Interleukin-17

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  Subject Areas on Research

  • A Novel Mechanism for Th17 Inflammation in Human Type 2 Diabetes Mellitus. 
  • A Prognostic Model of Persistent Bacteremia and Mortality in Complicated Staphylococcus aureus Bloodstream Infection. 
  • A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. 
  • Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. 
  • Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. 
  • Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population. 
  • Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide. 
  • Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. 
  • B cell depletion reduces the development of atherosclerosis in mice. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Circulating Mucosal-Associated Invariant T Cells in a Large Cohort of Healthy Chinese Individuals From Newborn to Elderly. 
  • Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. 
  • Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. 
  • Dendritic epidermal T cells regulate skin antimicrobial barrier function. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. 
  • Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome. 
  • Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma. 
  • ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. 
  • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • IFN-beta inhibits human Th17 cell differentiation. 
  • IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation. 
  • IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection. 
  • IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. 
  • IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. 
  • IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection. 
  • IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease. 
  • IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription. 
  • IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity. 
  • Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. 
  • Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis. 
  • Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: an open-label two-arm trial. 
  • In pursuit of new experimental models of obliterative bronchiolitis. 
  • Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response. 
  • Inflammation Gets on the Lung's Nerves: IL-17 and Neuroendocrine Cells Mediate Ozone Responses in Obesity. 
  • Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88. 
  • Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis. 
  • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. 
  • Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci. 
  • Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells. 
  • JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation. 
  • Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. 
  • Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner. 
  • Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. 
  • Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells. 
  • Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. 
  • PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. 
  • Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles. 
  • Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. 
  • Proinflammatory cytokine expression profile in degenerated and herniated human intervertebral disc tissues. 
  • Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory. 
  • Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression. 
  • Regulation of T-helper-cell lineage development by osteopontin: the inside story. 
  • Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. 
  • Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. 
  • Role of complement activation in obliterative bronchiolitis post-lung transplantation. 
  • Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis. 
  • Secukinumab (AIN-457) for the treatment of Psoriasis. 
  • Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. 
  • Synthesis and Biological Evaluation of Subglutinol Analogs for Immunomodulatory Agents. 
  • T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis. 
  • T helper subsets in allergic eye disease. 
  • T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair. 
  • TNF-α in T lymphocytes attenuates renal injury and fibrosis during nephrotoxic nephritis. 
  • The Inhibitory Effect of Rapamycin on Toll Like Receptor 4 and Interleukin 17 in the Early Stage of Rat Diabetic Nephropathy. 
  • The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients. 
  • The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells. 
  • Tγδ17 cells build up the nerve. 
  • Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis. 
  • iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. 
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  Keywords of People

  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology