Guanine Nucleotide Exchange Factors
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Subject Areas on Research
- A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans.
- A bacterial virulence protein suppresses host innate immunity to cause plant disease.
- A cell cycle checkpoint monitors cell morphogenesis in budding yeast.
- A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy.
- A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.
- A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans.
- Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.
- Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors.
- Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p.
- Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
- Bacteria establish an aqueous living space in plants crucial for virulence.
- Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
- Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.
- Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
- CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.
- Calcium channel function regulated by the SH3-GK module in beta subunits.
- Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor.
- Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.
- Cell wall remodeling and vesicle trafficking mediate the root clock in Arabidopsis .
- Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
- Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.
- Critical roles of RasGRP1 for invariant NKT cell development.
- Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach.
- De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies.
- Differential requirement of RasGRP1 for γδ T cell development and activation.
- Early de novo DNA methylation and prolonged demethylation in the muscle lineage.
- Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
- Effector-triggered immunity blocks pathogen degradation of an immunity-associated vesicle traffic regulator in Arabidopsis.
- Enhanced T cell responses due to diacylglycerol kinase zeta deficiency.
- Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades.
- Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
- Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.
- Genetics of physiological dysregulation: findings from the long life family study using joint models.
- Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
- Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
- Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
- Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf.
- Incorporating Functional Information in Tests of Excess De Novo Mutational Load.
- Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.
- Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit.
- Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
- Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.
- Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.
- Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis.
- Muscle giants: molecular scaffolds in sarcomerogenesis.
- Negative feedback enhances robustness in the yeast polarity establishment circuit.
- Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
- PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.
- Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.
- Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
- Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
- Polarity establishment requires localized activation of Cdc42.
- RAP2 mediates mechanoresponses of the Hippo pathway.
- RCC1, a regulator of mitosis, is essential for DNA replication.
- Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation.
- RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
- Ratiometric GPCR signaling enables directional sensing in yeast.
- Regulator of G-protein signaling (RGS) proteins in cancer biology.
- RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration.
- Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU.
- Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.
- Selective uncoupling of G alpha 12 from Rho-mediated signaling.
- Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing.
- Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.
- Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction.
- Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.
- Temporal Profiling of Astrocyte Precursors Reveals Parallel Roles for Asef during Development and after Injury.
- The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
- The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.
- The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
- The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis.
- The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
- The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9.
- The role and regulation of mTOR in T-lymphocyte function.
- Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia.
- Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.
- Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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Keywords of People
- Bejsovec, Amy, Associate Professor of Biology, Biology
- Lew, Daniel Julio, James B. Duke Distinguished Professor of Pharmacology and Cancer Biology, Cell Biology
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
- Zhong, Xiaoping, Professor of Pediatrics, Immunology