteoarthritis with physical performance. 
  • Associations Between Fat Mass, Lean Mass, and Knee Osteoarthritis: The Fifth Korean National Health and Nutrition Examination Survey (KNHANES V). 
  • Associations between pressure-pain threshold, symptoms, and radiographic knee and hip osteoarthritis. 
  • Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project. 
  • Associations of occupational tasks with knee and hip osteoarthritis: the Johnston County Osteoarthritis Project. 
  • Automatic atlas-based three-label cartilage segmentation from MR knee images. 
  • Better Knee, Better Me™: effectiveness of two scalable health care interventions supporting self-management for knee osteoarthritis - protocol for a randomized controlled trial. 
  • Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms? 
  • Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial. 
  • Blood in the joint: effects of hemarthrosis on meniscus health and repair techniques. 
  • Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation. 
  • Brief Fear of Movement Scale for osteoarthritis. 
  • Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. 
  • Can Patient-Reported Outcome Measurement Information System Measures Differentiate Patients Who Will Undergo Hip and Knee Total Joint Arthroplasty: A Retrospective Case-Control Study. 
  • Can physical therapists deliver a pain coping skills program? An examination of training processes and outcomes. 
  • Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing. 
  • Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography. 
  • Changes in functional status among persons over age sixty-five undergoing total knee arthroplasty. 
  • Characterization of a consistent radiographic finding in chronic anterior cruciate ligament deficiency: the posteromedial osteophyte. 
  • Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules. 
  • Clinic variation in recruitment metrics, patient characteristics and treatment use in a randomized clinical trial of osteoarthritis management. 
  • Clinical hip tests and a functional squat test in patients with knee osteoarthritis: reliability, prevalence of positive test findings, and short-term response to hip mobilization. 
  • Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis. 
  • Cognitive Mediators of Change in Physical Functioning in Response to a Multifaceted Intervention for Managing Osteoarthritis. 
  • Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial. 
  • Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial. 
  • Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis. 
  • Comparison of the ACL and ACL graft forces before and after ACL reconstruction: an in-vitro robotic investigation. 
  • Complications of osteotomies about the knee. 
  • Composite measures of physical activity and pain associate better with functional assessments than pain alone in knee osteoarthritis. 
  • Computer navigation-assisted versus minimally invasive TKA: benefits and drawbacks. 
  • Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice. 
  • Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease. 
  • Correlation of knee and hindfoot deformities in advanced knee OA: compensatory hindfoot alignment and where it occurs. 
  • Correlation of pre-operative planning to surgical correction of opening wedge HTO: a radiographic study utilizing a manual measurement method. 
  • Cost and Quality of Life Outcomes of the STepped Exercise Program for Patients With Knee OsteoArthritis Trial. 
  • Cost-Effectiveness Analysis of Early Reconstruction Versus Rehabilitation and Delayed Reconstruction for Anterior Cruciate Ligament Tears. 
  • Cost-effectiveness of Physical Therapy vs Intra-articular Glucocorticoid Injection for Knee Osteoarthritis: A Secondary Analysis From a Randomized Clinical Trial. 
  • Cost-effectiveness of physical activity and exercise therapy programs for knee osteoarthritis: making the case for health plan coverage. 
  • Current strategies for nonsurgical, arthroscopic, and minimally invasive surgical treatment of knee cartilage pathology. 
  • Daily spousal influence on physical activity in knee osteoarthritis. 
  • Daily verbal and nonverbal expression of osteoarthritis pain and spouse responses. 
  • Deep learning-based algorithm for assessment of knee osteoarthritis severity in radiographs matches performance of radiologists. 
  • Degenerative Joint Disease After Meniscectomy. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Demographic and Clinical Factors Associated With Nonsurgical Osteoarthritis Treatment Among Patients in Outpatient Clinics. 
  • Determination of Pain Phenotypes in Knee Osteoarthritis Using Latent Profile Analysis. 
  • Development of a Comprehensive, Nonsurgical Joint Health Program for People With Osteoarthritis: A Case Report. 
  • Development of a manualized protocol of massage therapy for clinical trials in osteoarthritis. 
  • Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 
  • Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice. 
  • Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. 
  • Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees. 
  • Direct in vivo evidence of activated macrophages in human osteoarthritis. 
  • Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future. 
  • Diseased Region Detection of Longitudinal Knee Magnetic Resonance Imaging Data. 
  • Diseased region detection of longitudinal knee MRI data. 
  • Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells. 
  • Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. 
  • Does functional improvement following TKA correlate to increased sports activity? 
  • Domain specific self-efficacy mediates the impact of pain catastrophizing on pain and disability in overweight and obese osteoarthritis patients. 
  • Early failure of a unicompartmental knee arthroplasty design with an all-polyethylene tibial component. 
  • Economic evaluation of access to musculoskeletal care: the case of waiting for total knee arthroplasty. 
  • Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. 
  • Effect of Comorbid Knee and Hip Osteoarthritis on Longitudinal Clinical and Health Care Use Outcomes in Older Adults With New Visits for Back Pain. 
  • Effect of High-Grade Preoperative Knee Laxity on Anterior Cruciate Ligament Reconstruction Outcomes. 
  • Effect of end-stage hip, knee, and ankle osteoarthritis on walking mechanics. 
  • Effect of motorized scooters on physical performance and mobility: a randomized clinical trial. 
  • Effectiveness of an Internet-Delivered Exercise and Pain-Coping Skills Training Intervention for Persons With Chronic Knee Pain: A Randomized Trial. 
  • Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis. 
  • Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review. 
  • Effects of Virtual Exercise Rehabilitation In-Home Therapy Compared with Traditional Care After Total Knee Arthroplasty: VERITAS, a Randomized Controlled Trial. 
  • Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study. 
  • Effects of a brief coping skills training intervention on nociceptive flexion reflex threshold in patients having osteoarthritic knee pain: a preliminary laboratory study of sex differences. 
  • Effects of external qigong therapy on osteoarthritis of the knee. A randomized controlled trial. 
  • Effects of spouse-assisted coping skills training and exercise training in patients with osteoarthritic knee pain: a randomized controlled study. 
  • Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: a randomized controlled trial. 
  • Efficacy and Safety of Massage for Osteoarthritis of the Knee: a Randomized Clinical Trial. 
  • Energy recovery in individuals with knee osteoarthritis. 
  • Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopaedic center. 
  • Establishing outcome measures in early knee osteoarthritis. 
  • Establishment of an index with increased sensitivity for assessing murine arthritis. 
  • Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project. 
  • Evaluating meniscus allograft transplant using a cost-effectiveness threshold analysis. 
  • Examining the Relationships Among Treatment, Pain, and Physical Function in Patients With Osteoarthritis: A Mediation-Modeling Approach. 
  • Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation. 
  • Extent of tibiofemoral osteoarthritis before knee arthroplasty: multicenter data from the osteoarthritis initiative. 
  • External Validation of a Prognostic Model for Predicting Nonresponse Following Knee Arthroplasty. 
  • Factors associated with rapid progression to knee arthroplasty: complete analysis of three-year data from the osteoarthritis initiative. 
  • Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice. 
  • Failure of a cemented all-polyethylene patellar component of a Press-Fit Condylar Total Knee arthroplasty. 
  • Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project. 
  • Fall Risk and Utilization of Balance Training for Adults With Symptomatic Knee Osteoarthritis: Secondary Analysis From a Randomized Clinical Trial. 
  • Fear of Movement and Associated Factors Among Adults With Symptomatic Knee Osteoarthritis. 
  • Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease. 
  • Fibromyalgia Increases the Risk of Surgical Complications Following Total Knee Arthroplasty: A Nationwide Database Study. 
  • Fixation, survival and osteolysis with a modern posterior-stabilized total knee arthroplasty. 
  • Future directions in painful knee osteoarthritis: harnessing complexity in a heterogeneous population. 
  • Gait Mechanics and T1ρ MRI of Tibiofemoral Cartilage 6 Months after ACL Reconstruction. 
  • Gender differences in pain, coping, and mood in individuals having osteoarthritic knee pain: a within-day analysis. 
  • Gender differences in patient-spouse interactions: a sequential analysis of behavioral interactions in patients having osteoarthritic knee pain. 
  • Genome-wide expression profiles of subchondral bone in osteoarthritis. 
  • Geographic region, socioeconomic position and the utilisation of primary total joint replacement for hip or knee osteoarthritis across western Victoria: a cross-sectional multilevel study of the Australian Orthopaedic Association National Joint Replacement Registry. 
  • Global Versus Momentary Osteoarthritis Pain and Emotional Distress: Emotional Intelligence as Moderator. 
  • Glucosamine may be Effective in Treating Pain due to Knee Osteoarthritis. 
  • Group Versus Individual Physical Therapy for Veterans With Knee Osteoarthritis: Randomized Clinical Trial. 
  • Group physical therapy for veterans with knee osteoarthritis: study design and methodology. 
  • Hazard of incident and progressive knee and hip radiographic osteoarthritis and chronic joint symptoms in individuals with and without limb length inequality. 
  • Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees. 
  • High body mass index is associated with increased diurnal strains in the articular cartilage of the knee. 
  • High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment. 
  • High tibial osteotomy for the treatment of unicompartmental arthritis of the knee. 
  • High tibial osteotomy: indications, techniques, and postoperative management. 
  • Hip, Knee, and Ankle Osteoarthritis Negatively Affects Mechanical Energy Exchange. 
  • Hop Testing Lacks Strong Association With Key Outcome Variables After Primary Anterior Cruciate Ligament Reconstruction: A Systematic Review. 
  • How to treat a tibial post fracture in total knee arthroplasty? A systematic review. 
  • Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression. 
  • Implementation of a group physical therapy program for Veterans with knee osteoarthritis. 
  • Increase in Free and Total Plasma TGF-β1 Following Physical Activity. 
  • Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. 
  • Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. 
  • Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise. 
  • Inflammatory biomarkers in osteoarthritis. 
  • Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments. 
  • Integrating carthage-specific T1rho MRI into knee clinic diagnostic imaging. 
  • Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease. 
  • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. 
  • Interlimb symmetry of dynamic knee joint stiffness and co-contraction is maintained in early stage knee osteoarthritis. 
  • Internet Versus DVD Decision Aids for Hip and Knee Osteoarthritis. 
  • Internet-mediated physiotherapy and pain coping skills training for people with persistent knee pain (IMPACT - knee pain): a randomised controlled trial protocol. 
  • Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee. 
  • Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels. 
  • Is synovitis detected on non-contrast-enhanced magnetic resonance imaging associated with serum biomarkers and clinical signs of effusion? Data from the Osteoarthritis Initiative. 
  • Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State. 
  • Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis. 
  • Joint space narrowing after partial medial meniscectomy in the anterior cruciate ligament-intact knee. 
  • Joint-specific hand symptoms and self-reported and performance-based functional status in African Americans and Caucasians: The Johnston County Osteoarthritis Project. 
  • KOOS pain as a marker for significant knee pain two and six years after primary ACL reconstruction: a Multicenter Orthopaedic Outcomes Network (MOON) prospective longitudinal cohort study. 
  • Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis. 
  • Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data. 
  • Knee osteoarthritis radiographic progression and associations with pain and function prior to knee arthroplasty: a multicenter comparative cohort study. 
  • Knee osteotomy and meniscal transplantation: indications, technical considerations, and results. 
  • Knee stability following anterior cruciate ligament rupture and surgery. The contribution of irreducible tibial subluxation. 
  • Letter to the Editor on Robot-Assisted Total Knee Arthroplasty Does Not Improve Long-Term Clinical and Radiologic Outcomes. 
  • Level of participation in physical therapy or an internet-based exercise training program: associations with outcomes for patients with knee osteoarthritis. 
  • Leveraging the Short-Term Benefits of Manual Therapy which Includes Exercise Over Exercise Therapy Alone Appears Justified for Knee Osteoarthritis. 
  • Limb Alignment: The Key to Success. 
  • Logistical challenges and design considerations for studies using acute anterior cruciate ligament injury as a potential model for early posttraumatic osteoarthritis. 
  • Longer term effects of total knee arthroplasty from a national longitudinal study. 
  • Longitudinal association of infrapatellar fat pad signal intensity alteration with biochemical biomarkers in knee osteoarthritis. 
  • Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium. 
  • Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers. 
  • Massage Therapy and Quality of Life in Osteoarthritis of the Knee: A Qualitative Study. 
  • Massage therapy for osteoarthritis of the knee: a randomized controlled trial. 
  • Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial. 
  • Measurement of synovial fluid volume using urea. 
  • Mechanical hyperalgesia and reduced quality of life occur in people with mild knee osteoarthritis pain. 
  • Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping. 
  • Medial Unicompartmental Arthroplasty of the Knee. 
  • Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis. 
  • Meniscus beyond mechanics: Using biology to advance our understanding of meniscus injury and treatment. 
  • Meniscus treatment and age associated with narrower radiographic joint space width 2-3 years after ACL reconstruction: data from the MOON onsite cohort. 
  • Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials. 
  • Micromechanical mapping of early osteoarthritic changes in the pericellular matrix of human articular cartilage. 
  • Model-based pain and function outcome trajectory types for patients undergoing knee arthroplasty: a secondary analysis from a randomized clinical trial. 
  • Moderators of Effects of Internet-Delivered Exercise and Pain Coping Skills Training for People With Knee Osteoarthritis: Exploratory Analysis of the IMPACT Randomized Controlled Trial. 
  • Momentary Associations of Osteoarthritis Pain and Affect: Depression as Moderator. 
  • Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. 
  • Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. 
  • Non-invasive mouse models of post-traumatic osteoarthritis. 
  • Non-verbal cues to osteoarthritic knee and/or hip pain in elders. 
  • OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA. 
  • OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. 
  • Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI. 
  • Obesity has no effect on outcomes following unicompartmental knee arthroplasty. 
  • Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation. 
  • Optimization of the fixed-flexion knee radiograph. 
  • Osteoarthritis Classification Scales: Interobserver Reliability and Arthroscopic Correlation. 
  • Osteoarthritis and the metabolic syndrome: more evidence that the etiology of OA is different in men and women. 
  • Osteoarthritis physical activity care pathway (OA-PCP): results of a feasibility trial. 
  • Osteoarthritis: Current Molecular Biomarkers and the Way Forward. 
  • Osteonecrosis of the knee: a review of three disorders. 
  • Outcomes after Total Knee Arthroplasty for post-traumatic arthritis. 
  • PIIANP and HELIXII diurnal variation. 
  • Pain Catastrophizing Predicts Opioid and Health-Care Utilization After Orthopaedic Surgery: A Secondary Analysis of Trial Participants with Spine and Lower-Extremity Disorders. 
  • Pain Coping Skills Training for Patients Who Catastrophize About Pain Prior to Knee Arthroplasty: A Multisite Randomized Clinical Trial. 
  • Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability. 
  • Pain catastrophizing in borderline morbidly obese and morbidly obese individuals with osteoarthritic knee pain. 
  • Pain communication in the context of osteoarthritis: patient and partner self-efficacy for pain communication and holding back from discussion of pain and arthritis-related concerns. 
  • Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study. 
  • Pain coping skills training for African Americans with osteoarthritis (STAART): study protocol of a randomized controlled trial. 
  • Pain coping skills training for African Americans with osteoarthritis study: baseline participant characteristics and comparison to prior studies. 
  • Pain coping skills training for African Americans with osteoarthritis: results of a randomized controlled trial. 
  • Pain coping skills training for patients with elevated pain catastrophizing who are scheduled for knee arthroplasty: a quasi-experimental study. 
  • Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA. 
  • Patellofemoral resurfacing arthroplasty: literature review and description of a novel technique. 
  • Patient Preferences for Surgical Treatment of Knee Osteoarthritis: A Discrete-Choice Experiment Evaluating Total and Unicompartmental Knee Arthroplasty. 
  • Patient and provider interventions for managing osteoarthritis in primary care: protocols for two randomized controlled trials. 
  • Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings. 
  • Patient, Provider, and Combined Interventions for Managing Osteoarthritis in Primary Care: A Cluster Randomized Trial. 
  • Patient-reported outcomes to initiate a provider-patient dialog for the management of hip and knee osteoarthritis. 
  • Peak knee biomechanics and limb symmetry following unilateral anterior cruciate ligament reconstruction: Associations of walking gait and jump-landing outcomes. 
  • Percent Body Fat Is More Predictive of Function After Total Joint Arthroplasty Than Body Mass Index. 
  • Performance Comparison of Single-Radius Versus Multiple-Curve Femoral Component in Total Knee Arthroplasty: A Prospective, Randomized Study Using the Lower Quarter Y-Balance Test. 
  • Performance of PROMIS for Healthy Patients Undergoing Meniscal Surgery. 
  • Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees. 
  • Physical Therapist-Delivered Pain Coping Skills Training and Exercise for Knee Osteoarthritis: Randomized Controlled Trial. 
  • Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee. 
  • Physical therapist-delivered cognitive-behavioral therapy: a qualitative study of physical therapists' perceptions and experiences. 
  • Physical therapy vs internet-based exercise training for patients with knee osteoarthritis: results of a randomized controlled trial. 
  • Physical therapy vs. internet-based exercise training (PATH-IN) for patients with knee osteoarthritis: study protocol of a randomized controlled trial. 
  • Pilot study of massage in veterans with knee osteoarthritis. 
  • Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis. 
  • Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate. 
  • Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial. 
  • Precocious osteoarthritis in a family with recurrent COL2A1 mutation. 
  • Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. 
  • Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium. 
  • Predictors and Outcomes of Crossover to Surgery from Physical Therapy for Meniscal Tear and Osteoarthritis: A Randomized Trial Comparing Physical Therapy and Surgery. 
  • Preoperative pain catastrophizing predicts pain outcome after knee arthroplasty. 
  • Prevalence of Total Hip and Knee Replacement in the United States. 
  • Prevalence of and characteristics associated with insomnia and obstructive sleep apnea among veterans with knee and hip osteoarthritis. 
  • Primary and Posttraumatic Knee Osteoarthritis in the Military. 
  • Primary constrained condylar knee arthroplasty for the arthritic valgus knee. 
  • Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies. 
  • Progressing toward, and recovering from, knee replacement surgery: a five-year cohort study. 
  • Prospective randomized trial of standard versus highly crosslinked tibial polyethylene in primary posterior-stabilized total knee arthroplasty: clinical and radiological follow-up at 2 to 11 years. 
  • Protein modification by deamidation indicates variations in joint extracellular matrix turnover. 
  • Psychological determinants of problematic outcomes following Total Knee Arthroplasty. 
  • Psychometric examination of the Persian version of Osteoarthritis Knee and Hip Quality of Life questionnaire. 
  • Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA). 
  • Racial Differences in Performance-Based Function and Potential Explanatory Factors Among Individuals With Knee Osteoarthritis. 
  • Racial and Ethnic Disparities in the Imaging Workup and Treatment of Knee and Hip Osteoarthritis. 
  • Racial differences in gait mechanics associated with knee osteoarthritis. 
  • Racial differences in knee osteoarthritis pain: potential contribution of occupational and household tasks. 
  • Racial differences in osteoarthritis pain and function: potential explanatory factors. 
  • Racial differences in self-reported pain and function among individuals with radiographic hip and knee osteoarthritis: the Johnston County Osteoarthritis Project. 
  • Racial/Ethnic, Socioeconomic, and Geographic Disparities in the Epidemiology of Knee and Hip Osteoarthritis. 
  • Racial/ethnic differences in sleep quality among older adults with osteoarthritis. 
  • Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. 
  • Re: Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 2008;16:137-62. 
  • Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage. 
  • Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study. 
  • Reply to Stausholm et al.'s letter to the editor regarding our published study entitled, "Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis". 
  • Results of a second-generation constrained condylar prosthesis in primary total knee arthroplasty. 
  • Results of high tibial osteotomy: review of the literature. 
  • Results of total knee replacement for isolated patellofemoral arthritis: when not to perform a patellofemoral arthroplasty. 
  • Retention of the native chondrocyte pericellular matrix results in significantly improved matrix production. 
  • Retinal arteriolar narrowing and incidence of knee replacement for osteoarthritis: a prospective cohort study. 
  • Risk of post-traumatic knee osteoarthritis after knee injury in military service members. 
  • Risk versus reward: total joint arthroplasty outcomes after various solid organ transplantations. 
  • Role of diabetes type in perioperative outcomes after hip and knee arthroplasty in the United States. 
  • STepped exercise program for patients with knee OsteoArthritis (STEP-KOA): protocol for a randomized controlled trial. 
  • Sagittal plane kinematics predict kinetics during walking gait in individuals with anterior cruciate ligament reconstruction. 
  • Same-day Bilateral Total Knee Arthroplasty Did Not Increase 90-day Hospital Returns. 
  • Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change. 
  • Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium. 
  • Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. 
  • Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis. 
  • Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis. 
  • Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. 
  • Sex differences in biomechanics associated with knee osteoarthritis. 
  • Should intra-articular hyaluronic acid be used routinely for knee osteoarthritis pain? 
  • Simultaneous vs staged bilateral total knee arthroplasty among Medicare beneficiaries, 2000-2009. 
  • Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing. 
  • Sociodemographic and Clinical Correlates of Physical Therapy Utilization in Adults With Symptomatic Knee Osteoarthritis. 
  • Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis. 
  • Some disease-modifying osteoarthritis drugs make small improvements in knee and hip osteoarthritis. 
  • Sports after knee arthroplasty: partial versus total knee arthroplasty. 
  • Spouse confidence in self-efficacy for arthritis management predicts improved patient health. 
  • Spouse-assisted coping skills training in the management of knee pain in osteoarthritis: long-term followup results. 
  • Stepped Exercise Program for Patients With Knee Osteoarthritis : A Randomized Controlled Trial. 
  • Stochastic resonance electrical stimulation to improve proprioception in knee osteoarthritis. 
  • Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression. 
  • Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis. 
  • Summary for Patients: A Stepped Exercise Program for Patients With Knee Osteoarthritis. 
  • Surgery versus physical therapy for a meniscal tear and osteoarthritis. 
  • Surgical Management and Treatment of the Anterior Cruciate Ligament-Deficient Knee with Malalignment. 
  • Surgical Predictors of Clinical Outcomes After Revision Anterior Cruciate Ligament Reconstruction. 
  • Surgical treatment of the middle-aged patient with arthritic knees. 
  • Symptomatic hyponatremia in patients undergoing total hip and knee arthroplasty. A report of three cases. 
  • Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression. 
  • Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA). 
  • Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation. 
  • Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. 
  • Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain. 
  • TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression. 
  • TSG-6 - a double-edged sword for osteoarthritis (OA). 
  • TSG-6 activity as a novel biomarker of progression in knee osteoarthritis. 
  • Telephone-based self-management of osteoarthritis: A randomized trial. 
  • Ten-Year Outcomes and Risk Factors After Anterior Cruciate Ligament Reconstruction: A MOON Longitudinal Prospective Cohort Study. 
  • The Association of Recreational and Competitive Running With Hip and Knee Osteoarthritis: A Systematic Review and Meta-analysis. 
  • The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function. 
  • The Clinical Radiographic Incidence of Posttraumatic Osteoarthritis 10 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON Nested Cohort. 
  • The Influence of Exercise Dosing on Outcomes in Patients With Knee Disorders: A Systematic Review. 
  • The assessment of postural control with stochastic resonance electrical stimulation and a neoprene knee sleeve in the osteoarthritic knee. 
  • The association of comorbid conditions with patient-reported outcomes in Veterans with hip and knee osteoarthritis. 
  • The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis. 
  • The effect of dynamic mechanical compression on nitric oxide production in the meniscus. 
  • The effects of total knee arthroplasty on physical functioning and health among the under age 65 population. 
  • The effects of total knee arthroplasty on physical functioning in the older population. 
  • The impact of daily arthritis pain on spouse sleep. 
  • The impact of stochastic resonance electrical stimulation and knee sleeve on impulsive loading and muscle co-contraction during gait in knee osteoarthritis. 
  • The incidence of enlarged chondrons in normal and osteoarthritic human cartilage and their relative matrix density. 
  • The incidence of heterotopic ossification after total knee arthroplasty. 
  • The long-term outcome of total knee patients with moderate loss of motion. 
  • The rates of osteolysis and loosening associated with a modular posterior stabilized knee replacement. Results at five to fourteen years. 
  • The relationship between retinal vessel calibre and knee cartilage and BMLs. 
  • The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: the role of catastrophizing. 
  • The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritis. 
  • Total knee arthroplasty using cementless keels and cemented tibial trays: 10-year results. 
  • Toward classification criteria for early osteoarthritis of the knee. 
  • Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. 
  • Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression. 
  • Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. 
  • Treatment effectiveness and fidelity of manual therapy to the knee: A systematic review and meta-analysis. 
  • Trends in Opioid Utilization Before and After Total Knee Arthroplasty. 
  • Two-year incidence and predictors of future knee arthroplasty in persons with symptomatic knee osteoarthritis: preliminary analysis of longitudinal data from the osteoarthritis initiative. 
  • Unicompartmental Knee Arthroplasty: More Conversions, Fewer Complications Than Proximal Tibial Osteotomy in a Young Population. 
  • Unicompartmental knee arthroplasty: factors influencing the outcome. 
  • Unicompartmental osteoarthritis in the active patient: the role of high tibial osteotomy. 
  • Upper partial fibulectomy improves knee biomechanics and function and decreases knee pain of osteoarthritis: A pilot and biomechanical study. 
  • Using surgical appropriateness criteria to examine outcomes of total knee arthroplasty in a United States sample. 
  • Validity and reliability of radiographic knee osteoarthritis measures by arthroplasty surgeons. 
  • Variation of serum hyaluronan with activity in individuals with knee osteoarthritis. 
  • Viscosupplementation for knee osteoarthritis. 
  • What General and Pain-associated Psychological Distress Phenotypes Exist Among Patients with Hip and Knee Osteoarthritis? 
  • Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation. 
  • Xanthine oxidase injurious response in acute joint injury. 
• 

  Keywords of People

  • Anwar, Muhammad Farooq, Assistant Professor of Anesthesiology, Anesthesiology, Pain Management
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Hsueh, Ming-Feng, Assistant Professor in Orthopaedic Surgery, Duke Molecular Physiology Institute
  • Ramirez, Michelle, Student, Population Health Sciences
  • Ryan, Sean, Assistant Professor of Orthopaedic Surgery, Orthopaedic Surgery
  • Shih, Yu Ru, Assistant Professor of Orthopaedic Surgery, Orthopaedic Surgery
  • Yancy Jr., William Samuel, Professor of Medicine, Medicine, General Internal Medicine