Interleukin-18

• 

  Subject Areas on Research

  • A Functional Interleukin-18 Haplotype Predicts Depression and Anxiety through Increased Threat-Related Amygdala Reactivity in Women but Not Men. 
  • A noncanonical function of cGAMP in inflammasome priming and activation. 
  • Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth. 
  • Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. 
  • Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis. 
  • Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. 
  • Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesis. 
  • Biomarkers predict progression of acute kidney injury after cardiac surgery. 
  • Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery. 
  • Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. 
  • Caspase-1-induced pyroptotic cell death. 
  • Cytokine profiles of preterm neonates with fungal and bacterial sepsis. 
  • Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. 
  • Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury. 
  • Emerging concepts in acute kidney injury following cardiac surgery. 
  • First Post-Operative Urinary Kidney Injury Biomarkers and Association with the Duration of AKI in the TRIBE-AKI Cohort. 
  • Generation of a Listeria vaccine strain by enhanced caspase-1 activation. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • IL-1β, IL-18, and eicosanoids promote neutrophil recruitment to pore-induced intracellular traps following pyroptosis. 
  • Immunotherapy using allogeneic squamous cell tumor-dendritic cell fusion hybrids. 
  • Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. 
  • Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). 
  • Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection. 
  • Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. 
  • Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes. 
  • Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation. 
  • Mesenchymal stem cells stimulate protective genetic reprogramming of injured cardiac ventricular myocytes. 
  • Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. 
  • Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. 
  • Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. 
  • Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. 
  • Pyroptotic cell death defends against intracellular pathogens. 
  • Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. 
  • Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. 
  • The Clinical Utility and Assessment of Renal Biomarkers in Acute Kidney Injury After Abdominal Endovascular Aneurysm Repair. A Systematic Review. 
  • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. 
  • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. 
  • The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury. 
  • Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Clyde, Merlise, Professor of Statistical Science, Statistical Science
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Patel, Uptal Dinesh, Adjunct Professor in the Department of Medicine, Medicine, Nephrology