Photoreceptor Cells, Vertebrate

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  Subject Areas on Research

  • A novel method for comparative analysis of retinal specialization traits from topographic maps. 
  • Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. 
  • Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. 
  • Afferent control of horizontal cell morphology revealed by genetic respecification of rods and cones. 
  • Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7. 
  • Association of whirlin with Cav1.3 (alpha1D) channels in photoreceptors, defining a novel member of the usher protein network. 
  • Beyond counting photons: trials and trends in vertebrate visual transduction. 
  • Biology and functions of the RGS9 isoforms. 
  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. 
  • Cell death in age-related macular degeneration. 
  • Clinicopathologic studies of eyes that were obtained postmortem from four patients who were enrolled in the submacular surgery trials: SST Report No. 16. 
  • Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. 
  • Defining the human macula transcriptome and candidate retinal disease genes using EyeSAGE. 
  • Disease expression of RP1 mutations causing autosomal dominant retinitis pigmentosa. 
  • Diurnal changes in exocytosis and the number of synaptic ribbons at active zones of an ON-type bipolar cell terminal. 
  • Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration. 
  • Downregulation of a unique photoreceptor protein correlates with improper outer segment assembly. 
  • Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. 
  • Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. 
  • Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus. 
  • Extraocular, Non-Visual, and Simple Photoreceptors: An Introduction to the Symposium. 
  • Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. 
  • Functional comparison of RGS9 splice isoforms in a living cell. 
  • Fundus albipunctatus in a 6-year old girl due to compound heterozygous mutations in the RDH5 gene. 
  • Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. 
  • Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons. 
  • Identification of nonvisual photomotor response cells in the vertebrate hindbrain. 
  • Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors. 
  • Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. 
  • Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. 
  • Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs. 
  • Light-dependent magnetoreception: quantum catches and opponency mechanisms of possible photosensitive molecules. 
  • Light-driven translocation of signaling proteins in vertebrate photoreceptors. 
  • MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. 
  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. 
  • Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology. 
  • Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors. 
  • Modelling colour constancy in fish: implications for vision and signalling in water. 
  • Multifocal electroretinogram in rhodopsin P347L transgenic pigs. 
  • Optical coherence tomography of choroidal osteoma in 22 cases: evidence for photoreceptor atrophy over the decalcified portion of the tumor. 
  • Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss. 
  • Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration. 
  • Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse. 
  • Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in vivo with spectral-domain optical coherence tomography. 
  • Photoreceptor light adaptation. Untangling desensitization and sensitization. 
  • Photoreceptor loss overlying congenital hypertrophy of the retinal pigment epithelium by optical coherence tomography. 
  • Photoreceptor signaling: supporting vision across a wide range of light intensities. 
  • Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. 
  • Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis. 
  • Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability. 
  • Protein sorting, targeting and trafficking in photoreceptor cells. 
  • Protein translocation in photoreceptor light adaptation: a common theme in vertebrate and invertebrate vision. 
  • Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells. 
  • RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. 
  • Regulated heat shock protein 27 expression in human retinal pigment epithelium. 
  • Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. 
  • Role of the Fas-signaling pathway in photoreceptor neuroprotection. 
  • SAFETY PROFILE OF OCRIPLASMIN FOR SYMPTOMATIC VITREOMACULAR ADHESION: A Comprehensive Analysis of Premarketing and Postmarketing Experiences. 
  • Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species. 
  • Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity. 
  • Spectral domain optical coherence tomography imaging of geographic atrophy margins. 
  • Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina. 
  • Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. 
  • Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors. 
  • The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein. 
  • The relationship between slow photoresponse recovery rate and temporal resolution of vision. 
  • Timing is everything: GTPase regulation in phototransduction. 
  • Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). 
  • Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration? 
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  Keywords of People

  • Farsiu, Sina, Paul Ruffin Scarborough Associate Professor of Engineering, Electrical and Computer Engineering
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery