Guanine Nucleotide Exchange Factors
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Subject Areas on Research
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A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans.
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A cell cycle checkpoint monitors cell morphogenesis in budding yeast.
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A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy.
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A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.
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A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.
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Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.
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An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response.
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Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
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Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
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Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.
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CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.
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Calcium channel function regulated by the SH3-GK module in beta subunits.
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Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
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Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.
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Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
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Critical roles of RasGRP1 for invariant NKT cell development.
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Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach.
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De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies.
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Differential requirement of RasGRP1 for γδ T cell development and activation.
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Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
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Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
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Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
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Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
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Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.
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Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
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Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
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Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
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Incorporating Functional Information in Tests of Excess De Novo Mutational Load.
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Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
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Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit.
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Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
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Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.
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Muscle giants: molecular scaffolds in sarcomerogenesis.
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Negative feedback enhances robustness in the yeast polarity establishment circuit.
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Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
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PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.
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PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion.
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Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.
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Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
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Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
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Polarity establishment requires localized activation of Cdc42.
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RCC1, a regulator of mitosis, is essential for DNA replication.
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Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical-basal polarity establishment.
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Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
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Regulation of RasGRP1 function in T cell development and activation by its unique tail domain.
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Regulator of G-protein signaling (RGS) proteins in cancer biology.
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RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.
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Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.
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Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.
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Selective uncoupling of G alpha 12 from Rho-mediated signaling.
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Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
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Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.
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The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
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The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.
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The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
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The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.
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The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.
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The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
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The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.
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The role and regulation of mTOR in T-lymphocyte function.
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The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development.
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Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.
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Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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Keywords of People
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Bejsovec, Amy,
Associate Professor of Biology,
Biology
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Lew, Daniel Julio,
James B. Duke Professor of Pharmacology and Cancer Biology,
Cell Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology