Gene Duplication

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  Subject Areas on Research

  • A New Resource for Characterizing X-linked Genes in Drosophila melanogaster: Systematic Coverage and Subdivision of the X Chromosome with Nested, Y-linked Duplications. 
  • A duplication in chromosome 4q35 is associated with hereditary benign intraepithelial dyskeratosis. 
  • A gene duplication of a septin reveals a developmentally regulated filament length control mechanism. 
  • A patient with duplication (7)(p22.1pter) characterized by array-CGH. 
  • A physical map of the human genome. 
  • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. 
  • Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. 
  • Adaptive evolution drives the diversification of zinc-finger binding domains. 
  • Analyses of transcriptome sequences reveal multiple ancient large-scale duplication events in the ancestor of Sphagnopsida (Bryophyta). 
  • Ancient Gene Duplications, Rather Than Polyploidization, Facilitate Diversification of Petal Pigmentation Patterns in Clarkia gracilis (Onagraceae). 
  • Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma. 
  • Chromosomal translocation and segmental duplication in Cryptococcus neoformans. 
  • Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. 
  • Comparative evolutionary analysis of chalcone synthase and alcohol dehydrogenase loci in Arabidopsis, Arabis, and related genera (Brassicaceae). 
  • Comparative genomics in the Brassicaceae: a family-wide perspective. 
  • Complete vertebrate mitogenomes reveal widespread repeats and gene duplications. 
  • Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. 
  • Context-dependent effects of whole-genome duplication during mammary tumor recurrence. 
  • De novo partial duplication of chromosome 7p in a male with autistic disorder. 
  • Defining the polyposis/colorectal cancer phenotype associated with the Ashkenazi GREM1 duplication: counselling and management recommendations. 
  • Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade. 
  • Escape from adaptive conflict after duplication in an anthocyanin pathway gene. 
  • Evidence for involvement of GNB1L in autism. 
  • Evolution of multiple paralogous adenosine kinase genes in the moss genus Hygroamblystegium: phylogenetic implications. 
  • Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates. 
  • Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication. 
  • FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. 
  • Fern genomes elucidate land plant evolution and cyanobacterial symbioses 
  • Fine mapping of the Pc locus of Sorghum bicolor, a gene controlling the reaction to a fungal pathogen and its host-selective toxin. 
  • Finishing the euchromatic sequence of the human genome. 
  • Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae. 
  • Gene copy-number variation in haploid and diploid strains of the yeast Saccharomyces cerevisiae. 
  • Gene duplication in Mimulus underlies parallel floral evolution via independent trans-regulatory changes. 
  • Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Genetic heterogeneity of gingival fibromatosis on chromosome 2p. 
  • Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Hybrid male sterility in Mimulus (Phrymaceae) is associated with a geographically restricted mitochondrial rearrangement. 
  • Hypotrichosis-lymphedema-telangiectasia syndrome: Report of ileal atresia associated with a SOX18 de novo pathogenic variant and review of the phenotypic spectrum. 
  • Initial sequencing and analysis of the human genome. 
  • Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). 
  • Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. 
  • MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma. 
  • Microduplication 22q11.2, an emerging syndrome: clinical, cytogenetic, and molecular analysis of thirteen patients. 
  • Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates. 
  • Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair. 
  • Partial duplication of 4q12q13 leads to a mild phenotype. 
  • Phylogenetic analysis of vertebrate lactate dehydrogenase (LDH) multigene families. 
  • Phylogeny of Toll-like receptor signaling: adapting the innate response. 
  • Plant evolutionary genomics. 
  • Prolonged Adaptive Evolution of a Defensive Gene in the Solanaceae. 
  • Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers. 
  • Relaxed selection among duplicate floral regulatory genes in Lamiales. 
  • Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. 
  • Subfunctionalization: How often does it occur? How long does it take? 
  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes. 
  • T (brachyury) gene duplication confers major susceptibility to familial chordoma. 
  • The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. 
  • The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. 
  • The DNA sequence and biological annotation of human chromosome 1. 
  • The characterization of twenty sequenced human genomes. 
  • The evolving picture of microdeletion/microduplication syndromes in the age of microarray analysis: variable expressivity and genomic complexity. 
  • The genome of a cave plant, Primulina huaijiensis, provides insights into adaptation to limestone karst habitats. 
  • The genome of a songbird. 
  • The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering. 
  • Theoretical and practical advances in genome halving. 
  • Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast. 
  • Universal nomenclature for oxytocin-vasotocin ligand and receptor families. 
  • When two is better than one. 
  • Whole-genome duplication and molecular evolution in Cornus L. (Cornaceae) - Insights from transcriptome sequences. 
  • Widespread false gene gains caused by duplication errors in genome assemblies. 
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  Keywords of People

  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology