Guanine Nucleotide Exchange Factors
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Subject Areas on Research
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A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans.
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A bacterial virulence protein suppresses host innate immunity to cause plant disease.
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A cell cycle checkpoint monitors cell morphogenesis in budding yeast.
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A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy.
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A plant genetic network for preventing dysbiosis in the phyllosphere.
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A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.
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A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.
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ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.
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Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.
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Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
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Bacteria establish an aqueous living space in plants crucial for virulence.
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Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.
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Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
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Calcium channel function regulated by the SH3-GK module in beta subunits.
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Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
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Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.
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Cell wall remodeling and vesicle trafficking mediate the root clock in Arabidopsis
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Clinically focused exome sequencing identifies an homozygous mutation that confers DOCK8 deficiency.
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Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
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Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.
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Critical roles of RasGRP1 for invariant NKT cell development.
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Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach.
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De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies.
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Differential requirement of RasGRP1 for γδ T cell development and activation.
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Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
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Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
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Effector-triggered immunity blocks pathogen degradation of an immunity-associated vesicle traffic regulator in Arabidopsis.
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Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
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Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
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Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
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Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.
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Genetics of physiological dysregulation: findings from the long life family study using joint models.
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Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
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Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
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Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
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Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
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Identification of novel mediators of NF-kappaB through genome-wide survey of monocyte adherence-induced genes.
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Incorporating Functional Information in Tests of Excess De Novo Mutational Load.
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Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
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Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit.
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Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
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Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.
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Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.
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Morbidity, Mortality, and Therapeutics in Combined Immunodeficiency: Data From the USIDNET Registry.
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Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis.
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Muscle giants: molecular scaffolds in sarcomerogenesis.
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Negative feedback enhances robustness in the yeast polarity establishment circuit.
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Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
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PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.
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Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.
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Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
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Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
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Polarity establishment requires localized activation of Cdc42.
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RAP2 mediates mechanoresponses of the Hippo pathway.
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RCC1, a regulator of mitosis, is essential for DNA replication.
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Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
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RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
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Ratiometric GPCR signaling enables directional sensing in yeast.
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Regulator of G-protein signaling (RGS) proteins in cancer biology.
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RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.
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Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.
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Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.
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Selective uncoupling of G alpha 12 from Rho-mediated signaling.
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Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.
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Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
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Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction.
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Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.
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The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
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The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.
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The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
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The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.
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The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
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The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.
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The role and regulation of mTOR in T-lymphocyte function.
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Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia.
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Transcriptomics integrated with metabolomics reveals the effect of Bisphenol F (BPF) exposure on intestinal inflammation.
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Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.
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Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.
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Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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Keywords of People
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Bejsovec, Amy,
Associate Professor of Biology,
Biology
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Lew, Daniel Julio,
James B. Duke Distinguished Professor of Pharmacology and Cancer Biology,
Cell Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology