Multifactorial Inheritance

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  Subject Areas on Research

  • A Polygenic Score for Higher Educational Attainment is Associated with Larger Brains. 
  • A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence 
  • A genome-wide association study for extremely high intelligence. 
  • A genomic screen of autism: evidence for a multilocus etiology. 
  • A polygenic p factor for major psychiatric disorders. 
  • A polygenic score for age-at-first-birth predicts disinhibition. 
  • A polygenic score for body mass index is associated with depressive symptoms via early life stress: Evidence for gene-environment correlation. 
  • Addressing the challenges of polygenic scores in human genetic research. 
  • Adjusting for covariates on a slippery slope: linkage analysis of change over time. 
  • Age at onset in two common neurodegenerative diseases is genetically controlled. 
  • An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility. 
  • Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. 
  • Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers. 
  • Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. 
  • Complex trait genetics of refractive error. 
  • Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course. 
  • Costs and consequences of universal sibling screening for vesicoureteral reflux: decision analysis. 
  • Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians. 
  • Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. 
  • ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. 
  • Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance During Working Memory Subprocesses in Healthy Young Adults. 
  • Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor. 
  • Epistasis and balanced polymorphism influencing complex trait variation. 
  • Evaluation of the Genetic Variance of Alzheimer's Disease Explained by the Disease-Associated Chromosomal Regions. 
  • Extension of multifactor dimensionality reduction for identifying multilocus effects in the GAW14 simulated data. 
  • Fine mapping genetic associations between the HLA region and extremely high intelligence. 
  • GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. 
  • Gene expression elucidates functional impact of polygenic risk for schizophrenia. 
  • Genetic Analysis of Complex Traits in Saccharomyces cerevisiae . 
  • Genetic architecture of gene expression traits across diverse populations. 
  • Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. 
  • Genetic determinants of childhood and adult height associated with osteosarcoma risk. 
  • Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits. 
  • Genetic trade-offs and conditional neutrality contribute to local adaptation. 
  • Genetic variants associated with sepsis. 
  • Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior. 
  • Genome-wide analysis of genetic predisposition to common polygenic cancers. 
  • Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. 
  • Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. 
  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. 
  • Genomics of Cardiovascular Measures of Autonomic Tone. 
  • Genomics: Lessons in complexity from yeast. 
  • Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations. 
  • Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. 
  • Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review. 
  • Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals. 
  • Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data. 
  • Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction. 
  • Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. 
  • Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD. 
  • Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. 
  • Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits. 
  • Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. 
  • Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. 
  • Morphomechanic phenotypic variability of sarcomeric cardiomyopathies: A multifactorial polygenic perspective. 
  • Multiethnic polygenic risk scores improve risk prediction in diverse populations. 
  • Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. 
  • Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms. 
  • Physiological Genomics: Who we are and where we're going. 
  • Polygenic Risk and the Course of Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood: Findings From a Nationally Representative Cohort. 
  • Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure. 
  • Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). 
  • Polygenic loading for major depression is associated with specific medical comorbidity. 
  • Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. 
  • Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study 
  • Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls. 
  • Polygenic risk score for disability and insights into disability-related molecular mechanisms. 
  • Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia. 
  • Polygenic risk scores for CARDINAL study. 
  • Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study. 
  • Polygenic scores associated with educational attainment in adults predict educational achievement and ADHD symptoms in children. 
  • Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. 
  • Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Rare-variant collapsing analyses for complex traits: guidelines and applications. 
  • Resource profile and user guide of the Polygenic Index Repository. 
  • Schizophrenia polygenic risk score predicts mnemonic hippocampal activity. 
  • Selective trade-offs maintain alleles underpinning complex trait variation in plants. 
  • Sex Differences in Genetic Associations With Longevity. 
  • Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis. 
  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 
  • Studying genetic resilience to improve human health. 
  • Summarizing polygenic risks for complex diseases in a clinical whole-genome report. 
  • The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. 
  • The Polygenic and Monogenic Basis of Blood Traits and Diseases. 
  • The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies. 
  • The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees. 
  • The shared genetic architecture between epidemiological and behavioral traits with lung cancer. 
  • Transancestral mapping and genetic load in systemic lupus erythematosus. 
  • Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. 
  • Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. 
  • Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder. 
  • Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. 
  • Update on psychiatric genetics. 
  • Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 deletion syndrome. 
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  Keywords of People

  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology
  • Routh, Jonathan Charles, Paul H. Sherman, M.D. Distinguished Associate Professor of Surgery, Pediatrics