Multifactorial Inheritance

• 

  Subject Areas on Research

  • A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains. 
  • A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence. 
  • A genome-wide association study for extremely high intelligence. 
  • A genomic screen of autism: evidence for a multilocus etiology. 
  • A polygenic p factor for major psychiatric disorders. 
  • Adjusting for covariates on a slippery slope: linkage analysis of change over time. 
  • Age at onset in two common neurodegenerative diseases is genetically controlled. 
  • An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility. 
  • Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers. 
  • Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. 
  • Complex trait genetics of refractive error. 
  • Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis. 
  • Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians. 
  • Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. 
  • ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. 
  • Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults. 
  • Epistasis and balanced polymorphism influencing complex trait variation. 
  • Evaluation of the Genetic Variance of Alzheimer's Disease Explained by the Disease-Associated Chromosomal Regions. 
  • Extension of multifactor dimensionality reduction for identifying multilocus effects in the GAW14 simulated data. 
  • Fine mapping genetic associations between the HLA region and extremely high intelligence. 
  • GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. 
  • Genetic Analysis of Complex Traits in Saccharomyces cerevisiae . 
  • Genetic architecture of gene expression traits across diverse populations. 
  • Genetic determinants of childhood and adult height associated with osteosarcoma risk. 
  • Genetic trade-offs and conditional neutrality contribute to local adaptation. 
  • Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior. 
  • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. 
  • Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. 
  • Genomics of Cardiovascular Measures of Autonomic Tone. 
  • Genomics: Lessons in complexity from yeast. 
  • Heritability of cardiovascular and personality traits in 6,148 Sardinians. 
  • Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations. 
  • Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. 
  • Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. 
  • Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. 
  • Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. 
  • Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits. 
  • Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. 
  • Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. 
  • Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. 
  • Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective. 
  • Multiethnic polygenic risk scores improve risk prediction in diverse populations. 
  • Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. 
  • Physiological Genomics: Who we are and where we're going. 
  • Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure. 
  • Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). 
  • Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study. 
  • Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls. 
  • Polygenic risk score for disability and insights into disability-related molecular mechanisms. 
  • Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. 
  • Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. 
  • Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children. 
  • Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. 
  • Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene. 
  • Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Rare-variant collapsing analyses for complex traits: guidelines and applications. 
  • Schizophrenia polygenic risk score predicts mnemonic hippocampal activity. 
  • Selective trade-offs maintain alleles underpinning complex trait variation in plants. 
  • Sex Differences in Genetic Associations With Longevity. 
  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 
  • Studying genetic resilience to improve human health. 
  • Summarizing polygenic risks for complex diseases in a clinical whole-genome report. 
  • The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. 
  • The Polygenic and Monogenic Basis of Blood Traits and Diseases. 
  • The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees. 
  • Transancestral mapping and genetic load in systemic lupus erythematosus. 
  • Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. 
  • Update on psychiatric genetics. 
  • Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome. 
• 

  Keywords of People

  • Bowes Rickman, Catherine, Professor of Ophthalmology, Cell Biology
  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology
  • Routh, Jonathan Charles, Paul H. Sherman, M.D. Distinguished Associate Professor of Surgery, Pediatrics