Receptors, Interleukin-7
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Subject Areas on Research
- Alternative splicing in multiple sclerosis and other autoimmune diseases.
- B-cell reconstitution for SCID: should a conditioning regimen be used in SCID treatment?
- Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.
- Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.
- E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.
- Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor.
- IL-7 enhances the survival and maintains the size of naive T cells.
- IL-7 is essential for homeostatic control of T cell metabolism in vivo.
- Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.
- Interleukin 7 receptor alpha-chain-mutation severe combined immunodeficiency without lymphopenia: correction with haploidentical T-cell-depleted bone marrow transplantation.
- Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.
- Jak3 and the pathogenesis of severe combined immunodeficiency.
- The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
- The common gamma-chain of cytokine receptors regulates intrathymic T cell development at multiple stages.
- Type 17 CD8+ T cells display enhanced antitumor immunity.
- Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
- Unusual clinical and immunologic manifestations of transplacentally acquired maternal T cells in severe combined immunodeficiency.
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Keywords of People
- Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology