Multifactorial Inheritance

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  Subject Areas on Research

  • A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence. 
  • A genome-wide association study for extremely high intelligence. 
  • A polygenic p factor for major psychiatric disorders. 
  • Adjusting for covariates on a slippery slope: linkage analysis of change over time. 
  • Age at onset in two common neurodegenerative diseases is genetically controlled. 
  • Beyond Mendel: an evolving view of human genetic disease transmission. 
  • Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. 
  • Complex trait genetics of refractive error. 
  • Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis. 
  • Dissection of epistasis in oligogenic Bardet-Biedl syndrome. 
  • Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. 
  • ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. 
  • Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults. 
  • Epistasis and balanced polymorphism influencing complex trait variation. 
  • Extension of multifactor dimensionality reduction for identifying multilocus effects in the GAW14 simulated data. 
  • Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States. 
  • Fine mapping genetic associations between the HLA region and extremely high intelligence. 
  • GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. 
  • Gene expression elucidates functional impact of polygenic risk for schizophrenia. 
  • Genetic Analysis of Complex Traits in Saccharomyces cerevisiae. 
  • Genetic architecture of gene expression traits across diverse populations. 
  • Genetic determinants of childhood and adult height associated with osteosarcoma risk. 
  • Genetic modifiers and oligogenic inheritance. 
  • Genetic trade-offs and conditional neutrality contribute to local adaptation. 
  • Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior. 
  • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. 
  • Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. 
  • Genomics of Cardiovascular Measures of Autonomic Tone. 
  • Genomics: Lessons in complexity from yeast. 
  • Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. 
  • Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. 
  • Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. 
  • Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits. 
  • Loss of δ-catenin function in severe autism. 
  • Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. 
  • Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. 
  • Multiethnic polygenic risk scores improve risk prediction in diverse populations. 
  • Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. 
  • Physiological Genomics: Who we are and where we're going. 
  • Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). 
  • Polygenic loading for major depression is associated with specific medical comorbidity. 
  • Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study. 
  • Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls. 
  • Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. 
  • Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. 
  • Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children. 
  • Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. 
  • Population genetic structure of variable drug response. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Schizophrenia polygenic risk score predicts mnemonic hippocampal activity. 
  • Selective trade-offs maintain alleles underpinning complex trait variation in plants. 
  • Sex Differences in Genetic Associations With Longevity. 
  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 
  • Studying genetic resilience to improve human health. 
  • Summarizing polygenic risks for complex diseases in a clinical whole-genome report. 
  • The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. 
  • The oligogenic properties of Bardet-Biedl syndrome. 
  • The prediction of disease risk in genomic medicine. 
  • Transancestral mapping and genetic load in systemic lupus erythematosus. 
  • Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. 
  • Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder. 
  • Triallelic inheritance: a bridge between Mendelian and multifactorial traits. 
  • Update on psychiatric genetics. 
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  Keywords of People

  • Bowes Rickman, Catherine, Professor of Ophthalmology, Cell Biology
  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology
  • Routh, Jonathan Charles, Paul H. Sherman, M.D. Distinguished Associate Professor of Surgery, Pediatrics