Molecular Motor Proteins

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  Subject Areas on Research

  • A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes. 
  • A mutant of the motor protein kinesin that moves in both directions on microtubules. 
  • A new kinesin tree. 
  • A new structural state of myosin. 
  • A structural pathway for activation of the kinesin motor ATPase. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • A unidirectional DNA walker that moves autonomously along a track. 
  • APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. 
  • Active cellular materials. 
  • An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character. 
  • Angiotensin-II mediates nonmuscle myosin II activation and expression and contributes to human keloid disease progression. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Assembly pathway of the anastral Drosophila oocyte meiosis I spindle. 
  • Asymmetric division: AGS proteins position the spindle. 
  • B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Biochemistry. Friction in motor proteins. 
  • Control of a biomolecular motor-powered nanodevice with an engineered chemical switch. 
  • Cooperative behavior of molecular motors. 
  • Decoupling of nucleotide- and microtubule-binding sites in a kinesin mutant. 
  • Determinants of molecular motor directionality. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Directionality and processivity of molecular motors. 
  • Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor. 
  • Force generation by kinesin and myosin cytoskeletal motor proteins. 
  • Genomic sequencing-based mutational enrichment analysis identifies motility genes in a genetically intractable gut microbe. 
  • Genotype-phenotype correlation in MYH9-related thrombocytopenia. 
  • Green fluorescent protein as a tag for molecular motor proteins. 
  • High-resolution mapping of intracellular fluctuations using carbon nanotubes. 
  • Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. 
  • In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. 
  • Kinesin motors as molecular machines. 
  • Kinesin: switch I & II and the motor mechanism. 
  • Kinesins at a glance. 
  • Light-driven translocation of signaling proteins in vertebrate photoreceptors. 
  • MYH9 and APOL1 are both associated with sickle cell disease nephropathy. 
  • Molecular motors--a paradigm for mutant analysis. 
  • Moving into the cell: single-molecule studies of molecular motors in complex environments. 
  • Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. 
  • Myosin I contributes to the generation of resting cortical tension. 
  • Myosin head configuration in relaxed insect flight muscle: x-ray modeled resting cross-bridges in a pre-powerstroke state are poised for actin binding. 
  • Nonequilibrium mechanics of active cytoskeletal networks. 
  • On the Functional Role of Valve Interstitial Cell Stress Fibers: A Continuum Modeling Approach. 
  • Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. 
  • Processive and nonprocessive models of kinesin movement. 
  • Rapid double 8-nm steps by a kinesin mutant. 
  • Report of a young girl with MYH9 mutation and review of the literature. 
  • Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles. 
  • Structural biology of plasmid partition: uncovering the molecular mechanisms of DNA segregation. 
  • The Drosophila centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo. 
  • The ciliopathies: an emerging class of human genetic disorders. 
  • The minus end-directed motor Kar3 is required for coupling dynamic microtubule plus ends to the cortical shmoo tip in budding yeast. 
  • Working strokes by single molecules of the kinesin-related microtubule motor ncd.