cdc25 Phosphatases

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  Subject Areas on Research

  • A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. 
  • Activation of MAPK/ERK signaling by Burkholderia pseudomallei cycle inhibiting factor (Cif). 
  • Cell cycle. Checking two steps. 
  • Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. 
  • Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. 
  • Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate. 
  • Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. 
  • Kinetic analysis of the catalytic domain of human cdc25B. 
  • Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. 
  • Mechanism of Cdc25B phosphatase with the small molecule substrate p-nitrophenyl phosphate from QM/MM-MFEP calculations. 
  • Nucleo-cytoplasmic interactions that control nuclear envelope breakdown and entry into mitosis in the sea urchin zygote. 
  • PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation. 
  • Phosphatases driving mitosis: pushing the gas and lifting the brakes. 
  • Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program. 
  • Requirement of the prolyl isomerase Pin1 for the replication checkpoint. 
  • Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. 
  • Short-term integration of Cdc25 dynamics controls mitotic entry during Drosophila gastrulation. 
  • The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. 
  • When the checkpoints have gone: insights into Cdc25 functional activation.