Multifactorial Inheritance
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Subject Areas on Research
- A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence.
- A genome-wide association study for extremely high intelligence.
- A polygenic p factor for major psychiatric disorders.
- Adjusting for covariates on a slippery slope: linkage analysis of change over time.
- Age at onset in two common neurodegenerative diseases is genetically controlled.
- Beyond Mendel: an evolving view of human genetic disease transmission.
- Complex trait genetics of refractive error.
- Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis.
- Dissection of epistasis in oligogenic Bardet-Biedl syndrome.
- ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration.
- Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults.
- Epistasis and balanced polymorphism influencing complex trait variation.
- Extension of multifactor dimensionality reduction for identifying multilocus effects in the GAW14 simulated data.
- Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States.
- Fine mapping genetic associations between the HLA region and extremely high intelligence.
- GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.
- Gene expression elucidates functional impact of polygenic risk for schizophrenia.
- Genetic Analysis of Complex Traits in Saccharomyces cerevisiae.
- Genetic modifiers and oligogenic inheritance.
- Genetic trade-offs and conditional neutrality contribute to local adaptation.
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
- Genomics of Cardiovascular Measures of Autonomic Tone.
- Genomics: Lessons in complexity from yeast.
- Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.
- Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder.
- Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
- Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits.
- Loss of δ-catenin function in severe autism.
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.
- Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
- Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.
- Physiological Genomics: Who we are and where we're going.
- Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
- Polygenic loading for major depression is associated with specific medical comorbidity.
- Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.
- Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls.
- Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study.
- Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders.
- Population genetic structure of variable drug response.
- Rare and low-frequency coding variants alter human adult height.
- Selective trade-offs maintain alleles underpinning complex trait variation in plants.
- Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
- Studying genetic resilience to improve human health.
- Summarizing polygenic risks for complex diseases in a clinical whole-genome report.
- The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development.
- The oligogenic properties of Bardet-Biedl syndrome.
- Transancestral mapping and genetic load in systemic lupus erythematosus.
- Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.
- Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder.
- Triallelic inheritance: a bridge between Mendelian and multifactorial traits.
- Update on psychiatric genetics.
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Keywords of People
- Bowes Rickman, Catherine, Professor of Ophthalmology, Cell Biology
- Mitchell-Olds, Thomas, Newman Ivey White Professor of Biology in Trinity College of Arts and Sciences, Biology
- Routh, Jonathan Charles, Paul H. Sherman, M.D. Associate Professor of Surgery, Pediatrics