Multifactorial Inheritance
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Subject Areas on Research
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A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains.
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A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence
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A genome-wide association study for extremely high intelligence.
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A genomic screen of autism: evidence for a multilocus etiology.
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A polygenic p factor for major psychiatric disorders.
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A polygenic score for age-at-first-birth predicts disinhibition.
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A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation.
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Addressing the challenges of polygenic scores in human genetic research.
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Adjusting for covariates on a slippery slope: linkage analysis of change over time.
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Age at onset in two common neurodegenerative diseases is genetically controlled.
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An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility.
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Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data.
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Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
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Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.
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Complex trait genetics of refractive error.
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Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.
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Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis.
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Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians.
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Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium.
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ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration.
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Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults.
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Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.
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Epistasis and balanced polymorphism influencing complex trait variation.
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Evaluation of the Genetic Variance of Alzheimer's Disease Explained by the Disease-Associated Chromosomal Regions.
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Extension of multifactor dimensionality reduction for identifying multilocus effects in the GAW14 simulated data.
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Fine mapping genetic associations between the HLA region and extremely high intelligence.
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
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Gene expression elucidates functional impact of polygenic risk for schizophrenia.
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Genetic Analysis of Complex Traits in Saccharomyces cerevisiae
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Genetic architecture of gene expression traits across diverse populations.
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Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.
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Genetic determinants of childhood and adult height associated with osteosarcoma risk.
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Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.
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Genetic trade-offs and conditional neutrality contribute to local adaptation.
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Genetic variants associated with sepsis.
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Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior.
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Genome-wide analysis of genetic predisposition to common polygenic cancers.
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
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Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder.
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Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.
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Genomics of Cardiovascular Measures of Autonomic Tone.
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Genomics: Lessons in complexity from yeast.
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Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.
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Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.
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Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review.
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Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals.
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Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.
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Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.
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Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
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Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD.
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Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
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Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits.
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Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.
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Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
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Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective.
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Multiethnic polygenic risk scores improve risk prediction in diverse populations.
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Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.
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Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms.
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Physiological Genomics: Who we are and where we're going.
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Polygenic Risk and the Course of Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood: Findings From a Nationally Representative Cohort.
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Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure.
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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
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Polygenic loading for major depression is associated with specific medical comorbidity.
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Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.
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Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study
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Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls.
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Polygenic risk score for disability and insights into disability-related molecular mechanisms.
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Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.
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Polygenic risk scores for CARDINAL study.
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Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study.
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Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children.
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Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
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Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.
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Rare and low-frequency coding variants alter human adult height.
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Rare-variant collapsing analyses for complex traits: guidelines and applications.
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Resource profile and user guide of the Polygenic Index Repository.
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Schizophrenia polygenic risk score predicts mnemonic hippocampal activity.
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Selective trade-offs maintain alleles underpinning complex trait variation in plants.
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Sex Differences in Genetic Associations With Longevity.
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Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis.
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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
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Studying genetic resilience to improve human health.
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Summarizing polygenic risks for complex diseases in a clinical whole-genome report.
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The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development.
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The Polygenic and Monogenic Basis of Blood Traits and Diseases.
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The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies.
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The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees.
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The shared genetic architecture between epidemiological and behavioral traits with lung cancer.
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Transancestral mapping and genetic load in systemic lupus erythematosus.
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Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.
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Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.
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Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder.
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Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis.
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Update on psychiatric genetics.
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Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome.
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Keywords of People
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Bowes Rickman, Catherine,
George and Geneva Boguslavsky Distinguished Professor of Eye Research,
Cell Biology
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Mitchell-Olds, Thomas,
Newman Ivey White Distinguished Professor of Biology,
Biology
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Routh, Jonathan Charles,
Paul H. Sherman, M.D. Distinguished Associate Professor of Surgery,
Pediatrics